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SEYİTHANOĞLU, MEHMET HAKAN

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MEHMET HAKAN
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SEYİTHANOĞLU
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2010 - 201910
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End date: 2019 × Start date: 2010 × Rights: info:eu-repo/semantics/openAccess ×

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Now showing 1 - 10 of 10
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    PublicationOpen Access
    A Rare Cause of Headache in the Emergency Department: Intraventricular Epidermoid Cyst Rupture With Hydrocephalus.
    (2016-07-01) YIGIT, M; Seyithanoglu, MEHMET HAKAN; DUNDAR, TOLGA TURAN; SOGUT, O; YIGIT, E; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN
    Lateral intraventricular tumors are not frequently observed. Since these tumors grow linearly rather than exponentially, they grow gradually and thus do not cause mass effects and hydrocephalus. This study is the case report of a rare great volume left intraventricular epidermoid cyst rupture. The tumor was found to be associated with mass effect on neighboring structures and hydrocephalus.
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    PublicationOpen Access
    Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers.
    (2018-11-17) SEYITHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHIM SA; Dündar, TOLGA TURAN; KITIŞ, SERKAN; ARALAŞMAK, AYŞE; Gündağ, Papaker; SASANI, H; SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHıM SA; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; ARALAŞMAK, AYŞE; GUNDAG, MELİHA
    Background: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. Material/Methods: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). Results: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. Conclusions: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposure
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    Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP in Residue Evaluation of Treated Intracranial Aneurysms
    (2018-01-01) Dundar, TOLGA TURAN; Kits, Serkan; Ozdemir, HÜSEYİN; Seyithanoglu, MEHMET HAKAN; Uysal, Omer; Toprak, HÜSEYİN; Ozek, ERDİNÇ; Alkan, ALPAY; DÜNDAR, TOLGA TURAN; ARALAŞMAK, AYŞE; ÖZDEMİR, HÜSEYIN; SEYİTHANOĞLU, MEHMET HAKAN; UYSAL, ÖMER; TOPRAK, HÜSEYİN; KİTİŞ, SERKAN; ÖZEK, ERDİNÇ; ALKAN, ALPAY
    AIM: To compare effectiveness of contrast-enhanced magnetic resonance angiography (CE-MRA), 3D-Time-of-flight magnetic resonance angiography (3D-TOF-MRA) and subtracted computed tomography angiography from computed tomography perfusion (sub-CTA) in residue evaluation of intracranial aneurysms treated either with coiling or clipping.
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    The efficacy of gamma knife radiosurgery in patients with trigeminal neuralgia: The initial experience of the Bezmialem Vakif University
    (2019-03-01T00:00:00Z) Akdag, Halil; Comert, Didem; Akdur, Kerime; Sakarcan, Ayten; Seyithanoglu, Hakan; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ
    Background: Gamma knife stereotactic radiosurgery is, compared with surgical treatment, a less invasive treatment option for patients with trigeminal neuralgia (TN).
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    Otogenic and rhinosinusogenic intracranial complications in children.
    (2017-12-05) TÜREL Ö.; USTABAŞ KAHRAMAN F.; DÜNDAR T. T.; SEYİTHANOĞLU M. H.; ÇAKIN Z. E.; DOĞAN DEMİR A.; TÜREL, ÖZDEN; USTABAŞ KAHRAMAN, FEYZA; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; DOĞAN DEMİR, AYŞEGÜL
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    PublicationOpen Access
    Glioblastoma Stem Cells and Comparison of Isolation Methods.
