Person:
İNCE, ALİ TÜZÜN

Profile Picture
Google ScholarScopusORCIDPublons
Status
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
ALİ TÜZÜN
Last Name
İNCE
Name
Email Address
Birth Date

Filters

2010 - 2019262020 - 20227
Reset filters

Settings

Type: Article × Rights: info:eu-repo/semantics/openAccess ×

Search Results

Now showing 1 - 10 of 33
  • No Thumbnail Available
    PublicationMetadata only
    Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases.
    (2022-05-12T00:00:00Z) Kiss, Szabolcs; Kiss, Szabolcs; Pintér, József; Molontay, Roland; Nagy, Marcell; Farkas, Nelli; Farkas, Nelli; Sipos, Zoltán; Sipos, Zoltán; Pecze, László; Pecze, László; Földi, Mária; Földi, Mária; Vincze, Áron; Vincze, Áron; Takács, Tamás; Takács, Tamás; Halász, Adrienn; Halász, Adrienn; Faluhelyi, Nándor; Faluhelyi, Nándor; Farkas, Orsolya; Farkas, Orsolya; Váncsa, Szilárd; Váncsa, Szilárd; Erőss, Bálint; Erőss, Bálint; Párniczky, Andrea; Párniczky, Andrea; Hegyi, Péter; Hegyi, Péter; Fehérvári, Péter; Fehérvári, Péter; Czakó, László; Czakó, László; Izbéki, Ferenc; Izbéki, Ferenc; Boros, Eszter; Boros, Eszter; Hamvas, József; Hamvas, József; Varga, Márta; Varga, Márta; Mickevicius, Artautas; Mickevicius, Artautas; Nagy, Rita; Nagy, Rita; Bunduc, Stefania; Bunduc, Stefania; Hegyi, Péter Jenő; Hegyi, Péter Jenő; Márta, Katalin; Márta, Katalin; Borka, Katalin; Borka, Katalin; Doros, Attila; Doros, Attila; Hosszúfalusi, Nóra; Hosszúfalusi, Nóra; Zubek, László; Zubek, László; Molnár, Zsolt; Molnár, Zsolt; Szentesi, Andrea; Szentesi, Andrea; Bajor, Judit; Gódi, Szilárd; Sarlós, Patrícia; Czimmer, József; Szabó, Imre; Pár, Gabriella; Illés, Anita; Hágendorn, Roland; Németh, Balázs Csaba; Kui, Balázs; Illés, Dóra; Gajdán, László; Dunás-Varga, Veronika; Fejes, Roland; Papp, Mária; Vitális, Zsuzsanna; Novák, János; Török, Imola; Macarie, Melania; Ramírez-Maldonado, Elena; Sallinen, Ville; Galeev, Shamil; Bod, Barnabás; Ince, ALİ TÜZÜN; Pécsi, Dániel; Varjú, Péter; Juhász, Márk Félix; Ocskay, Klementina; Mikó, Alexandra; Szakács, Zsolt; İNCE, ALİ TÜZÜN
  • Thumbnail Image
    PublicationOpen Access
    The relationship between serum histon levels and the severity of acute pancreatitis.
    (2019-09-01) Biberci, Keskin; Şentürk, H; Köker, İH; Sümbül, Gültepe; İnce, AT; İNCE, ALİ TÜZÜN; SÜMBÜL, BİLGE; ŞENTÜRK, HAKAN
    Background/Aims: Despite various scoring systems and imaging methods, it is hard to predict the severity and the course of acute pancreatitis (AP), thereby necessitating better and more reliable markers. Since inflammation plays a key role in the pathogenesis of AP, we sought to determine whether histone, which is a novel inflammatory marker, may play a role in the prediction of severity and prognosis. Materials and Methods: A total of 88 consecutive adult patients (>18 years) with a first AP episode were prospectively enrolled in the study. Severe AP was defined as having a revised Atlanta score >3 in the first 48 h after admission. Circulating histone 3 and 4 levels were measured using the enzyme-linked immunosorbent assay method. Results: Eighty-eight consecutive adult patients with a first episode of AP were divided into two groups according to severity, in which 56 (63.6%) were assigned to the mild AP group and 32 (36.4%) to the severe AP group. White blood cell, hemoglobin, creatinine, and aspartate aminotransferase levels were significantly higher in the severe AP group. However, there was no difference in serum histone levels between the groups, and there was no correlation between revised Atlanta score and serum histone levels either. Conclusion: Serum histone levels did not significantly differ between the severe and mild AP groups. Therefore, these markers may not provide additional benefit for determining the severity of AP.
  • Thumbnail Image
    PublicationOpen Access
    Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening
    (2014-01-01) Ince, ALİ TÜZÜN; BAYSAL, Birol; KAYAR, Yusuf; Arabaci, ELİF; Bilgin, MEHMET; HAMDARD, Jamshid; YAY, Adnan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARABACI, ELİF; BİLGİN, MEHMET; ŞENTÜRK, HAKAN
    Introduction and objective: Colonic wall thickening is a common condition in a number of benignant and malignant diseases. This study investigated the accuracy of radiological diagnoses in patients diagnosed with colonic wall thickening using multislice CT (MDCT). Materials and method: Files of patients with colonic wall thickening diagnosed with 64-slice MDCT were reviewed retrospectively. The colonoscopy results of these patients were grouped under neoplastic process (cancer and adenomatous polyp), inflammatory bowel disease (IBD), diverticulitis and other etiology (nonspecific events, ischemic colitis, solitary rectal ulcer, external compression, secondary to volvulus and radiotherapy), and the results were statistically evaluated. p values < 0.05 were considered statistically significant. Results: The study was performed on 505 files (290 males [57.4%], 215 females [42.6%], mean age: 49.15 ± 18.4 years). CT and colonoscopic diagnoses were reviewed and the following CT to colonoscopy ratios was observed: neoplastic process: 44.4% vs. 40.2%; IBD: 42.4% vs. 42.4%; diverticulitis: 4% vs. 4.2%; other etiology: 9.3% vs. 3.2%. Colonoscopy failed to identify pathology in 9.9% of the patients. The sensitivity, specificity, PPV, NPV and accuracy of CT were 95.6%, 90.4%, 87.1%, 96.8% and 92.4%, respectively, in detecting neoplastic processes; 97.2%, 97.9%, 97.2%, 97.9% and 97.6%, respectively, in detecting IBD; 90.5%, 99.8%, 95%, 99.6% and 99.4%, respectively, in detecting diverticulitis, and 50%, 96,7%, 62.5%, 94.6% and 92%, respectively, in detecting other etiology. Conclusion: While, accuracy of 64 slice-CT in diagnosing colonic wall thickenings secondary especially to neoplastic processes, IBD and diverticulitis was significantly higher, but differential diagnosis is challenging in pathologies due to other etiologies.
  • Thumbnail Image
    PublicationOpen Access
    Role of gut microbiota: Obesity and NAFLD
    (2014-04-01) GANGARAPU, Venkatanarayana; YILDIZ, Kemal; Ince, ALİ TÜZÜN; BAYSAL, Birol; İNCE, ALİ TÜZÜN
    Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD.
  • No Thumbnail Available
    PublicationMetadata only
  • Thumbnail Image
    PublicationOpen Access
    Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit
    (2018-11-01) kayar, yusuf; Baysal, Birol; Tozlu, Mukaddes; ŞENTÜRK, hakan; Atay, Musa; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜN
    Background: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings. Materials and Methods: This prospective observational study included 180 patients with mild AP according to the harmless acute pancreatitis score (HAPS) and Imrie score. The relationships of biochemical parameters with the changes in the Balthazar score and clinical course were examined. Results: The study included 180 patients (111 females, 69 males; mean age: 53.9 ± 17.2 years; range: 17–92 years). The etiology was biliary in 118 (65%) patients and remained undetermined in 38 (21.1%) patients. Computed tomography (CT) performed within the first 12 h revealed mild and moderate AP in 159 (88.3%) and 21 (11.7%) patients, respectively. CT repeated at 72 h revealed mild, moderate, and severe AP in 155 (86.1%), 24 (13.3%), and 1 (0.6%) patients, respectively. Comparisons between stages A + B + C and D + E showed significant differences in the amylase levels on day 1 and 3, and in C-reactive protein on day 3. Also, in stage D and E disease, narcotic analgesic intake, oral intake onset time, and pain were significantly higher. Conclusion: There were no significant changes in the CT findings of patients with mild AP at 12 and 72 h. Most patients (n = 179; 99.4%) recovered uneventfully. Patients with mild pancreatitis according to the HAPS and Imrie scores can be considered for outpatient management. The recovery is longer in stage D and E disease.
