Person: ÇAĞMAN, ZEYNEP
16 results
Search Results
Now showing 1 - 10 of 16
Publication Metadata only A Candidate Therapeutic Target For Diabetic Nephropathy: Gas6 (Growth Arrest Spesific Protein)(2010-06-12T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Reference Interval For Plasma Gas6 Growth Arrest Specific 6(2012-07-18T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Estimation Of Reference İntervals For Plasma Growth Arrest-Specific 6(2017-04-29T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Sağlıklı yetişkinlerde plazma Gas6 seviyelerinin belirlenmesi(2010-09-25T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Alendronatın Overektomili Sıçanlarda Karaciğer Dokusu Üzerindeki Biyokimyasal Etkileri(2011-07-02T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Gas6 gene expression and tyrosine kinase Axl Sky receptors: Its relation with tumor stage and grade in patients with bladder cancer(2014-04-15T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Diabetik nefropatide yeni bir hedef molekül: Gas6(2010-09-25T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Absans Epilepside Gas6, Protein S ve TAM Reseptörlerinin Araştırılması(2015-09-02T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Metadata only Mesane Kanserli Hastalarda Gas6 Gen Ekspresyonu Ve Tirozin Kinaz Axl – Sky Reseptorleri: Tumor Evresi Ve Derecesi İle İlişkisi(2013-11-07T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEPPublication Open Access Gas6 expression and Tyrosine kinase Axl Sky receptors: Their relation with tumor stage and grade in patients with bladder cancer(2021-06-01T00:00:00Z) Akgül, Hacı Murat; Baykan, Özgür; Çağman, Zeynep; Özyürek, Mustafa; Tinay, İlker; Akbal, Cem; Uras, Fikriye; Türkeri, Levent; ÇAĞMAN, ZEYNEPObjectives: It has been shown that the dysregulation of tyrosine kinase Axl receptor and its ligand growth arrest-specific gene (Gas6) are associated with poor prognosis in various types of tumors but there is not enough study about their importance in bladder cancer (BC). We evaluated the relation of Gas6 gene expression and tyrosine- kinase Axl and Sky (Tyro 3) receptors with tumor stage and grade in patients with BC. Material and methods: The study group consists of 55 patients whose transurethral resection of bladder (TUR-B) has been performed due to BC and the control group consists of 12 patients with normal bladder mucosa. In tissues mRNAs of Gas6, Axl, and Sky receptors were examined by quantitative (Real-Time) PCR (qPCR). Protein expression was measured by immunohistochemistry. Plasma Gas6 protein levels were compared with control group by ELISA method. Results: Patients with BC were grouped as Ta low (n=17), Ta high (n=5), T1 low (n=9), T1 high (n=8) and T2 (n=16) according to their TUR-B pathologies. The qPCR analysis showed that the expression of Gas6 gene and Axl receptor is higher in the tumor-positive group and the immune-histochemical showed that the bladder samples of the tumor-positive group stained significantly positive. When the patients are grouped according to the TUR-B pathologies, a statistical significant difference was observed among groups in the qPCR analysis ratios of Gas6 gene and Axl receptor by (p < 0.05) but no significance was found for Sky receptor (p > 0.05). When Gas6 protein levels in plasma samples were compared by ELISA method, a statistical significance was determined among groups (p = 0.001). Conclusions: Our findings indicate that mRNAs of Gas6 and Axl receptor are closely related to tumor stage and grade in patients with BC. Further studies are needed for understanding the role of Gas6 and its receptors on the neoplastic transformation in terms of novel biomarkers and potential therapeutic targets.