Person: SÖNMEZ, ERTAN
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Publication Metadata only Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis(2016-01-01) DUR, Ali; KOCAMAN, Orhan; Kocyigit, ABDÜRRAHİM; Turkdogan, Kenan Ahmet; Sonmez, ERTAN; KESKIN, Siddika; YIGIT, Mehmet; Gulen, BEDİA; KILIC, Elif; Uysal, Omer; KOÇYİĞİT, ABDÜRRAHİM; SÖNMEZ, ERTAN; GÜLEN, BEDİA; UYSAL, ÖMERBackground/Aims: Acute pancreatitis (AP) is a life-threatening disease with a rising incidence. The aim of this study was to investigate the association between oxidative status, lymphocyte deoxyribonucleic acid (DNA) damage, and acute pancreatitis.Publication Metadata only Efficacy of Prothrombin Complex Concentrates for Oral Anticoagulant Therapy-related Major Hemorrhage(2015-03-01) ÇAVUŞ, Umut Yucel; Yildirim, SİNAN; YURTSEVEN, Aynur; Sonmez, ERTAN; YILDIRIM, SİNAN; SÖNMEZ, ERTANIn patients admitted to accident and emergency departments for anticoagulant use-related major hemorrhage and requiring urgent surgery or life-saving invasive intervention, the international normalized ration (INR) value should be rapidly corrected and bleeding should be controlled. With prothrombin complex concentrate (PCC), when used at optimal dose levels, target INR values are achieved within 15 min. In this study, we aimed to discuss the efficacy of the used four-factor PCC in 10 patients who were admitted to the accident and emergency department because of oral anticoagulant use-related major bleeding. Of all the patients to whom PCC treatment was administered, targeted INR levels could not be attained in 2 patients (20%). For our cases with gastrointestinal bleeding, the average baseline INR value was 7.3, while the average INR value after PCC administration was 1.9. For our subdural hematoma cases, the median baseline INR value was 2.5, while the median INR value after PCC administration was 1.3. We believe that PCCs used in eligible patient groups, as in this case series, may provide the desired results at lower doses and that they may be safer with regard to complications.Publication Metadata only The predictive value of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) in terms of the duration of peripheral ischemia and exposure to reperfusion(2017-01-01) SÖĞÜT, Ozgur; Sonmez, ERTAN; YIGIT, Mehmet; Turkdogan, Kenan Ahmet; KUCUKDAGLI, Okkes Taha; YİĞİT, Eda; Ozer, Omer Faruk; CİVELEK, Cemil; SÖNMEZ, ERTAN; ÖZER, ÖMER FARUKBiomarkers play important roles in the diagnosis and follow-up of ischemic diseases. This study investigated the predictive value of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) in rats with peripheral ischemia that were subjected to reperfusion. Forty rats were divided into five equal groups as follows (eight rats per group): a control group (to determine the basal levels of the markers), three ischemia groups (groups 1-3), and a reperfusion group (group 4). There were no significant differences in SCUBE1 levels between the control and ischemia groups. However, the SCUBE1 level was markedly higher in the reperfusion group than in the control and ischemia groups (p<0.05). The results indicate that SCUBE1 levels are not biomarkers of the induction of ischemia. However, they are potentially markers of reperfusion in rats with acute peripheral occlusions.Publication Metadata only The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome(2015-01-01) Sonmez, ERTAN; TURKDOGAN, Kenan Ahmet; KARABACAK, Mustafa; CİVELEK, Cemil; YILMAZ, Cahit; Ozer, Omer Faruk; ÇAVUŞ, Umut Yucel; SÖNMEZ, ERTAN; ÖZER, ÖMER FARUKObjective: Chest pain and/or electrocardiogram changes in non-ST elevation or suspicious chest pain and cardiac marker elevations are defined as non-ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the a granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain.Publication Metadata only The Diagnostic Value of SCUBE1 in Unstable Angina Pectoris Patients(2016-12-01) OZKAN, Abuzer; Sonmez, ERTAN; OZDEMIR, Serdar; Ozer, Omer Faruk; MUHARREM, Nasifov; Gulen, BEDİA; KESKIN, Muhammed; SÖNMEZ, ERTAN; ÖZER, ÖMER FARUK; GÜLEN, BEDİAAim: Signal peptide complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor-like domain-containing protein 1 (SCUBE1) has been used in research as a biomarker in acute coronary syndrome (ACS). The aim of this study is to determine if SCUBE1 and routine laboratory parameters are effective in distinguishing the patients presenting with clinical symptoms of unstable angina pectoris (USAP) from the patients who have non-ST-segment elevated myocardial infarction (NSTEMI) and non-cardiac chest pain patients (NCCP).Publication Open Access Work-related injuries sustained by emergency medical technicians and paramedics in Turkey(2016-03-01) Gulen, BEDİA; Serinken, Mustafa; HATIPOGLU, Celile; OZASIR, Derya; Sonmez, ERTAN; KAYA, Gokhan; AKPINAR, Guleser; GÜLEN, BEDİA; SÖNMEZ, ERTANBACKGROUND: Evaluated in the present study were locations, descriptions, and results of work-related injuries (WRIs) sustained by emergency medical technicians (EMTs) and paramedics in Turkey’s most crowded city, İstanbul. METHODS: After the present study had been accepted by the urban health authority, a questionnaire was emailed to the healthcare personnel of İstanbul’s 195 ambulance stations. RESULTS: Included in the present study were the responses of 901 members of staff (660 EMTs and 241 paramedics), with a mean age of 29.5±6.1 (min: 18; max: 61). The