  • Thumbnail Image
    PublicationOpen Access
    Initial Renal Function (eGFR) Is a Prognostic Marker of Severe Acute Pancreatitis: A Cohort-Analysis of 1,224 Prospectively Collected Cases
    (2021-08-01T00:00:00Z) İnce, Ali Tüzün; Farkas, Nelli; Németh, Dávid; Hamar, Peter; Hegyi, Peter; Hágendorn, Roland; Czakó, László; Izbéki, Ferenc; Galeev , Shamil I; Papp, Mária; Faluhelyi, Nandor; Gombos, Katalin; Nagy, Tamás; Szénási , Gábor; Vincze, Aron; Illés , Dóra; Hegyi, Péter Jenő; Szentesi, Andrea; Párniczky, Andrea; Hamvas , József; Varga, Marta; İNCE, ALİ TÜZÜN
    Background:Acute pancreatitis (AP) is a life-threatening disease. We aimed to explore the prognostic relevance of renal function based on estimated glomerular filtration rate (eGFR).Methods:A prospective registry of AP patients was established by the Hungarian Pancreatic Study Group. Data of 1,224 consecutive patients were collected between 2012 and 2017. Patients were divided into 3 groups according to their eGFR measured within 24 h of hospitalization:normalrenal function: >90 mL/min,mildto moderate renal functionalimpairment: 30–90 mL/min andsevererenaldysfunction: <30 mL/min. Associations of eGFR with outcome (survival, length of hospitalization, AP severity, blood glucose), inflammatory markers (erythrocyte sedimentation rate, white blood cell count), anemia and organ failure (heart, kidney, liver) were analyzed.Results:Death, longer hospitalization and severe AP, but not the cause of AP, were significantly associated with lower eGFR. The inflammatory markers (CRP, WBC count) but not anemia (Hb, Htk) were closely associated with severe renal dysfunction. Renal function was associated with heart and renal failure but not with other complications of AP such as respiratory failure, local pancreatic complications, diabetes or peptic ulcer. eGFR was not associated with liver damage (ALAT, γ-GT) or liver function (serum bilirubin) although biliary complications, alcohol and metabolic syndrome were the most common etiologies of AP.Conclusions:Our study suggests a useful prognostic value ofinitialeGFR in AP patients. Even mild eGFR reduction predicted mortality, severity of AP and the length of hospitalization. Thus, precise evaluation of renal function should be considered for assessing AP severity and outcome.
  • Thumbnail Image
    PublicationOpen Access
    Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model.
    (2021-01-14T00:00:00Z) Hegyi, Péter J; Soós, Alexandra; Tóth, Emese; Ébert, Attila; Venglovecz, Viktória; Márta, Katalin; Mátrai, Péter; Mikó, Alexandra; Bajor, Judit; Sarlós, Patrícia; Vincze, Áron; Halász, Adrienn; Izbéki, Ferenc; Szepes, Zoltán; Czakó, László; Kovács, György; Papp, Mária; Dubravcsik, Zsolt; Varga, Márta; Hamvas, József; Németh, Balázs C; Macarie, Melania; Ince, ALİ TÜZÜN; Bordin, Dmitry S; Dubtsova, Elena A; Kiryukova, Mariya A; Khatkov, Igor E; Bideeva, Tanya; Mickevicius, Artautas; Ramírez-Maldonado, Elena; Sallinen, Ville; Erőss, Bálint; Pécsi, Dániel; Szentesi, Andrea; Párniczky, Andrea; Tiszlavicz, László; Hegyi, Péter; İNCE, ALİ TÜZÜN
    Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
  • Thumbnail Image
    PublicationOpen Access
    A Multicenter, International Cohort Analysis of 1435 Cases to Support Clinical Trial Design in Acute Pancreatitis.
