Person: TOSUNER, ZEYNEP
9 results
Search Results
Now showing 1 - 9 of 9
Publication Open Access A Six Sigma Trial For Reduction of Error Rates in Pathology Laboratory(2016-09-01) TURNA, Seval; Tosuner, ZEYNEP; Gucin, ZÜHAL; Kiran, TUĞÇE; Buyukpinarbasili, NUR; TASKIRAN, Olcay; Arici, DİLEK SEMA; TOSUNER, ZEYNEP; GÜCİN, ZÜHAL; KIRAN, TUĞÇE; BÜYÜKPINARBAŞILI, NUR; TURNA, SEVAL; ARICI, DILEK SEMAObjective: The aim of this study is to determine differences of levels of empathy among undergraduates in each year of their four-year programs of physiotherapy. Methods: During the 2014-2015 academic school year, 381 physiotherapy students were enlisted from two universities in Istanbul, one a foundation and the other a government university. The Turkish version of the Jefferson Scale of Physician Empathy was administered. Students were asked to indicate interest in particular physiotherapy specialties as well as their region of origin in Turkey. The Kruskal-Wallis analysis was used to determine differences among the four study years, and also to measure relationships between specialty interest, home-region, and empathy scores of the students. Empathy scores were also compared according to gender. Results: The difference of empathy scores between the students of the two universities was borderline significant (p=0.057). Empathy scores in both universities increased to a significant degree after school entrance and decreased in the final year. Levels of empathy did not change according to gender, specialty interest, or home-region (p=0.722, 0.524, and 0.309, respectively). Conclusions: This study points to the need for physiotherapy curricula that would enhance empathy and give students practice in exhibiting this valuable attribute. Additional studies are needed that would include larger study populations and track the same students year by year as to how and why their empathy levels change during their training.Publication Open Access Familial amyloid polyneuropathy due to p.ALA140 ser mutation(2018-01-01) GÜRSOY, Azize; YEŞİL, GÖZDE; ERGÜN, SELMA; Tosuner, ZEYNEP; GÜRSOY, AZIZE ESRA; YEŞİL, GÖZDE; ERGÜN, SELMA; TOSUNER, ZEYNEPPublication Open Access The Role of EGFR, Hepatocyte Growth Factor Receptor (c-Met), c-ErbB2 (HER2-neu) and Clinicopathological Parameters in the Pathogenesis and Prognosis of Chordoma(2017-05-01T00:00:00Z) TOSUNER, ZEYNEP; BOZKURT, SÜHEYLA; KILIÇ, TÜRKER; Yilmaz, Baran; TOSUNER, ZEYNEPObjective: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to analyse the histopathological features of chordomas and the immunoexpression profiles of the three receptor tyrosine kinases of EGFR, c-Met and c-Erb-B2 in chordomas. We have correlated these results with recurrence and overall survival status of the patients.Publication Open Access Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion(2017-01-01T00:00:00Z) Tosuner, Zeynep; Turkmen, Ilknur; Arici, Sema; Sonmez, Cavide; Turna, Seval; Onaran, Oyku; TOSUNER, ZEYNEP; TURNA, SEVALAims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears. Settings and Design: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions. ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) has been considered to have tight association with high grade intraepithelial lesions. Materials and Methods: A total number of 54 SurePath cervical cytology specimens of patients previously interpreted as atypical squamous cells-undetermined significance (ASC-US), atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H), low grade squamous intraepithelial lesion (LSIL), and high grade squamous intraepithelial lesion (HSIL) were included in our study. Results and Conclusions: ProEx C was positive in 14 of HSILs (100%), 3 of 19 LSILs (16%), 2 of 4 ASC-Hs, and none of ASC-USs (0%). The ProEx C test showed very intense nuclear staining in all cytologically abnormal cells. Further studies are indicated to evaluate the diagnostic role of ProEx C.Publication Open Access Cotyledonoid Dissecting Leiomyoma with Symplastic Features: Case Report.