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SEYİTHANOĞLU, MEHMET HAKAN

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MEHMET HAKAN
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SEYİTHANOĞLU
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2012 - 20193
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Author: GUNDAG, MELİHA × Has files: true ×

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    PublicationOpen Access
    Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers.
    (2018-11-17) SEYITHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHIM SA; Dündar, TOLGA TURAN; KITIŞ, SERKAN; ARALAŞMAK, AYŞE; Gündağ, Papaker; SASANI, H; SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHıM SA; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; ARALAŞMAK, AYŞE; GUNDAG, MELİHA
    Background: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. Material/Methods: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). Results: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. Conclusions: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposure
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    PublicationOpen Access
    Spontaneous Resolution of Paraparesis Because of Acute Spontaneous Thoracolumbar Epidural Hematoma
    (2012-01-01) GUNDAG, MELİHA; DOGAN, K.; Kitis, SERKAN; Ozkan, N.; GUNDAG, MELİHA; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN
    Symptomatic spontaneous spinal epidural hematoma(SSEH) is an uncommon cause of cord compression that commonly is considered an indication for emergent surgical decompression. We aimed to investigate a patient with a SSEH that completely resolved clinically and radiographically, without surgical treatment. The patient presented three days after the sudden onset of back pain, numbness, and weakness. Magnetic Resonance Imaging (MRI) revealed a posterior thoracolumbar epidural hematoma extending from the level of T10 to L2 with significant cord compression. Decompression was recommended but he refused surgery and was managed conservatively. One month later weakness totally recovered and hematoma was absent on MRI.
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    PublicationOpen Access
    Investigation of cytotoxic, genotoxic, and apoptotic effects of curcumin on glioma cells
    (2019-03-01) SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS; kitiş, serkan; GÜLER, ERAY METİN; DÜNDAR, TOLGA; GÜNDAĞ PAPAKER, MELİHA; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; DÜNDAR, TOLGA TURAN; GUNDAG, MELİHA