Person:
AKYÜZ, ENES

Profile Picture
Status
Kurumdan Ayrılmıştır
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
ENES
Last Name
AKYÜZ
Name
Email Address
Birth Date

Filters

2017 - 20183
Reset filters

Settings

Author: MEGA TİBER, PINAR ×

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    Accumulation of cardiac inwardly rectifier potassium channels in a rat model of epilepsy
    (2017-07-01) AKYÜZ, ENES; MEGA TİBER, PINAR; ERCAN, ÇİLEM; AKBAŞ, FAHRİ; AKYÜZ, ENES; ERCAN, ÇİLEM; AKBAŞ, FAHRİ
  • No Thumbnail Available
    PublicationMetadata only
    Change of ST segment in ECG recording and its relation with potassium channels in experimental epilepsy model induced in rats
    (2017-03-03) AKYÜZ, ENES; MEGA TİBER, PINAR; YEŞİL, GÖZDE; AKYÜZ, ENES; YEŞİL, GÖZDE
  • Thumbnail Image
    PublicationOpen Access
    Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats
    (2018-12-01) MEGA TİBER, PINAR; AKYÜZ, ENES; KARAKAŞ, MERVE; AKBAŞ, FAHRİ; AKYÜZ, ENES; BEKER, MERVE; AKBAŞ, FAHRİ
    Clinical and experimental studies show that epilepsy affects cardiac function; however, the underlying molecular mechanism has not been fully elucidated. Inwardly-rectifying potassium (Kir) channels transport K+ ions into excitable cells such as neurons and cardiomyocytes; they control the cell excitability by acting towards the repolarization phase of cardiac action potential. Kir channel expression has been previously shown to vary in epileptic brains, at the same time seizures are known to affect the autonomic nervous system. Kir channel expression in cardiac tissue is a possible mechanism for the explanation of cardiac pathology in epilepsy. We investigate the expression of Kir channels in epileptic cardiac tissue by using pentylenetetrazole (PTZ)-kindling model in rats. Our molecular analyses showed significant decrease in cardiac Kir channel mRNA and protein expression of PTZ-kindled rats. Interestingly, both Kir2.x, which directs I-K1 flux in ventricular tissue and Kir3.x, which is responsible for I-KACh in the atria, were observed to decrease significantly. Kir channel expression also differs between females and males. This is the first study to our knowledge in epileptic cardiac tissue showing the expression of Kir channels. Our results show that Kir channels may play a role in cardiac pathology associated with epilepsy.