Person: GÜLER, ERAY METİN
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Publication Open Access Circulating levels of cytokines are increased in restless legs syndrome.(2020-10-21T00:00:00Z) Uslu, FI; Koçyiğit, A; Demir, E; Güler, Eray Metin; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMBackground: Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. In this study, we compared the circulating levels of hsCRP, IL-1β, IL-6, and TNF-α in patients with primary restless legs syndrome [RLS] and healthy control subjects. Methods: We prospectively included 29 patients with primary RLS and 65 healthy controls [HC], all age-sex matched. The diagnosis of RLS was established using international guidelines. IRLSSG Severity Scale was used to evaluate the severity of RLS. Plasma levels of hsCRP, IL-1β, IL-6, and TNF-α were measured in all participants. Results: The mean age of patients was 37.8 ± 11.3 and 52% of RLS group were women. Serum IL-1β, IL-6, and TNF-α levels of the patient group were statistically significantly higher compared to HC [p < 0.001 for all variables]. Plasma levels of hsCRP did not differ between groups. There were 8 patients with mild RLS [28%], 13 patients with moderate RLS [45%], and 8 patients with severe RLS [28%]. Only IL-6 values were significantly different between the groups. In the severe group, the value of IL-6 was significantly higher than in the other groups [p: 0.03]. Conclusion: These results showing higher circulating levels of inflammatory cytokines in patients with RLS support the notion that inflammation may be involved in the pathogenesis of primary RLS. However, it is necessary to perform further studies to determine if this finding is a cause or an effect.Publication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-08-01) GUNES-BAYIR, Ayse; Kiziltan, HURİYE ŞENAY; Guler, ERAY METİN; KARAKAS, Ersin; Kocyigit, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Serum obestatin and omentin levels in patients with diabetic nephropathy(2017-02-01) ZORLU, MEHMET; KISKAC, MUHARREM; Gueler, ERAY METİN; GUELTEPE, I.; YAVUZ, E.; CELIK, K.; KOCYIGIT, ABDÜRRAHİM; ZORLU, MEHMET; KISKAÇ, MUHARREM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMIntroduction: Diabetic nephropathy is the leading cause of chronic kidney disease and accounts for almost 45% of all new patients requiring renal replacement therapy. Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. Thus, we postulated that they may also have an association with diabetic nephropathy which is known to be an independent cardiovascular risk factor. In order to investigate such an association we compared serum omentin and obestatin levels in type 2 diabetic patients with normoalbuminuria (NA) and macroalbuminuria (MA). Materials and Methods: A total of 81 type 2 diabetic patients were separated into two groups according to their proteinuria status; patients with NA (n = 39) and patients with MA (n = 42). Two groups were compared in terms of serum omentin and obestatin levels. Results: While serum omentin levels did not differ among two groups (P = 0.407), serum obestatin levels were significantly higher in MA group (P = 0.001). Conclusion: The results of this study showed that higher serum levels of obestatin were associated with macro albuminuria suggesting that obestatin may have a role in underlying pathogenic mechanisms that leads to diabetic nephropathyPublication Metadata only An Optimum Dose of Olive Leaf ExtractImproves Insulin Receptor Substrate-1,Tyrosine Kinase, and Glucose Transporters,While High Doses Have Genotoxic andApoptotic Effects(2019-11-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Kasap, Burçin; GÜLER, ERAY METİN; Kaleli, Hümeyra Nur; Kesmen, Mustafa; DİKİLİTAŞ, MURAT; Karataş, Ersin; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Evaluation of xenon, light-emitting diode (LED) and halogen light toxicity on cultured retinal pigment epithelial cells(2018-11-01) SEZER, TAHA; ALTINIŞIK, MUHAMMED; GÜLER, ERAY METİN; Kocyigit, Abdurrahim; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİF; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİFObjective: To compare the possible toxic effects of three light sources used in vitreoretinal endoillumination systems; halogen, xenon, and light-emitting diode (LED) on retinal pigment epithelium (RPE) cell cultures, after two different exposure times. Material and methods: ARPE-19 human RPE cell cultures were exposed to halogen, xenon, and LED light sources at a distance of 1.5 cm for 30 and 60 min with equal lumen output levels. Cells in the control group were not exposed. RPE cell cultures were compared in terms of cell viability, DNA damage, apoptosis rate, and IL-1 ss, IL-6, and TNF- alpha levels. Results: The halogen light group showed significantly more DNA damage, higher TNF-alpha, IL-1 beta, and IL-6 levels, and lower viable cell count at 30 min compared to the control group. The rates of early and late apoptosis were also significantly higher at 60 min. There were no statistically significant differences in any of the parameters between the xenon and LED light sources and the control group at 30 or 60 min. Conclusion: New generation lights, xenon, and LED, seem to be safe in terms of RPE cells. Halogen light may cause toxic effects on RPE cells when used for a long time with maximal power output.Publication Metadata only Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3(2019-01-01) HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; Akdur, Kerime; Khan, Imran; Nalli, Arife; Karataş, Ersin; TÜZGEN, SAFFET; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KHAN, IMRANBACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.Publication Metadata only In vitro effects of two major phenolic compounds from the family Lamiaceae plants on the human gastric carcinoma cells(2018-08-01) GÜNES-BAYIR, Ayse; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Investigation of the effect of flavonoid nobiletin on TLR4 signaling pathway in prostate cancer cell lines(2019-07-01) DEVECİ, ASUMAN; KALELİ, SÜLEYMAN; ÖNEN, HACER İLKE; AKSOY, ÖMER; KALELİ, HANDAN NUR; GÜLER, ERAY METİN; KALAYCI YİĞİN, AYSEL; AKDOĞAN, MEHMET; GÜLER, ERAY METİNPublication Metadata only Dose-dependent proliferative and cytotoxic effects of melatonin on human epidermoid carcinoma and normal skin fibroblast cells(2018-05-01) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KARATAŞ, Ersin; CAGLAR, Hifa; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BULUT, HURIPublication Metadata only The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients.(2020-07-12T00:00:00Z) Koc, MM; Kocyigit, A; Yabaci, A; Guler, Eray Metin; Okay, G; Akkoyunlu, Y; OKAY, GÜLAY; MERİÇ KOÇ, MELİHA; GÜLER, ERAY METİN; YABACI TAK, AYŞEGÜL; KOÇYİĞİT, ABDÜRRAHİM; AKKOYUNLU, YASEMİN