Person: GÜLER, ERAY METİN
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Publication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-08-01) GUNES-BAYIR, Ayse; Kiziltan, HURİYE ŞENAY; Guler, ERAY METİN; KARAKAS, Ersin; Kocyigit, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only An Optimum Dose of Olive Leaf ExtractImproves Insulin Receptor Substrate-1,Tyrosine Kinase, and Glucose Transporters,While High Doses Have Genotoxic andApoptotic Effects(2019-11-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Kasap, Burçin; GÜLER, ERAY METİN; Kaleli, Hümeyra Nur; Kesmen, Mustafa; DİKİLİTAŞ, MURAT; Karataş, Ersin; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Evaluation of xenon, light-emitting diode (LED) and halogen light toxicity on cultured retinal pigment epithelial cells(2018-11-01) SEZER, TAHA; ALTINIŞIK, MUHAMMED; GÜLER, ERAY METİN; Kocyigit, Abdurrahim; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİF; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİFObjective: To compare the possible toxic effects of three light sources used in vitreoretinal endoillumination systems; halogen, xenon, and light-emitting diode (LED) on retinal pigment epithelium (RPE) cell cultures, after two different exposure times. Material and methods: ARPE-19 human RPE cell cultures were exposed to halogen, xenon, and LED light sources at a distance of 1.5 cm for 30 and 60 min with equal lumen output levels. Cells in the control group were not exposed. RPE cell cultures were compared in terms of cell viability, DNA damage, apoptosis rate, and IL-1 ss, IL-6, and TNF- alpha levels. Results: The halogen light group showed significantly more DNA damage, higher TNF-alpha, IL-1 beta, and IL-6 levels, and lower viable cell count at 30 min compared to the control group. The rates of early and late apoptosis were also significantly higher at 60 min. There were no statistically significant differences in any of the parameters between the xenon and LED light sources and the control group at 30 or 60 min. Conclusion: New generation lights, xenon, and LED, seem to be safe in terms of RPE cells. Halogen light may cause toxic effects on RPE cells when used for a long time with maximal power output.Publication Metadata only Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3(2019-01-01) HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; Akdur, Kerime; Khan, Imran; Nalli, Arife; Karataş, Ersin; TÜZGEN, SAFFET; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KHAN, IMRANBACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.Publication Metadata only In vitro effects of two major phenolic compounds from the family Lamiaceae plants on the human gastric carcinoma cells(2018-08-01) GÜNES-BAYIR, Ayse; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Investigation of the effect of flavonoid nobiletin on TLR4 signaling pathway in prostate cancer cell lines(2019-07-01) DEVECİ, ASUMAN; KALELİ, SÜLEYMAN; ÖNEN, HACER İLKE; AKSOY, ÖMER; KALELİ, HANDAN NUR; GÜLER, ERAY METİN; KALAYCI YİĞİN, AYSEL; AKDOĞAN, MEHMET; GÜLER, ERAY METİNPublication Metadata only Dose-dependent proliferative and cytotoxic effects of melatonin on human epidermoid carcinoma and normal skin fibroblast cells(2018-05-01) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KARATAŞ, Ersin; CAGLAR, Hifa; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BULUT, HURIPublication Metadata only The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients.(2020-07-12T00:00:00Z) Koc, MM; Kocyigit, A; Yabaci, A; Guler, Eray Metin; Okay, G; Akkoyunlu, Y; OKAY, GÜLAY; MERİÇ KOÇ, MELİHA; GÜLER, ERAY METİN; YABACI TAK, AYŞEGÜL; KOÇYİĞİT, ABDÜRRAHİM; AKKOYUNLU, YASEMİNPublication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Treatment of Ulcerative Colitis Disease with Rosmarinus officinalis(2017-01-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; Bayındır, Nihan; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; TOPRAK, ALİ; GÜLER, ERAY METİN; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI