Person: DİNÇ, HARİKA ÖYKÜ
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Publication Open Access Antibody Response to SARS-CoV-2 Vaccines in People with Severe Obesity(2022-07-01T00:00:00Z) KARA, ZEHRA; Akcin, Ruveyda; DEMİR, Ahmet Numan; DİNÇ, HARİKA ÖYKÜ; Taskin, Halit Eren; KOCAZEYBEK, BEKİR SAMİ; YUMUK, VOLKAN DEMİRHAN; DİNÇ, HARİKA ÖYKÜAim: Obesity is a disease complicating the course of COVID-19 and SARS-CoV-2 vaccine effectiveness in adults with obesity may be compromised. Our aim is to investigate the spike-protein receptor-binding domain antibody titers against BNT162b2 mRNA and inactivated SARS-CoV-2 (CoronaVac) vaccines in people with severe obesity. It is anticipated that the results to be obtained may provide invaluable information about future SARS-CoV-2 vaccination strategies in this vulnerable population. Methods: A total of 124 consecutive patients with severe obesity (age > 18 years, BMI ≥ 40 kg/m2) presenting between August and November 2021 were enrolled. The normal weight control group (age > 18, BMI 18.5-24.9 kg/m2) was recruited from 166 subjects who visited the vaccination unit. SARS-CoV-2 spike-protein antibody titers were measured in patients with severe obesity and in normal weight controls who received two doses of BNT162b2, or CoronaVac vaccines. SARS-CoV-2 IgG Nucleocapsid Protein antibody (NCP Ab) testing was performed to discover prior SARS-CoV-2 infection. Blood samples were taken from individuals at 4th week and after 2nd dose of vaccination. SARS-CoV-2 IgG antibody titers were determined by quantitative serological methods. Results: A total of 290 individuals (220 female, 70 male) who have received two doses of BNT162b2 or CoronaVac vaccines were enrolled in the study. Seventy had prior SARS-CoV-2 infection. In 220 subjects (non-prior infection) vaccinated with BNT162b2 or CoronaVac, the antibody titers against SARS-CoV-2 spike antigen of patients with severe obesity were significantly lower than normal weight controls (p = 0.001, p = 0.001 respectively). In seventy subjects with prior SARS-CoV-2 infection, spike antigen antibody titers in patients with severe obesity, vaccinated with BNT162b2 or CoronaVac, were not significantly different from normal weight controls (p = 0.1, p = 0.1 respectively). In patients with severe obesity, with and without prior SARS-CoV-2 infection, spike antigen antibody levels of those vaccinated with BNT162b2 were found to be significantly higher than those vaccinated with CoronaVac (p = 0.043, p < 0.001 respectively). Conclusion: Patients with severe obesity generated significantly reduced antibody titers against SARS-CoV-2 spike antigen after CoronaVac and BNT162b2 vaccines compared to people with normal weight. Antibody levels in patients with severe obesity vaccinated with BNT162b2 were found to be significantly higher than those vaccinated with CoronaVac. People living with severe obesity should be prioritized for COVID-19 vaccination and BNT162b2 vaccine may be recommended for this vulnerable population.Publication Metadata only Risk factors influencing seroconversion after inactive SARS-CoV-2 vaccination in people living with obesity(2022-08-01T00:00:00Z) KARA, ZEHRA; Akcin, Rueveyda; DEMİR, Ahmet Numan; Dinc, Harika Oyku; KOCAZEYBEK, BEKİR SAMİ; YUMUK, VOLKAN DEMİRHAN; DİNÇ, HARİKA ÖYKÜIntroductionPublication Metadata only Retrospective Evaluation of Toxoplasma gondii, Rubella and Cytomegalovirus Seropositivity and Avidity Test Results in Patients Admitted to İU-C Cerrahpaşa Medical Faculty Hospital Between 2013-2018(2020-01-01T00:00:00Z) Demir, Esra; DİNÇ, HARİKA ÖYKÜ; Özbey, Doğukan; AKKUŞ, SEHER; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜPublication Open Access Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs(2022-10-01T00:00:00Z) SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜ; BALKAN, İLKER İNANÇ; CAN, GÜNAY; Ozbey, Dogukan; BEYTUR, AYŞE NUR; KESKİN, ELİF; BUDAK, Beyhan; Aydogan, Okan; METE, BİLGÜL; KARAALİ, RIDVAN; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜThe objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after Coro-naVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, espe-cially in individuals with risk factors.Publication Metadata only İ.Ü. Cerrahpaşa Tıp Fakültesi Tıbbi Mikrobiyoloji Seroloji/Elısa Ünitesine Gelen Serumlarda EBV Seropozitifliğinin Retrospektif Olarak 1,5 Yıllık Seroepidemiyolojik Değerlendirilmesi(2016-02-25T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; bakır, esra; YÜKSEL MAYDA, PELİN; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİNPublication Metadata only Association of adenovirus 36 and gynecomastia development: A case-control study(2021-01-01T00:00:00Z) SİREKBASAN, SERHAT; DİNÇ, HARİKA ÖYKÜ; PİLANCI, ÖZGÜR; KESKİN, MELİKE; ALTAN TARAKCI, EDA; Çortuk, Oğuz; TURAN, NURİ; VELİDEDEOĞLU, MEHMET; KÖKSAL, SERDAR SELÇUK; Sarıbaş, Abdulkerim Suat; ERGİN, SEVGİ; YILMAZ, HÜSEYİN; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜPublication Open Access Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required(2022-03-01T00:00:00Z) BALKAN, İLKER İNANÇ; DİNÇ, HARİKA ÖYKÜ; CAN, GÜNAY; KARAALİ, RIDVAN; Ozbey, Dogukan; ÇAĞLAR, BİLGE; BEYTUR, AYŞE NUR; KESKİN, ELİF; BUDAK, Beyhan; Aydogan, Okan; METE, BİLGÜL; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜAims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital.Publication Metadata only SARS-CoV-2 IgG Antibody Levels After Inactivated Vaccine (CoronaVac) among Elderly(2022-06-01T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; BALKAN, İLKER İNANÇ; budak, beyhan; DEMİRCİ, MEHMET; ÖZBEY, DOĞUKAN; KARAALİ, RIDVAN; METE, BİLGÜL; CAN, GÜNAY; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜPublication Metadata only The Frequency and Results of QuantiFERON-TB Gold Test in Parallel with the Place of the Clinical Usage in the Cerrahpaşa Medical Faculty Clinics: A 2-year Retrospective Evaluation(2020-10-01T00:00:00Z) SİREKBASAN, SERHAT; DİNÇ, HARİKA ÖYKÜ; Özbey, Doğukan; AKKUŞ, SEHER; Sarıbaş, Suat; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜPublication Metadata only 2015-2018 Dönemi HIV Tarama ve Doğrulama Verilerinin Seroepidemiyolojik Değerlendirilmesi(2019-03-13T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; Özbey, Doğukan; YÜKSEL MAYDA, PELİN; KUŞKUCU, MERT AHMET; MİDİLLİ, KENAN; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN