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DİNÇ, HARİKA ÖYKÜ

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HARİKA ÖYKÜ
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2015 - 201972020 - 20226
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Author: Kocazeybek, Bekir ×

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    Waning of SARS-CoV-2 Vaccine-Induced Immune Response over 6 Months in Peritoneal Dialysis Patients and the Role of a Booster Dose in Maintaining Seropositivity
    (2022-05-01T00:00:00Z) Murt, Ahmet; Dinc, HARİKA ÖYKÜ; Altiparmak, Mehmet Riza; Yalin, Serkan F.; Yadigar, Serap; Parmaksiz, Ergun; Kocazeybek, Bekir; Pekpak, Meltem; Ataman, Muveddet Rezzan; DİNÇ, HARİKA ÖYKÜ
    Introduction: Although lower than general population, newly developed SARS-CoV-2 vaccines generate immune responses in end-stage kidney disease patients. However, the persistence of immune responses in the long term is not known yet. This study aimed to evaluate humoral immune responses in peritoneal dialysis (PD) patients over 6 months and to analyze the effects of the booster dose. Methods: Humoral immune responses of PD patients were measured after initial SARS-CoV-2 vaccinations and after 6 months following initial vaccinations. Immune responses were compared between patients who received and did not receive booster doses. PD patients were compared with 41 hemodialysis (HD) patients and 61 healthy controls. Humoral immune responses were measured by a commercial test that detects antibodies toward the receptor-binding domain of the spike protein of SARS-CoV-2. Results: Twenty PD patients were evaluated over 6 months. The initial seropositivity rate was 90.9% with inactivated vaccine and 100% with mRNA vaccine. Seropositivity decreased to 44.4% after 6 months, and a booster dose helped in maintaining the 100% of seropositivity (p = 0.005). Magnitude of humoral response at the 6th month was also higher in patients who received the third dose (1,132.8 +/- 769.6 AU/mL vs. 400.0 +/- 294.6 AU/mL; p = 0.015). Among patients who did not receive the third dose, those who got mRNA vaccine could maintain higher seropositivity than others who got inactivated vaccine (75% vs. 40% for PD, 81.8% vs. 50% for HD). Seropositivity and antibody levels were similar for PD and HD patients after 6 months (p = 0.24 and 0.56) but lower than healthy controls (p = 0.0013). Conclusion: SARS-CoV-2 vaccine-induced antibody levels and seropositivity of PD patients significantly fall after 6 months. A booster dose after around 3 months following initial immunization might help in maintaining seropositivity.
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    The prevalence of periodontal pathogenic bacteria in atherosclerotic cardiovascular disease
    (2020-01-01T00:00:00Z) Gode, Safa; Sarp, Tevhide Z.; Saribas, Suat; Ergin, Sevgi; Kasnak, Gökhan; Dinc, HARİKA ÖYKÜ; Caliskan, Reyhan; Akkus, Seher; Tokman, Hrisi B.; Kocak, Banu T.; Demirci, Mehmet; Gareayaghi, Nesrin; Kirmusaoglu, Sahra; Tokman, Halit; Kocazeybek, Bekir; DİNÇ, HARİKA ÖYKÜ
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    The role of adenovirus 36 as a risk factor in obesity: The first clinical study made in the fatty tissues of adults in Turkey
    (2015-03-01T00:00:00Z) Ergin, Sevgi; Altan, Eda; Pilanci, Ozgur; Sirekbasan, Serhat; Cortuk, Oguz; Cizmecigil, Utku; Ersin, Idris; Elbey, Huseyin; Dinc, HARİKA ÖYKÜ; Habip, Zafer; Turan, Nuri; Arinci, Atilla; Richt, Juergen A.; Goossens, Valere J.; Karakullukcu, Asiye; Kocak, Banu Tufan; Saribas, Suat; Koksal, Selcuk; Yilmaz, Huseyin; Kocazeybek, Bekir; DİNÇ, HARİKA ÖYKÜ
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    Evaluating the effectiveness of anti-tuberculosis treatment by detecting Mycobacterium tuberculosis 85B messenger RNA expression in sputum
    (2020-01-01T00:00:00Z) Atahan, Ersan; Saribas, Suat; Demirci, Mehmet; Babalık, Aylin; Akkus, Seher; Balıkcı, Ahmet; Satana, Dilek; Ziver, Tevhide; Dinc, HARİKA ÖYKÜ; Keskin, Melike; Ozbey, Dogukan; Kocak, Banu Tufan; Gareayaghi, Nesrin; Kirmusaoglu, Sahra; Tokman, Hrisi Bahar; Kocazeybek, Bekir; DİNÇ, HARİKA ÖYKÜ
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    Helicobacter pylori-miRNA interaction in gastric cancer tissues: First prospective study from Turkey
    (2019-01-01T00:00:00Z) Demiryas, Suleyman; Kocazeybek, Bekir; Demirci, Mehmet; Caliskan, Reyhan; Kepil, Nuray; Uysal, Hayriye Kirkoyun; Dinc, HARİKA ÖYKÜ; Saribas, Suat; Ergin, Sevgi; Erzin, Yusuf; Tasci, İhsan; Erdamar, Sibel; Demirdag, Cetin; Tokman, Hrisi Bahar; DİNÇ, HARİKA ÖYKÜ
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    Problems encountered in conventional HIV 1/2 algorithms: Lack of necessity for immunoblot assays to confirm repeated ELISA reactive results
    (2018-06-01T00:00:00Z) Yuksel, Pelin; Saribas, Suat; Kuskucu, Mert; Mutcali, Sibel Islak; Kosan, Erdogan; Habip, Zafer; Demirci, Mehmet; Kara, Eda Salihoglu; Birinci, Ilhan; Caliskan, Reyhan; Dinc, HARİKA ÖYKÜ; Midilli, Kenan; Ziver, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    Background: The use of conventional (serologically based) HIV 1/2 diagnostic algorithms has become controversial in recent years.
