Person: AYDOĞDU, AHMET
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Publication Metadata only Neurogenic inflammation in periimplant and periodontal disease: A case-control split-mouth study(2019-08-01T00:00:00Z) Sert, Sertac; Sakallioglu, Umur; LÜTFİOĞLU, MÜGE; AYDOĞDU, AHMET; Acarel, Eser; Gunaydin, Murat; AYDOĞDU, AHMETObjective Although the regulatory effects of substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) on periodontal inflammatory responses have been described, the effects of these neuropeptides on healthy and diseased periimplant tissues are not clearly defined. Materials and methods Thirty-nine implants loaded at least for 12 months with their symmetrically matching teeth were evaluated and compared by a split-mouth study design. Six study groups were created in this regard as follows: group 1 (healthy periodontal tissues), group 2 (healthy periimplant tissues), group 3 (gingivitis), group 4 (periimplant mucositis), group 5 (periodontitis) and group 6 (periimplantitis). Clinical examinations included Silness-Loe plaque index, Loe-Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level measurements. Gingival crevicular fluid and periimplant sulcular fluid samples were collected, and the concentrations of neuropeptides were determined by enzyme-linked immunosorbent assay. Their levels and correlations were investigated together with the clinical parameters. Results Neuropeptide levels were different in the teeth and implant groups according to the periodontal status (p 0.05). Conclusion Our study demonstrated the presence of local neuropeptides in healthy and diseased periimplant tissues. The neurogenic inflammatory responses were also found to be similar in both periimplant and periodontal tissues.Publication Metadata only Effect of Photobiomodulation on Transforming Growth Factor-beta(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study(2016-06-01T00:00:00Z) Keskiner, Ilker; Lutfioglu, Muge; Aydogdu, AHMET; Saygun, N. Isil; SERDAR, Muhittin Abdulkadir; AYDOĞDU, AHMETObjective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-beta(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. Aneodymium-doped yttrium aluminumgarnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-beta(1), PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-beta(1), PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-beta(1), PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-beta(1) levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-beta(1), PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators.Publication Metadata only Gingival crevicular fluid interleukin-8 and lipoxin A(4) levels of smokers and nonsmokers with different periodontal status: a cross-sectional study(2016-08-01T00:00:00Z) Lutfioglu, M.; Aydogdu, AHMET; Sakallioglu, E. E.; Alacam, H.; Pamuk, F.; AYDOĞDU, AHMETBackground and ObjectiveSmoking is an important risk factor for periodontal disease and effects the pathogenesis of the disease. This study evaluated the impact of smoking on gingival crevicular fluid interleukin-8 (IL-8) and lipoxin A(4) (LxA(4)) levels in patients with and without periodontal disease.Publication Metadata only The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment on gingival crevicular fluid levels of transforming growth factor-beta 1, tissue plasminogen activator and plasminogen activator inhibitor 1 in smoking and non-smoking chronic periodontitis patients: A split-mouth, randomized control study(2017-10-01T00:00:00Z) Pamuk, F.; Lutfioglu, M.; Aydogdu, AHMET; Koyuncuoglu, C. Z.; ÇİFCİBAŞI, Emine; Badur, O. S.; AYDOĞDU, AHMETBackground and ObjectiveThis study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to scaling and root planing (SRP) on smoking and non-smoking patients with chronic periodontitis.Publication Open Access Radiological evaluation of maxillary artery and descending palatine artery in the pterygopalatine fossa by 3D rotational angiography(2022-03-01T00:00:00Z) ÖZ, İbrahim İlker; AYDOĞDU, AHMET; YILMAZ, TEMEL FATİH; ÖZ, İBRAHİM İLKER; AYDOĞDU, AHMET; YILMAZ, TEMEL FATİHPurpose The aim of this study is to evaluate the branching patterns and topographical features of the third part of the maxillary artery (t-MA) and descending palatine artery (DPA) by 3-Dimensional Rotational Angiography (3DRA) images and to define the radiological classification of their variations, based upon the previous cadaveric studies and a review of the literature. Method This study was conducted from May 2020 through June 2021. All consecutive adult patients who were examined with 3D-RA were enrolled in the study. The morphological evaluations and measurements of t-MA, DPA and their branches were made on maximum intensity projection images with 10-20 mm slice thickness. Results Eighty-five hemifaces, including 58 females