    (2019-06-01) Kaynar, MY; Dundar, TOLGA TURAN; Hatiboglu, MA; Ergul, Z; Sozen, E; Seyithanoglu, MH; Tuzgen, S; Karaoz, E; DÜNDAR, TOLGA TURAN; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN
    Background: Glioblastoma (GBM) is the most aggressive and the most common primary brain tumor. Over the last few years, studies have identified many genetical and phenotypical molecular situations for developing new treatment modalities in patients with GBM. Nevertheless, main problem for the GBM is radio-chemotherapy resistance and relapse after the surgery. The identification of glioma stem cells and microenvironmental influences has created a paradigm shift in targets of therapy. Current studies have shown that glioma stem cell is responsible for aggressiveness, recurrence and resistance to therapy of GBM. GBM stem cell isolated from human GBM multiforme fresh tissue samples is important both for curative therapeutic options and personalized targeted therapy. The purpose of this study was to determine the most suitable isolation method of GBM stem cells (GSCs). Methods: Tumor tissue sample was obtained during the surgical resection of lesion in patients with the diagnosis of GBM. Tumor stem cell isolation from tissue was performed in three different ways: 1) GBM cell isolation with trypsin; 2) GBM cell isolation with brain tumor dissociation Kit (BTD Kit); and 3) GBM cell isolation with tumor dissociation enzyme (TDE). Results: We showed that GSCs were isolated from tumor specimen using flow cytometry and immunofluorescence staining. Our study showed that isolation with BTD Kit is the most suitable method to isolate GBM tissue-derived glial tumor stem cells. Conclusions: The development of alternative personalized therapies targeting brain tumor stem cell is urgently needed. It is important to understand the fundamental mechanisms of driving stem cells. If their life cycle mechanisms can be identified, we can control the growth of GBM.
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    PublicationOpen Access
    Spontaneous Resolution of Paraparesis Because of Acute Spontaneous Thoracolumbar Epidural Hematoma
    (2012-01-01) GUNDAG, MELİHA; DOGAN, K.; Kitis, SERKAN; Ozkan, N.; GUNDAG, MELİHA; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN
    Symptomatic spontaneous spinal epidural hematoma(SSEH) is an uncommon cause of cord compression that commonly is considered an indication for emergent surgical decompression. We aimed to investigate a patient with a SSEH that completely resolved clinically and radiographically, without surgical treatment. The patient presented three days after the sudden onset of back pain, numbness, and weakness. Magnetic Resonance Imaging (MRI) revealed a posterior thoracolumbar epidural hematoma extending from the level of T10 to L2 with significant cord compression. Decompression was recommended but he refused surgery and was managed conservatively. One month later weakness totally recovered and hematoma was absent on MRI.
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    Choosing the most efficacious scoring method for carpal tunnel syndrome
    (2015-01-01T00:00:00Z) Yucel, Hulya; Seyithanoglu, Hakan; YÜCEL, HÜLYA; SEYİTHANOĞLU, MEHMET HAKAN
    Objective: The aim of this study was to determine the most efficacious hand-specific questionnaire to determine functionality in patients with carpal tunnel syndrome.
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    Effect of Short-term 900 MHz low level electromagnetic radiation exposure on blood serotonin and glutamate levels
    (2015-01-01T00:00:00Z) Eris, A. H.; Kiziltan, H. S.; Meral, I; Gene, H.; Trabzon, M.; Seyithanoglu, H.; Yagci, B.; Uysal, O.; MERAL, İSMAİL; SEYİTHANOĞLU, MEHMET HAKAN
    Background: Long term exposure to low level electromagnetic radiation (LLER) by using cellular phones causes serious health problems.
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    PublicationOpen Access
    Chronic Ossified Epidural Hematoma After Ventriculoperitoneal Shunt Insertion: A Case Report
    (2010-10-01T00:00:00Z) Seyithanoglu, Hakan; Guzey, Feyza Karagoz; Emel, Erhan; Ozkan, Nezih; Aycan, Abdurrahman; SEYİTHANOĞLU, MEHMET HAKAN
    Chronic calcified/ossified epidural hematoma is an uncommon complication of ventricular shunt surgery. There are only 4 cases related to valve-regulated shunt operations in the literature. It may be seen especially in young patients with chronic hydrocephalus, probably due to craniocerebral disproportion. The precise mechanism of the calcification or ossification of the hematoma is not known, however, the dura mater seems to play a part in this process. A 17-year-old girl with triventricular hydrocephalus was treated with a ventriculoperitoneal shunt system including a medium pressure flow control valve. She was admitted with a complaint of severe headache after three years and a bifrontal calcified/ossified epidural hematoma was seen. The calcifying hematoma was removed and the patient-s headache resolved. Although the use of high or medium pressure valves, valves with an antisiphon device, adjustable pressure valves or flow control valves have been recommended to prevent this complication in previous reports, it was seen that our case had been treated with a medium pressure flow control valve.