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    Diagnostic performance of the RT-qPCR method targeting 85B mRNA in the diagnosis of pulmonary Mycobacterium tuberculosis infection
    (2018-09-01T00:00:00Z) Demirci, Mehmet; Saribas, Suat; Ozer, Nigar; TOPRAK, Sezer; CAGLAR, Emel; ORTAKOYLU, Gonenc; Yuksel, PELİN; Ayaz, Gulsel; Tokman, Hrisi B.; Uysal, Omer; Dinc, HARİKA ÖYKÜ; ZİVER, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; UYSAL, ÖMER; DİNÇ, HARİKA ÖYKÜ
    Background: Several nucleic acid amplification techniques (IS6110, 16S rRNA, and 85B mRNA) were developed for the rapid, direct detection of Mycobacterium tuberculosis. We aimed to assess the diagnostic performance of 85B mRNA-based RT-qPCR by comparing with the real-time PCR COBAS TagMan MTB Kit while using the BACTEC MGIT 960 method as the gold standard.
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    PublicationOpen Access
    Evaluation of the Diagnostic Performance of Different Principles of SARS-CoV-2 Commercial Antibody Tests in COVID-19 Patients
    (2021-04-01T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; Ozdemir, Yusuf Emre; ALKAN, Sena; DALAR, ZEYNEP GÜNGÖRDÜ; Gareayaghi, Nesrin; SİREKBASAN, SERHAT; TOK, Yeşim; KUŞKUCU, Mert Ahmet; KARAALİ, Rıdvan; Ozbey, Dogukan; AYGÜN, Gökhan; MİDİLLİ, Kenan; Kocazeybek, Bekir; DİNÇ, HARİKA ÖYKÜ
    Following the emergence of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and using only PCR for diagnosis, antibody tests have been rapidly developed by various commercial companies. There are differences between the sensitivity and specificity of these tests due to the usage of different viral target proteins and antibody subclasses. In order to evaluate the diagnostic use of these tests, we aimed to examine the diagnostic performance, especially sensitivity and specificity, of SARS-CoV-2 IgM, IgA and IgG tests of various companies (Abbott, Roche, Euroimmun, Dia.Pro, Anshlabs, Vircell, UnScience and RedCell), which have different principles (ECLIA/CLIA, EIA, LFA). Current (n= 180) and past (n= 180) COVID-19 patients with clinical and molecular diagnosis of COVID-19 admitted to Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine Hospital, Pandemic Polyclinic with suspected COVID-19 infection, were included in our study. The patients admitted within the first 3 weeks after the onset of symptoms were included in the current patient group, and those admitted at the third and after the third week were included in the past patient group. Serum samples (n= 180) obtained from Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Blood Center between April and June 2018 before the COVID-19 pandemic were included in the study as a control group. All the tests included in our study were studied with the recommendations of the manufacturer companies. Between the IgG detection tests with different principles in patients with past COVID-19, the sensitivity and specificity values of the most effective tests were; 86.7%/99.4% (Abbott), 86.1%/98.9% (Dia.Pro), 91.3%/95% (RedCell). Between the IgM detection tests with different principles in current COVID-19 patients, the sensitivity and specificity values were; 67.8%/99.4% (Abbott), 68.9%/98.6% (Vircell), 50%/97.5% (RedCell). Abbott IgM with a kappa coefficient of 0.67 and Vircell IgM + IgA test with a kappa coefficient of 0.65 showed the best fit in patients with current COVID-19 infection. In patients with past COVID-19, Abbott IgG with 0.86 kappa coefficient and Dia.Pro IgG test with 0.85 kappa coefficient showed the best match. Due to the low sensitivity of IgM detection antibody tests, they should not be preferred instead of real-time reverse transcriptase polymerase chain reaction in routine diagnosis. IgG detection tests may be preferred to detect the antibody response and the titers in people who have had COVID-19 for population seroprevalence and especially therapeutic immune plasma production. However, it is thought that the combined use of both ECLIA/CLIA-based and EIA/ELISA-based tests together may be more effective in routine use for SARS-CoV-2 IgG tests.