(2017-08-01) SONMEZ, FATMA CAVİDE; TOSUNER, ZEYNEP; KARASU, AFG; Arıcı, DİLEK SEMA; DANSUK, RAMAZAN; SÖNMEZ, FATMA CAVİDE; TOSUNER, ZEYNEP; ARICI, DILEK SEMA; DANSUK, RAMAZANForeign bodies are rare and challenging issues leading to symptoms according to the location. Laparoscopy is a popular and minimally invasive method used for removal of foreign bodies in the abdominal cavity or retroperitoneum. We herein report a case with retroperitoneal foreign body that was removed through retroperitoneal single- port laparoscopy using nephroscope. To our knowledge this is the first case of removal of a retroperitoneal foreign body through single- port laparoscopy using nephroscope.Publication Open Access A Primary Adenosquamous Carcinoma of the Stomach: Report of Two Cases(2017-07-01) Gecer, MELİN; Unver, NURCAN; HASBAHCECI, Mustafa; Gucin, ZÜHAL; Tosuner, ZEYNEP; Akcakaya, ADEM; Arici, Sema; GEÇER, MELİN; ÜNVER, NURCAN; GÜCİN, ZÜHAL; TOSUNER, ZEYNEP; ÇOBAN, EZGİ; AKÇAKAYA, ADEM; ARICI, DILEK SEMAPrimary gastric adenosquamous carcinomas are extremely rare tumors. A gradual transition between the malignant glandular and squamous components of the tumor is seen on performing a histopathological evaluation. These tumors are known to have poorer clinical outcomes than conventional adenocarcinomas. We aimed to present two cases of primary adenosquamous carcinomas that were diagnosed at the later stage in our institute.Publication Open Access The relationship of erythropoietin receptor expression and prognosis in glioblastoma multiforme patients.(2018-04-01) ÇEVIK, Serdar; Kitis, SERKAN; EVRAN, Şevket; AKKAYA, Enes; TOSUNER, ZEYNEP; HANIMOGLU, Hakan; KİTİŞ, SERKAN; TOSUNER, ZEYNEPBackground: Glioblastoma multiforme (GBM) is the most common primary brain tumor characterized with poor prognosis and short survival. In addition to the standard treatment protocols, targeted molecular treatment options are under trial. In the recent trials, erythropoietin and erythropoietin receptor were found to be linked with the progression of GBM cells. Aim: In this study, we compared the expression of EPOR with survival in GBM patients with mortality. Materials and Methods: Twenty‑six patients operated for GBM in 2012–2014 were enrolled in this study. Tumor tissues were stained with EPOR, epidermal growth factor receptor, vascular endothelial growth factor, and assigned as (1+), (2+), and (3+) according to their immunohistochemical staining levels. The average postoperative follow‑up time was 9.3 months. Kaplan–Meier’s survival test and Spearman’s correlation test were used in statistical analysis. Results: EPOR 1(+) stained group showed a median survival of 8 months (95% confidence interval [CI]: 0.954–15.046). EPOR 2(+) stained group showed a median survival of 6 months (95% CI: 2.901–9.090) EPOR 3(+) stained group showed a median survival of 2 months (95% CI: 0.400–3.600). (Kaplan–Meier P = 0.002). Conclusion: These results portrayed that EPOR staining levels were inversely proportional with average survival time. In the future, specific inhibitors of this molecule could be used to form a novel treatment option for GBM.Publication Open Access Carcinoid tumor arising in a mature cystic teratoma: A case report(2015-05-01) Tosuner, ZEYNEP; Sonmez, FATMA CAVİDE; Arici, DİLEK SEMA; Dansuk, RAMAZAN; TOSUNER, ZEYNEP; SÖNMEZ, FATMA CAVİDE; ARICI, DILEK SEMA; DANSUK, RAMAZANMature cystic teratomas are common benign tumors of the ovary. The most common form of malig‑ nant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoac‑ tive substances produced by the tumor. A 75‑year‑old woman suffering from groin pain was admitted to the Faculty of Medi‑ cine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7‑cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow‑up examinationsPublication Open Access Hamartoma of the breast in two patients: A case report(2013-08-01T00:00:00Z) Sonmez, FATMA CAVİDE; Gucin, ZÜHAL; Yildiz, PELİN; Tosuner, ZEYNEP; SÖNMEZ, FATMA CAVİDE; GÜCİN, ZÜHAL; YILDIZ, PELİN; TOSUNER, ZEYNEPBreast hamartomas are rare, benign, tumor-like nodules composed of glandular, adipose and fibrous tissue. The hamartoma was first described in 1971 as a lipofibroadenoma, fibroadenolipoma or adenolipoma, based on the predominant component of the breast tissue. Clinical findings resemble fibroadenoma and if there is a palpable mass, the patients may receive an immediate diagnosis. Ductal hyperplasia, apocrine metaplasia, calcification and adenosis may occur within the hamartoma, with rarer instances of lobular or ductal intraepithelial neoplasms. Although hamartoma is usually benign, a malignant transformation is possible. An excision and histological examination is necessary for the differential diagnosis and also for any epithelial lesions of the hamartoma. Simple excision is enough for treatment if there is no coincidental epithelial malignant lesion. The patients in the present study were treated by simple excision as there were no proliferative changes in the lesions. No recurrence or other problems were detected in the 18-month follow-up. The current study presents two cases of breast hamartoma that were diagnosed as an adenolipoma and a fibroadenolipoma, and then describes the macroscopic and microscopic observations of these lesions.