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İNCE, ALİ TÜZÜN

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ALİ TÜZÜN
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Author: Senturk, HAKAN ×

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    Role of Serum and Biliary CEA, CA19-9, VEGFR-3 and TAC for Differentation of Malignant and Benign Biliary Obstruction
    (2014-05-01) Ince, ALİ TÜZÜN; YILDIZ, Kemal; BAYSAL, Birol; DANALIOGLU, Ahmet; KOCAMAN, Orhan; TOZLU, Mukaddes; GANGARAPU, Venkatanarayana; KEMIK, Ahu Sarbay; UYSAL, Oemer; Senturk, HAKAN; İNCE, ALİ TÜZÜN; UYSAL, ÖMER; ŞENTÜRK, HAKAN
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    A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study
    (2014-05-01) Ince, ALİ TÜZÜN; Senturk, HAKAN; Singh, Vikesh K.; YILDIZ, Kemal; DANALIOGLU, Ahmet; CINAR, Ahmet; Uysal, Omer; KOCAMAN, Orhan; BAYSAL, Birol; Guerakar, Ahmet; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMER
    Background/Objectives: Acute pancreatitis (AP) is a disease typically requiring in-hospital treatment. We conducted a trial to assess the feasibility of early discharge from the hospital for patients with mild nonalcoholic acute pancreatitis (NAAP).
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    Efficacy of Rifaximin on Circulating Endotoxins and Cytokines in Patients With Non-Alcoholic Fatty Liver
    (2015-04-01) Gangarapu, Venkatanarayana; Ince, Ali T.; BAYSAL, Birol; KAYAR, Yusuf; Senturk, HAKAN; KILIC, Ulkan; GOK, Ozlem; Uysal, Oemer; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMER
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    PublicationOpen Access
    Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening
    (2014-01-01) Ince, ALİ TÜZÜN; BAYSAL, Birol; KAYAR, Yusuf; Arabaci, ELİF; Bilgin, MEHMET; HAMDARD, Jamshid; YAY, Adnan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARABACI, ELİF; BİLGİN, MEHMET; ŞENTÜRK, HAKAN
    Introduction and objective: Colonic wall thickening is a common condition in a number of benignant and malignant diseases. This study investigated the accuracy of radiological diagnoses in patients diagnosed with colonic wall thickening using multislice CT (MDCT). Materials and method: Files of patients with colonic wall thickening diagnosed with 64-slice MDCT were reviewed retrospectively. The colonoscopy results of these patients were grouped under neoplastic process (cancer and adenomatous polyp), inflammatory bowel disease (IBD), diverticulitis and other etiology (nonspecific events, ischemic colitis, solitary rectal ulcer, external compression, secondary to volvulus and radiotherapy), and the results were statistically evaluated. p values < 0.05 were considered statistically significant. Results: The study was performed on 505 files (290 males [57.4%], 215 females [42.6%], mean age: 49.15 ± 18.4 years). CT and colonoscopic diagnoses were reviewed and the following CT to colonoscopy ratios was observed: neoplastic process: 44.4% vs. 40.2%; IBD: 42.4% vs. 42.4%; diverticulitis: 4% vs. 4.2%; other etiology: 9.3% vs. 3.2%. Colonoscopy failed to identify pathology in 9.9% of the patients. The sensitivity, specificity, PPV, NPV and accuracy of CT were 95.6%, 90.4%, 87.1%, 96.8% and 92.4%, respectively, in detecting neoplastic processes; 97.2%, 97.9%, 97.2%, 97.9% and 97.6%, respectively, in detecting IBD; 90.5%, 99.8%, 95%, 99.6% and 99.4%, respectively, in detecting diverticulitis, and 50%, 96,7%, 62.5%, 94.6% and 92%, respectively, in detecting other etiology. Conclusion: While, accuracy of 64 slice-CT in diagnosing colonic wall thickenings secondary especially to neoplastic processes, IBD and diverticulitis was significantly higher, but differential diagnosis is challenging in pathologies due to other etiologies.
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    Low Molecular Weight Heparin Treatment of Acute Severe Pancreatitis: A Randomized, Controlled Study
    (2015-04-01) TOZLU, Mukaddes; KAYAR, Yusuf; BAYSAL, Birol; Ince, ALİ TÜZÜN; KOCAMAN, Orhan; DANALIOGLU, Ahmet; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
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    Helicobacter pylori is undetectable in intraductal papillary mucinous neoplasm
    (2016-09-01) BAYSAL, Birol; Ince, ALİ TÜZÜN; Gucin, ZÜHAL; Malya, FATMA ÜMİT; TOZLU, Mukaddes; Senturk, HAKAN; BAĞCI, PELİN; Celikel, Cigdem Ataizi; Gultepe, Bilge; OZKARA, Selvinaz; PASAOGLU, Esra; DURSUN, Nevra; OZGUVEN, Banu Yilmaz; TUNCEL, Deniz; İNCE, ALİ TÜZÜN; SÜMBÜL, BİLGE; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİT; ŞENTÜRK, HAKAN
    Background: About half of the world population is infected with Helicobacter pylori (H. pylori), a bacterium associated with gastric cancer and considered to be a risk factor for pancreatic ductal adenocarcinoma. Whether the bacterium is associated with intraductal papillary mucinous neoplasm, believed to be a precursor of pancreatic ductal adenocarcinoma, is unknown. The aim of this study was to investigate the presence of H. pylori DNA in tissue sections of intraductal papillary mucinous neoplasm.