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    Evaluation of Adenovirus-36 (Ad-36) antibody seropositivity and adipokine levels in obese children
    (2017-07-01T00:00:00Z) Kocazeybek, Bekir; Dinc, HARİKA ÖYKÜ; Ergin, Sevgi; Saribas, Suat; Ozcabi, Bahar Taskm; Cizmecigil, Utku; Altan, Eda; Atalik, Keyser; Yuksel, Pelin; Taner, Zeynep; Karakullukcu, Asiye; Sirekbasan, Serhat; Turan, Nuri; Cagatay, Penbe; Imamova, Nergiz; Evliyaoglu, Olcay; Yilmaz, Huseyin; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
    Adenovirus 36 (Ad-36) has recently been suggested as a possible contributor to the current obesity epidemic. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children, as well as investigate the role of serum leptin and lipid levels in Ad-36-obesity. Seventy-one obese children and 62 non-obese children were included as the patient group (PG), including the healthy control group (HCG), respectively. Simultaneously, Ad-36 antibodies and adipokine levels were assessed with serum neutralization assays (SNA) and ELISA. Ad-36 antibody was detected in 9 patients (12.7%) and 1 patient (1.6%) in both the PG and HCG, respectively, while a significant difference was detected between groups (p < 0.05). Although serum LDL, total cholesterol, triglycerides and leptin levels were detected significantly higher, adiponectin level was detected paradoxically lower in the PG. However, a significant difference was not detected for lipids and leptin levels; adiponectin levels were found to be significantly lower in Ad-36 antibody-positive PG (p < 0.05).
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    PublicationOpen Access
    Anti-SARS-CoV-2 IgG and Neutralizing Antibody Levels in Patients with Past COVID-19 Infection: A Longitudinal Study.
    (2022-04-05T00:00:00Z) Dinç, HARİKA ÖYKÜ; Demirci, Mehmet; Özdemir, Yusuf Emre; Sirekbasan, Serhat; Aktaş, Ayse Nur; Karaali, Rıdvan; Tuyji Tok, Yeşim; Özbey, Doğukan; Akçin, Rüveyda; Gareayaghi, Nesrin; Kuşkucu, Mert Ahmet; Midilli, Kenan; Aygün, Gökhan; Sarıbaş, Suat; Kocazeybek, Bekir; DİNÇ, HARİKA ÖYKÜ
    Background: Monitoring the longevity of immunoglobulin G (IgG) responses following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections is vital to understanding the role of antibodies in preventing infection. Aims: To determine the quantitative IgG responses specific to the Spike-S1 (S1) receptor-binding domain (S1/RBD) region of the virus in serum samples taken between 4 weeks and 7 months after polymerase chain reaction (PCR) positivity in patients who are diagnosed with coronavirus disease-2019 (COVID-19). Study design: A longitudinal study. Methods: This study included 113 patients with a clinical and molecular diagnosis of COVID-19. The first and second serum samples were taken 1 and 7 months, respectively, after the PCR positivity. S1/RBD-specific IgG antibody response was assayed using anti-SARS-CoV- 2 QuantiVac ELISA (IgG) kit (Euroimmun, Lübeck, Germany). The neutralizing antibodies were investigated in 57 patients whose IgG test results were above the cut-off value. Results: In 57 patients with SARS-CoV-2 IgG, the anti-SARS-CoV-2 IgG quantitative antibody levels significantly decreased after 7 months (Z = −2.197, p = 0.028). A correlation was detected between the anti-SARS-CoV-2 IgG and nAb percent inhibition (IH%) levels detected in 1 month (rs = 0.496, p < 0.001), but without significant correlation in serum samples taken on 7 months. The nAb IH% levels of the first and second were compared for COVID-19 severity and revealed no statistical difference (p = 0.256). In the second serum sample, the nAb IH%s of patients with moderate COVID-19 showed a statistically significant difference from patients with mild COVID-19 (p = 0.018), but without significant differences between severe and moderate or mild COVID-19. Conclusion: SARS-CoV-2 quantitative IgG antibody titers are significantly reduced at long-term follow-up (> 6 months). Due to the limited information on seroconversion, comprehensive studies should be conducted for long-term follow-up of the immune response against SARS-CoV-2.