Person: İNCE, ALİ TÜZÜN
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Publication Metadata only Preliminary Results of Pigtail Plastic Stent (PPS) and Fully Covered Self Expandable Metallic Stent (FCSEMS) Placement in the Endoscopic Treatment of Pancreatic Fluid Collections(2013-05-01T00:00:00Z) Senturk, Hakan; Kocaman, Orhan; Baysal, Birol; Ince, ALİ TÜZÜN; Danalioglu, Ahmet; Tozlu, Mukaddes; Kocakoc, Ercan; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜNPublication Open Access Thrombotic thrombocytopenic purpura and focal segmental glomerulosclerosis associated with the use of ecstasy(2015-04-01T00:00:00Z) Kayar, Yusuf; Kayar, Nuket Bayram; Gangarapu, Venkatanarayana; İNCE, ALİ TÜZÜNEcstasy is a drug, which causes serious side effects and sometimes it can be lethal. These effects are due to idiosyncratic reactions as a result of various stimulations in adrenergic receptors. Here we present a case of a 36-year-old male patient who was diagnosed with thrombotic thrombocytopenic purpura associated with the use of ecstasy. Plasmapheresis along with methylprednisolone treatment restores patient condition to normal.Publication Metadata only Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases.(2022-05-12T00:00:00Z) Kiss, Szabolcs; Kiss, Szabolcs; Pintér, József; Molontay, Roland; Nagy, Marcell; Farkas, Nelli; Farkas, Nelli; Sipos, Zoltán; Sipos, Zoltán; Pecze, László; Pecze, László; Földi, Mária; Földi, Mária; Vincze, Áron; Vincze, Áron; Takács, Tamás; Takács, Tamás; Halász, Adrienn; Halász, Adrienn; Faluhelyi, Nándor; Faluhelyi, Nándor; Farkas, Orsolya; Farkas, Orsolya; Váncsa, Szilárd; Váncsa, Szilárd; Erőss, Bálint; Erőss, Bálint; Párniczky, Andrea; Párniczky, Andrea; Hegyi, Péter; Hegyi, Péter; Fehérvári, Péter; Fehérvári, Péter; Czakó, László; Czakó, László; Izbéki, Ferenc; Izbéki, Ferenc; Boros, Eszter; Boros, Eszter; Hamvas, József; Hamvas, József; Varga, Márta; Varga, Márta; Mickevicius, Artautas; Mickevicius, Artautas; Nagy, Rita; Nagy, Rita; Bunduc, Stefania; Bunduc, Stefania; Hegyi, Péter Jenő; Hegyi, Péter Jenő; Márta, Katalin; Márta, Katalin; Borka, Katalin; Borka, Katalin; Doros, Attila; Doros, Attila; Hosszúfalusi, Nóra; Hosszúfalusi, Nóra; Zubek, László; Zubek, László; Molnár, Zsolt; Molnár, Zsolt; Szentesi, Andrea; Szentesi, Andrea; Bajor, Judit; Gódi, Szilárd; Sarlós, Patrícia; Czimmer, József; Szabó, Imre; Pár, Gabriella; Illés, Anita; Hágendorn, Roland; Németh, Balázs Csaba; Kui, Balázs; Illés, Dóra; Gajdán, László; Dunás-Varga, Veronika; Fejes, Roland; Papp, Mária; Vitális, Zsuzsanna; Novák, János; Török, Imola; Macarie, Melania; Ramírez-Maldonado, Elena; Sallinen, Ville; Galeev, Shamil; Bod, Barnabás; Ince, ALİ TÜZÜN; Pécsi, Dániel; Varjú, Péter; Juhász, Márk Félix; Ocskay, Klementina; Mikó, Alexandra; Szakács, Zsolt; İNCE, ALİ TÜZÜNPublication Metadata only A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study(2014-05-01) Ince, ALİ TÜZÜN; Senturk, HAKAN; Singh, Vikesh K.; YILDIZ, Kemal; DANALIOGLU, Ahmet; CINAR, Ahmet; Uysal, Omer; KOCAMAN, Orhan; BAYSAL, Birol; Guerakar, Ahmet; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMERBackground/Objectives: Acute pancreatitis (AP) is a disease typically requiring in-hospital treatment. We conducted a trial to assess the feasibility of early discharge from the hospital for patients with mild nonalcoholic acute pancreatitis (NAAP).Publication Open Access The relationship between serum histon levels and the severity of acute pancreatitis.(2019-09-01) Biberci, Keskin; Şentürk, H; Köker, İH; Sümbül, Gültepe; İnce, AT; İNCE, ALİ TÜZÜN; SÜMBÜL, BİLGE; ŞENTÜRK, HAKANBackground/Aims: Despite various scoring systems and imaging methods, it is hard to predict the severity and the course of acute pancreatitis (AP), thereby necessitating better and more reliable markers. Since inflammation plays a key role in the pathogenesis of AP, we sought to determine whether histone, which is a novel inflammatory marker, may play a role in the prediction of severity and prognosis. Materials and Methods: A total of 88 consecutive adult patients (>18 years) with a first AP episode were prospectively enrolled in the study. Severe AP was defined as having a revised Atlanta score >3 in the first 48 h after admission. Circulating histone 3 and 4 levels were measured using the enzyme-linked immunosorbent assay method. Results: Eighty-eight consecutive adult patients with a first episode of AP were divided into two groups according to severity, in which 56 (63.6%) were assigned to the mild AP group and 32 (36.4%) to the severe AP group. White blood cell, hemoglobin, creatinine, and aspartate aminotransferase levels were significantly higher in the severe AP group. However, there was no difference in serum histone levels between the groups, and there was no correlation between revised Atlanta score and