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    PublicationOpen Access
    Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma
    (2015-01-01) Ince, ALİ TÜZÜN; YILDIZ, Kemal; GANGARAPU, Venkatanarayana; KAYAR, Yusuf; BAYSAL, Birol; KARATEPE, Oguzhan; Kemik, Ahu Sarbay; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
    Aim: Cholangiocarcinoma is generally detected late in the course of disease, and current diagnostic techniques often fail to differentiate benign from malignant disease. Ongoing biomarker studies for early diagnosis of cholangiocarcinoma are still continues. By this study, we analyzed the roles of serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma. Materials and methods: The 113 patients (55 males, 58 females) were included; 33 diagnosed with cholangiocarcinoma (malignant group) and 80 diagnosed with choledocholithiasis (benign group). MMP-9 and TIMP-1 concentrations were analyzed in serum and bile and compared in the malignant and benign groups. Results were evaluated statistically. Results: Biliary MMP-9 concentrations were significantly higher (576 ± 209 vs. 403 ± 140 ng/ml, p < 0.01) and biliary TIMP-1 concentrations were significantly lower (22.4 ± 4.9 vs. 29.4 ± 6.1 ng/ml, p < 0.01) in the malignant than in the benign group. In contrast, serum MMP-9 and TIMP-1 concentrations were similar in the two groups. Receiver operating curve analysis revealed that the areas under the curve of bile MMP-9 and TIMP-1 were significantly higher than 0.5 (p < 0.001). The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and accuracy were 0.94, 0.32, 0.36, 0.93, 1.40, 0.19 and 0.5 for biliary MMP-9, respectively, and 0.97, 0.36, 0.39, 0.97, 1.5, 0.08 and 0.54 for biliary TIMP-1, respectively. Conclusion: Serum and biliary MMP-9 and TIMP-1 tests do not appear to be useful in the diagnosis of cholangiocarcinoma.
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    The Role of EUS Examination and EUS-Guided Fine Needle Aspiration Biopsy for Evaluation of Gastric Subepithelial Lesions: a Large Single Center Experience
    (2015-05-01) BAYSAL, Birol; MASRI, Omar; DANALIOGLU, Ahmet; ILBAK, Ayca; KAYAR, Yusuf; Ince, ALİ TÜZÜN; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
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    PublicationOpen Access
    Staging of rectal carcinoma: MDCT, MRI or EUS. Single center experience
    (2014-12-01) KOCAMAN, Orhan; BAYSAL, Birol; Senturk, HAKAN; Ince, ALİ TÜZÜN; MUSLUMANOGLU, Mahmut; KOCAKOC, Ercan; ARICI, Sema; Uysal, Omer; YILDIZ, Kemal; TURKDOGAN, Kursat; DANALIOGLU, Ahmet; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜN; UYSAL, ÖMER
    Background/Aims: To retrospectively compare the efficacy of multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) and endosonography (EUS) in the staging of rectal carcinoma. Materials and Methods: A total of 50 patients (36 male, 14 female) were included in the study. The data from surgical staging were used as reference for comparing the yield of EUS, MRI, and MDCT in preoperative T and N staging of rectal carcinoma. Comparisons were based on the chi-square test. Results: The mean age+SD of the patients were 60±12 years (range; 28-80). The distribution of rectal tumors according to the T and N staging in surgical pathology was as following: T1 (n:2), T2 (n:15), T3 (n:22), T4 (n:11); N0 (n:22), N1-2 (n:28). The accuracy rate of EUS was statistically higher than that of MDCT (92% vs 64%; p<0.01) and that of MRI (92% vs 72%; p<0.01) for T2 tumors. For T3 tumors, EUS had statistically better accuracy of staging compared to MDCT (90% vs 58%; p<0.01) and MRI (90% vs 60%; p<0.01). As for T4 tumors, the accuracy rate of EUS was higher compared to MRI (98% vs 80%; p<0.01). There was no statistical difference in accuracy rates for detection of lymph nodes across the modalities (EUS, 84%; MDCT 76%; MRI 70%; p=not significant). Conclusion: EUS appears more accurate in T staging compared to MDCT and MRI in rectal carcinoma. Regarding nodal staging, performance of EUS, MDCT and MRI are similar.
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    Endoscopic stapling in comparison to laparoscopic fundoplication for the treatment of gastroesophageal reflux disease
    (2014-01-01) DANALIOGLU, Ahmet; CIPE, Gokhan; TOYDEMIR, Toygar; KOCAMAN, Orhan; Ince, ALİ TÜZÜN; MUSLUMANOGLU, Mahmut; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
    BackgroundThe SRSTM Endoscopic Stapling System (Medigus Ltd, Omer, Israel) is a novel method for the treatment of gastroesophageal reflux disease (GERD). The present study assessed the safety and efficacy of SRS compared with laparoscopic anti-reflux surgery (LARS).