majority of participants (94.9%) had encountered verbal abuse from the public, and 39.8% had encountered physical violence from patients’ relatives. Levels of satisfaction with work in emergency medical services (EMS) was also evaluated, and 510 participants (57.6%) were unhappy. Regarding gender, female employees were more likely to be verbally attacked (p=0.01), while males were more likely to be physically attacked (p=0.001). It was reported that motor vehicle accidents (MVAs) were the most common cause of WRIs (81.4%), followed by needle-stick injuries (52.2%), ocular exposure to blood and other fluids (30.9%), and sharp injuries (22.5%). Only 10.5% (n=95) of WRIs were reported to authorities; 488 (54.2%) of participants just attended to the practice to prevent possible WRIs. CONCLUSION: For paramedics and EMTs, risk of WRI is obviously high. Strategies to decrease and prevent verbal and physical violence should be developed. Keywords: Accident; ambulance;Publication Metadata only The efficacy of absorbable polysaccharide haemostats in wound healing(2015-01-01) Sonmez, ERTAN; TURKDOGAN, Kenan A.; CIVELEK, Cemil; DUR, Ali; Gulen, BEDİA; KARAYEL, Eda; Gucin, ZÜHAL; SOGUT, Ozgur; SÖNMEZ, ERTAN; GÜLEN, BEDİA; GÜCİN, ZÜHALWound healing represents an ancient problem for humans, and various materials and methods have been tried for wound dressing. A dressing should protect against infection and shorten healing; moreover, it should not cause tissue damage and should be nonallergenic, cost effective and easy to apply. These are characteristics that may be found in herbal extracts. An absorbable polysaccharide haemostat (APH) is a plant-based haemostatic agent. We aimed to evaluate the effect of APH on wound healing. A total of 24 Wistar rats were divided into three groups, each consisting of eight rats. We generated triangular tissue defects on the dorsal regions of the rats. The wound size of each rat was drawn on acetate paper on the 3rd, 7th and 14th days and dressed with APH, saline and wheat meal. Wound healing rates were calculated using planimetric software. Scar tissue excision was performed on the 14th day and histopathological examination was carried out. The mean wound contraction rate was statistically higher in the APH group than in the wheat meal and saline groups on the 14th day (P0.05). However, the intensities of fibroblasts (P<0.01), vascular proliferation (P=0.01) and inflammatory score (P=0.02) were significantly different in the saline and APH groups. APH has favourable effect on wound healing. In addition to its blood-stopping effect, APH may be useful for tissue defects, which arise after trauma or surgical procedures. (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.Publication Open Access Interhemispheric Acute Subdural Hematoma: A Distinct Entity of Subdural Hematoma.(2016-02-01) SOGUT, OZGUR; YIGIT, MEHMET; TURKDOGAN, KENAN AHMET; YIGIT, EDa; Gulen, BEDİA; Sonmez, ERTAN; KAPLAN, ONUR; Toprak, HÜSEYİN; GÜLEN, BEDİA; SÖNMEZ, ERTAN; TOPRAK, HÜSEYİNPublication Metadata only A Spontaneous Thoracic Spinal Epidural Hematoma Causing Hemiplegia and Back Pain(2016-12-01) Gulen, BEDİA; Dundar, TOLGA TURAN; Sonmez, ERTAN; AKPINAR, Guleser; GÜLEN, BEDİA; DÜNDAR, TOLGA TURAN; SÖNMEZ, ERTANSpontaneous spinal epidural hematoma (SEH) is an uncommon and emergency condition leading to spinal cord compression. Early diagnosis can be achieved by magnetic resonance imaging (MRI) or computed tomography, but preferably MRI. Surgical decompression is urgent and can relieve neurologic deficits. A 27-year-old man presented to the emergency department with back pain, which began approximately 10 days before. While waiting for the results of biological markers for differential diagnosis, right hemiplegia became evident. Epidural hematoma was revealed with thoracic and lumbar MRI at level T1-T2. Hematoma evacuation and decompression laminectomy was immediately performed.Publication Open Access The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model(2014-03-01) Sonmez, ERTAN; ÇAVUŞ, Umut Yucel; CİVELEK, Cemil; DUR, Ali; KARAYEL, Eda; Gulen, BEDİA; Uysal, Omer; İPEK, Gokturk; SÖNMEZ, ERTAN; GÜLEN, BEDİA; UYSAL, ÖMERBackground: Bleeding is a major problem in warfarin pretreated patients who need emergency surgical procedures. APH is a hemostatic agent with ultra-hydrophilic and particulate properties. This study aimed to evaluate the in vivo hemostatic effect of APH in rats pretreated with warfarin. Methods: Forty-eight Wistar rats were divided into two main groups: one group was pretreated with warfarin and the other group was not. These two groups were further divided into three subgroups according to the administration of APH, wheat meal, or saline, for a total of six subgroups. Standard full thickness tissue defects were performed on the backs of the rats. Saline, wheat meal, or APH were administered to the bleeding defect site in both main groups. Hemostasis time and amount of bleeding were calculated. Results: The bleeding time in rats administered APH was significantly shorter than those administered wheat meal and saline. Consequently, the amount of bleeding was significantly less in the APH groups than in the control groups. Conclusion: APH has an effective hemostatic property in rats pretreated or non-pretreated with anticoagulants. Hemostatic agents can be useful for incidences of external bleedings, which are increasing because of anticoagulation.