Person: DİNÇ, HARİKA ÖYKÜ
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Publication Open Access Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs(2022-10-01T00:00:00Z) SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜ; BALKAN, İLKER İNANÇ; CAN, GÜNAY; Ozbey, Dogukan; BEYTUR, AYŞE NUR; KESKİN, ELİF; BUDAK, Beyhan; Aydogan, Okan; METE, BİLGÜL; KARAALİ, RIDVAN; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜThe objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after Coro-naVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, espe-cially in individuals with risk factors.Publication Open Access Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required(2022-03-01T00:00:00Z) BALKAN, İLKER İNANÇ; DİNÇ, HARİKA ÖYKÜ; CAN, GÜNAY; KARAALİ, RIDVAN; Ozbey, Dogukan; ÇAĞLAR, BİLGE; BEYTUR, AYŞE NUR; KESKİN, ELİF; BUDAK, Beyhan; Aydogan, Okan; METE, BİLGÜL; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜAims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital.Publication Metadata only SARS-CoV-2 IgG Antibody Levels After Inactivated Vaccine (CoronaVac) among Elderly(2022-06-01T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; BALKAN, İLKER İNANÇ; budak, beyhan; DEMİRCİ, MEHMET; ÖZBEY, DOĞUKAN; KARAALİ, RIDVAN; METE, BİLGÜL; CAN, GÜNAY; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜPublication Metadata only Sağlık Çalışanlarında İnaktif COVID-19 Aşısına Karşı Hümoral İmmun Yanıtın Değerlendirilmesi(2022-03-09T00:00:00Z) BALKAN, İLKER İNANÇ; DİNÇ, HARİKA ÖYKÜ; CAN, GÜNAY; KARAALİ, RIDVAN; ÖZBEY, DOĞUKAN; ÇAĞLAR, BİLGE; AKTAŞ, AYŞE NUR; BUDAK, Beyhan; AYDOĞAN, OKAN; METE, BİLGÜL; ERGİN, SEVGİ; KOCAZEYBEK, BEKİR SAMİ; SALTOĞLU, NEŞE; DİNÇ, HARİKA ÖYKÜPublication Metadata only SARS-CoV-2 ile İlgili Farklı Prensipli Ticari Antikor Testlerinin Tanısal Performansları(2022-03-20T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; ÖZDEMİR, YUSUF EMRE; KARAALİ, RIDVAN; Gareayaghi, Nesrin; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜPublication Metadata only Sağlık Çalışanlarında İnaktif Coronavac Aşısının Etkinliği: İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi Verileri(2021-05-27T00:00:00Z) DİNÇ, HARİKA ÖYKÜ; Budak, Beyhan; ÖZBEY, DOĞUKAN; TOK, YEŞİM; KARAALİ, RIDVAN; ÇAĞLAR, BİLGE; KUŞKUCU, MERT AHMET; METE, BİLGÜL; BALKAN, İLKER İNANÇ; MİDİLLİ, KENAN; ERGİN, SEVGİ; CAN, GÜNAY; SALTOĞLU, NEŞE; KOCAZEYBEK, BEKİR SAMİ; DİNÇ, HARİKA ÖYKÜ