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KAYA, MEHMET ONUR

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Author: Bahali, ANIL GÜLSEL ×

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    PublicationOpen Access
    Evaluation of mean platelet volume in localized scleroderma
    (2017-09-01) Bahali, ANIL GÜLSEL; Su, Ozlem; Emiroglu, NAZAN; Cengiz, FATMA PELİN; Kaya, MEHMET ONUR; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; KAYA, MEHMET ONUR; ONSUN, NAHIDE
    Abstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. Objectives: To evaluate whether there was any relation between localized scleroderma and platelet parameters. Methods: Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. Results: The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01). Study Limitations: The limited number of patients and the retrospective nature of the study were our limitations. Conclusions: This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies. Keywords: Blood platelets; Scleroderma, localized; Transforming growth factor beta
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    PublicationOpen Access
    Evaluation of Mean Platelet Volume in Patients with Pigmented Purpuric Dermatosis
    (2017-01-01) Su, Ozlem; Bahali, ANIL GÜLSEL; OZKAYA, Dilek Biyik; Cengiz, FATMA PELİN; Emiroglu, NAZAN; Kaya, MEHMET ONUR; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; BIYIK ÖZKAYA, DİLEK; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; KAYA, MEHMET ONUR; ONSUN, NAHIDE
    Objective: Pigmented purpuric dermatosis (PPD) is a chronic skin disease characterized by petechial and pigmentary macules. The etiology of the disease remains unknown. Mean platelet volume (MPV) is a marker of platelet (PLT) function and activation. PLTs play important roles in inflammation and innate and adaptive immunity in addition to their roles in hemostasis and thrombosis. In this study, we investigated the possible association between MPV and PPD.