and 45 right sides, were evaluated. The diameter of the t-MA was measured as 1.73 +/- 0.30 mm. The most common pattern of the t-MA according to its course was loop type (63/85, 74.1%) and according to branching pattern was Type Ib (29/85, 34.1%). The mean diameter of DPA was 1.19 +/- 0.20 mm. The DPA presented as a single trunk in 11/85 cases. Type II, which was defined as one lesser palatine artery originating from distal-DPA, was the most common morphological variation (51.8%). Conclusions 3DRA imaging provides valuable information for vascular anatomical studies. The most common morphological variation related to t-MA, DPA is the distal branching pattern.Publication Metadata only Obesity and oxidative stress in patients with different periodontal status: a case-control study(2017-02-01T00:00:00Z) Atabay, V. E.; Lutfioglu, M.; Avci, B.; Sakallioglu, E. E.; Aydogdu, AHMET; AYDOĞDU, AHMETBackground and ObjectiveObesity has become an important global health concern as obesity-associated adiposity is supposedly related to systemic immunologic and inflammatory alterations. The aim of this study was to evaluate the effects of obesity on periodontally healthy and diseased tissue according to the changes in malondialdehyde (MDA), protein carbonyl (PC) and total antioxidant capacity (TAOC) levels in gingival crevicular fluid as biomarkers of oxidative stress (OS).Publication Metadata only Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia(2017-01-01T00:00:00Z) LÜTFİOĞLU, MÜGE; AYDOĞDU, AHMET; Atabay, Vadim Ekrem; SAKALLIOĞLU, ELİF ESER; AVCI, BAHATTİN; AYDOĞDU, AHMETThis study aimed to assess the impact of hyperlipidemia on healthy and diseased periodontal tissue by evaluating oxidative stress biomarkers in gingival crevicular fluid (GCF). Clinical periodontal parameters and blood serum lipid, GCF malondialdehyde (MDA), protein carbonyl (PC), and total antioxidant capacity (TAOC) levels were evaluated in six age and sex-matched groups (n = 15 each) of normolipidemic and hyperlipidemic individuals as follows: normolipidemic + periodontally healthy (H), normolipidemic + gingivitis (G), normolipidemic + chronic periodontitis (CP), hyperlipidemic + periodontally healthy (HH), hyperlipidemic + gingivitis (HG), and hyperlipidemic + CP (HCP). GCF MDA, and PC levels varied among groups, with patients with periodontitis having the highest MDA and PC levels [CP > G > H (p HG > HH (p < 0.01)] and the lowest TAOC levels [CP < G < H (p < 0.01) and HCP < HG < HH (p < 0.01)]. Furthermore, paired comparisons showed MDA and PC levels to be higher and TAOC levels to be lower in HCP compared with NCP (p < 0.01). In patients with hyperlipidemia, GCF, MDA, and PC levels positively correlated with clinical assessments and serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) levels and negatively correlated with serum high-density lipoprotein cholesterol (HDL) levels, whereas GCF TAOC levels negatively correlated with clinical assessments and serum TG, TC, and LDL levels, but positively correlated with serum HDL levels (p < 0.01). In normolipidemic patients, GCF, MDA, and PC levels positively correlated with clinical assessments and serum TG levels and negatively correlated with serum HDL levels, whereas GCF TAOC levels negatively correlated with clinical assessments and serum TG levels and positively correlated with serum HDL levels (p < 0.01). In conclusion, abnormal serum lipid subfractions could be considered a risk factor for enhancing oxidative stress in GCF in the presence of periodontal disease.Publication Metadata only CORRELATION BETWEEN PRIMERY STABILITY, PLACEMENT TORGUE AND HOUNSFIELD VALUES OF DENTAL IMPLANTS(2018-11-10) ÜNVER, TUĞBA; GAHRAMANOV, VALEH; AYDOĞDU, AHMET; TOPTAŞ, METE; GAHRAMANOV, VALEH; AYDOĞDU, AHMET; TOPTAŞ, METE; ÜNVER, TUĞBAPublication Metadata only Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin, and Receptor Activator of Nuclear Factor-kappa B Ligand in Periodontitis(2015-12-01T00:00:00Z) Aydogdu, Ahmet; Balli, UMUT; Dede, Figen Ongoz; Turer, Cigdem Coskun; Guven, Berrak; BALLI, UMUT; AYDOĞDU, AHMETBackground: To investigate changes in the levels and relative ratios of sclerostin, osteoprotegerin (OPG), and receptor activator of nuclear factor-kappa B ligand (RANKL) in the gingival crevicular fluid (GCF) of patients with periodontitis after non-surgical periodontal treatment.Publication Metadata only Quantitative changes in palatal donor site thickness after free gingival graft harvesting: a pilot study(2016-11-01T00:00:00Z) Aydogdu, Ahmet; Keskiner, Ilker; Balli, UMUT; Kaleli, Ayca E.; AYDOĞDU, AHMET; BALLI, UMUTAim: The aim of this study was to investigate how donor sites thickness quantitatively change over time and at different points of donor site in spontaneous palatal wound healing after free gingival graft (FGG) harvesting.