serum histone levels either. Conclusion: Serum histone levels did not significantly differ between the severe and mild AP groups. Therefore, these markers may not provide additional benefit for determining the severity of AP.Publication Open Access Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening(2014-01-01) Ince, ALİ TÜZÜN; BAYSAL, Birol; KAYAR, Yusuf; Arabaci, ELİF; Bilgin, MEHMET; HAMDARD, Jamshid; YAY, Adnan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARABACI, ELİF; BİLGİN, MEHMET; ŞENTÜRK, HAKANIntroduction and objective: Colonic wall thickening is a common condition in a number of benignant and malignant diseases. This study investigated the accuracy of radiological diagnoses in patients diagnosed with colonic wall thickening using multislice CT (MDCT). Materials and method: Files of patients with colonic wall thickening diagnosed with 64-slice MDCT were reviewed retrospectively. The colonoscopy results of these patients were grouped under neoplastic process (cancer and adenomatous polyp), inflammatory bowel disease (IBD), diverticulitis and other etiology (nonspecific events, ischemic colitis, solitary rectal ulcer, external compression, secondary to volvulus and radiotherapy), and the results were statistically evaluated. p values < 0.05 were considered statistically significant. Results: The study was performed on 505 files (290 males [57.4%], 215 females [42.6%], mean age: 49.15 ± 18.4 years). CT and colonoscopic diagnoses were reviewed and the following CT to colonoscopy ratios was observed: neoplastic process: 44.4% vs. 40.2%; IBD: 42.4% vs. 42.4%; diverticulitis: 4% vs. 4.2%; other etiology: 9.3% vs. 3.2%. Colonoscopy failed to identify pathology in 9.9% of the patients. The sensitivity, specificity, PPV, NPV and accuracy of CT were 95.6%, 90.4%, 87.1%, 96.8% and 92.4%, respectively, in detecting neoplastic processes; 97.2%, 97.9%, 97.2%, 97.9% and 97.6%, respectively, in detecting IBD; 90.5%, 99.8%, 95%, 99.6% and 99.4%, respectively, in detecting diverticulitis, and 50%, 96,7%, 62.5%, 94.6% and 92%, respectively, in detecting other etiology. Conclusion: While, accuracy of 64 slice-CT in diagnosing colonic wall thickenings secondary especially to neoplastic processes, IBD and diverticulitis was significantly higher, but differential diagnosis is challenging in pathologies due to other etiologies.Publication Metadata only Conventional Video-gastroscopes for the Recognition of Early Gastric Cancers(2011-05-01T00:00:00Z) Ince, ALİ TÜZÜN; SENATES, Ebubekir; BAHADIR, Ozgur; COSGUN, Suleyman; GUNES, Pembegul; YILDIZ, Eray; OVUNC, Ayse Oya Kurdas; İNCE, ALİ TÜZÜNBackground/Aims: To determine the role of conventional video-gastroscopes for detection of early gastric cancers (EGC).Publication Open Access Role of gut microbiota: Obesity and NAFLD(2014-04-01) GANGARAPU, Venkatanarayana; YILDIZ, Kemal; Ince, ALİ TÜZÜN; BAYSAL, Birol; İNCE, ALİ TÜZÜNNon-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD.Publication Metadata only Serum myeloperoxidase, CPK, CK-MB, and cTnI levels in early diagnosis of myocardial ischemia during ERCP; Once or repeated once? Reply(2014-08-01) Ince, ALİ TÜZÜN; BAYSAL, Birol; İNCE, ALİ TÜZÜNPublication Open Access Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit(2018-11-01) kayar, yusuf; Baysal, Birol; Tozlu, Mukaddes; ŞENTÜRK, hakan; Atay, Musa; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜNBackground: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings. Materials and Methods: This prospective observational study included 180 patients with mild AP according to the harmless acute pancreatitis score (HAPS) and Imrie score. The relationships of biochemical parameters with the changes in the Balthazar score and clinical course were examined. Results: The study included 180 patients (111 females, 69 males; mean age: 53.9 ± 17.2 years; range: 17–92 years). The etiology was biliary in 118 (65%) patients and remained undetermined in 38 (21.1%) patients. Computed tomography (CT) performed within the first 12 h revealed mild and moderate AP in 159 (88.3%) and 21 (11.7%) patients, respectively. CT repeated at 72 h revealed mild, moderate, and severe AP in 155 (86.1%), 24 (13.3%), and 1 (0.6%) patients, respectively. Comparisons between stages A + B + C and D + E showed significant differences in the amylase levels on day 1 and 3, and in C-reactive protein on day 3. Also, in stage D and E disease, narcotic analgesic intake, oral intake onset time, and pain were significantly higher. Conclusion: There were no significant changes in the CT findings of patients with mild AP at 12 and 72 h. Most patients (n = 179; 99.4%) recovered uneventfully. Patients with mild pancreatitis according to the HAPS and Imrie scores can be considered for outpatient management. The recovery is longer in stage D and E disease.