    (2019-09-04T00:00:00Z) Farkas, N; Hanák, L; Mikó, A; Bajor, J; Sarlós, P; Czimmer, J; Vincze, Á; Gódi, S; Pécsi, D; Varjú, P; Márta, K; Hegyi, PJ; Erőss, B; Szakács, Z; Takács, T; Czakó, L; Németh, B; Illés, D; Kui, B; Darvasi, E; Izbéki, F; Halász, A; Dunás-Varga, V; Gajdán, L; Hamvas, J; Papp, M; Földi, I; Fehér, KE; Varga, M; Csefkó, K; Török, I; Hunor-Pál, F; Mickevicius, A; Maldonado, ER; Sallinen, V; Novák, J; Ince, ALİ TÜZÜN; Galeev, S; Bod, B; Sümegi, J; Pencik, P; Szepes, A; Szentesi, A; Párniczky, A; Hegyi, P; İNCE, ALİ TÜZÜN
    Background: C-reactive protein level (CRP) and white blood cell count (WBC) have been variably used in clinical trials on acute pancreatitis (AP). We assessed their potential role. Methods: First, we investigated studies which have used CRP or WBC, to describe their current role in trials on AP. Second, we extracted the data of 1435 episodes of AP from our registry. CRP and WBC on admission, within 24 h from the onset of pain and their highest values were analyzed. Descriptive statistical tools as Kruskal-Wallis, Mann-Whitney U, Levene's F tests, Receiver Operating Characteristic (ROC) curve analysis and AUC (Area Under the Curve) with 95% confidence interval (CI) were performed. Results: Our literature review showed extreme variability of CRP used as an inclusion criterion or as a primary outcome or both in past and current trials on AP. In our cohort, CRP levels on admission poorly predicted mortality and severe cases of AP; AUC: 0.669 (CI:0.569-0.770); AUC:0.681 (CI: 0.601-0.761), respectively. CRP levels measured within 24 h from the onset of pain failed to predict mortality or severity; AUC: 0.741 (CI:0.627-0.854); AUC:0.690 (CI:0.586-0.793), respectively. The highest CRP during hospitalization had equally poor predictive accuracy for mortality and severity AUC:0.656 (CI:0.544-0.768); AUC:0.705 (CI:0.640-0.769) respectively. CRP within 24 h from the onset of pain used as an inclusion criterion markedly increased the combined event rate of mortality and severe AP (13% for CRP > 25 mg/l and 28% for CRP > 200 mg/l). Conclusion: CRP within 24 h from the onset of pain as an inclusion criterion elevates event rates and reduces the number of patients required in trials on AP.
  • Thumbnail Image
    PublicationOpen Access
    Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma
    (2015-01-01) Ince, ALİ TÜZÜN; YILDIZ, Kemal; GANGARAPU, Venkatanarayana; KAYAR, Yusuf; BAYSAL, Birol; KARATEPE, Oguzhan; Kemik, Ahu Sarbay; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
    Aim: Cholangiocarcinoma is generally detected late in the course of disease, and current diagnostic techniques often fail to differentiate benign from malignant disease. Ongoing biomarker studies for early diagnosis of cholangiocarcinoma are still continues. By this study, we analyzed the roles of serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma. Materials and methods: The 113 patients (55 males, 58 females) were included; 33 diagnosed with cholangiocarcinoma (malignant group) and 80 diagnosed with choledocholithiasis (benign group). MMP-9 and TIMP-1 concentrations were analyzed in serum and bile and compared in the malignant and benign groups. Results were evaluated statistically. Results: Biliary MMP-9 concentrations were significantly higher (576 ± 209 vs. 403 ± 140 ng/ml, p < 0.01) and biliary TIMP-1 concentrations were significantly lower (22.4 ± 4.9 vs. 29.4 ± 6.1 ng/ml, p < 0.01) in the malignant than in the benign group. In contrast, serum MMP-9 and TIMP-1 concentrations were similar in the two groups. Receiver operating curve analysis revealed that the areas under the curve of bile MMP-9 and TIMP-1 were significantly higher than 0.5 (p < 0.001). The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and accuracy were 0.94, 0.32, 0.36, 0.93, 1.40, 0.19 and 0.5 for biliary MMP-9, respectively, and 0.97, 0.36, 0.39, 0.97, 1.5, 0.08 and 0.54 for biliary TIMP-1, respectively. Conclusion: Serum and biliary MMP-9 and TIMP-1 tests do not appear to be useful in the diagnosis of cholangiocarcinoma.