Person: KURTULMUŞ, AYŞE
10 results
Search Results
Now showing 1 - 10 of 10
Publication Metadata only Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia(2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETAim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.Publication Metadata only Eating disorders in patients with irritable bowel syndrome(2020-12-01T00:00:00Z) Kayar, Yusuf; Agin, Mehmet; Dertli, Ramazan; Kurtulmus, Ayse; Boyraz, Rabia Keyser; Onur, Nafiye Selcan; KIRPINAR, İSMET; KURTULMUŞ, AYŞE; ÖNÜR, NAFIYE SELCAN; KIRPINAR, İSMETIntroduction: Eating disorders (ED) constitute an important group of conditions that commonly occur in adolescents. Gastrointestinal complaints are frequently reported in ED patients. Few studies assessed the association of irritable bowel syndrome (IBS) with ED. The aim of the current study is to determine the prevalence of ED in a group of IBS patients and compare it with a healthy control group and assess the relationship of IBS sub-types, it-s duration and severity with ED.Publication Metadata only Role of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia(2018-05-01) SAHBAZ, Cigdem; Zibandeyeh, Noushin; Kurtulmus, AYŞE; AVAROGLU, Gamze; Kirpinar, Ismet; Sahin, Fikrettin; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETPublication Metadata only 2 Kirpinar I, Gormez A, Kurtulmus A. A case of Niemann-Pick type C disease with juvenile onset neuropsychiatric symptoms.(2016-09-20) KIRPINAR, İSMET; Görmez, Aynur; Kurtulmuş, AYŞE; KIRPINAR, İSMET; KURTULMUŞ, AYŞEPublication Metadata only Antidepressants induced tardive dystonia a case report(2015-04-19) KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM; KOÇER, EMEL; GÖRMEZ, AYNUR; KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEMPublication Metadata only Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.(2019-06-01) SAHBAZ, C; Özer, OF; KURTULMUS, AYŞE; KıRPıNAR, I; SAHIN, F; GULOKSUZ, S; ŞAHBAZ, ÇIĞDEM DILEK; ÖZER, ÖMER FARUK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETPublication Metadata only Bilişsel Bozulma Gösteren Yaşlı Hastalarda Ruhsal ve Davranışsal Belirtilerin Dağılımı(2014-11-16) KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM; KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEMPublication Metadata only A case of Niemann-Pick type C disease with juvenile onset neuropsychiatric symptoms(2016-10-01) Kirpinar, I.; GORMEZ, A.; KURTULMUS, AYŞE; KIRPINAR, İSMET; KURTULMUŞ, AYŞEPublication Metadata only Prevalence of ADHD and co-morbid conditions among university students(2017-04-01) GÖRMEZ, AYNUR; KOCER, E.; KURTULMUS, AYŞE; Kirpinar, I.; KURTULMUŞ, AYŞE; KIRPINAR, İSMETPublication Metadata only Iron metabolism and haematological changes in anorexia nervosa: an adult case report(2018-06-01) GÖRMEZ, AYNUR; Kurtulmus, AYŞE; Kirpinar, Ismet; KURTULMUŞ, AYŞE; KIRPINAR, İSMET