Person: EMİROĞLU, NAZAN
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Publication Metadata only Dermoscopic and clinical features of pigmented skin lesions of the genital area.(2015-03-01T00:00:00Z) Cengiz, FATMA PELİN; EMIROGLU, NAZAN; WELLENHOF, RH; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANPublication Metadata only Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides(2015-01-01T00:00:00Z) Cengiz, FATMA PELİN; Emiroglu, NAZAN; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANBACKGROUND: Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, is more common in patients aged 45-55.Publication Open Access Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi(2017-02-01) Cengiz, FATMA PELİN; Emiroglu, NAZAN; OZKAYA, Dilek Biyik; Onsun, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEBackground: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Methods: A nonrandomized observational study was performed. A total of 108 melanocytic nevi were analysed by clinical and dermoscopic examination. Results: Of the subjects, 57.4% were aged less than 16 years, 42.6% were aged 16 and more. Of the nevi, 26 had reticular pattern (24.1%), 35 had globular pattern (32.4%), 13 had reticular-globular pattern (12.0%), 16 had homogeneous pattern (14.8%), 6 had reticular-homogeneous pattern (5.6%), 2 had globular-homogeneous pattern (1.9%), 7 had cobblestone pattern (6.5%), 3 had reticular patchy pattern (2.8%). Atypical dots and globules, focal hypopigmentation and perifollicular hypopigmentation are the most common dermoscopic features of CMN. The rarest dermoscopic feature is the blue-whitish veil. Conclusion: Most of the dermoscopic features related with dysplastic nevi up to the present, such as atypical dots and globules, focal hypopigmentation, perifollicular hypopigmentation were observed in CMN, in our study. Congenital nevus and dysplastic nevi may share the same dermoscopic features, therefore it is important to know it is found at birth or not.Publication Open Access Insulin resistance in severe acne vulgaris(2015-01-01T00:00:00Z) Emiroglu, NAZAN; Cengiz, FATMA PELİN; KEMERIZ, Funda; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINIntroduction: Acne vulgaris is a pilosebaceous gland disease that usually affects people from puberty to young adulthood. It is seen especially on the face, neck, trunk and arms. Its severity differs from patient to patient and its pathogenesis is multifactorial. The main pathogenic factors of acne are high sebaceous gland secretion, follicular hyperproliferation, high androgen effects, propionibacterium acnes colonization and inflammation. Diet is always thought a probable reason for acne and many studies are done about acne and diet.Publication Open Access The relation between dermoscopy and histopathology of basal cell carcinoma(2015-05-01) Emiroglu, NAZAN; Cengiz, FATMA PELİN; KEMERIZ, Funda; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN: Basal cell carcinoma is the most frequent cancer in fair-skinned populations and dermoscopy is an important, non-invasive technique that aids in the diagnosis of Basal cell carcinoma. OBJECTIVES: The aim of this study was to evaluate the relationship between histopathological subtypes and dermoscopic features of Basal cell carcinoma. METHODS: This study included 98 patients with clinically and histopathologically confi rmed Basal cell carcinomas. The dermoscopic features of the lesions from each patient were analyzed before the histopathological fi ndings were evaluated. RESULTS: Dermoscopic structures were observed in all 98 patients and irregular vascularity was identifi ed in 78 patients (79.6%). The most common vascular pattern was the presence of arborizing vessels (42 patients, 42.9%) followed by arborizing microvessels (21 patients, 21.4%) and short fi ne telangiectasias (SFTs; 15 patients, 15.3%). White streaks (38 patients, 38.8%), translucency (31 patients, 31.6%), a milky-pink to red background (42 patients, 42.9%), and erosion/ulceration (29 patients, 29.6%) were also observed. Pigmented islands were seen as blue-gray globules (7 patients, 7.1%) and blue-gray ovoid nests (42 patients, 42.9%). The pigment distribution pattern was maple leaf-like areas in 9 patients (9.2 %) and spoke wheel-like areas in 6 patients (6.1%). CONCLUSIONS: Basal cell carcinomas show a wide spectrum of dermoscopic features. Arborizing vessels were the most common dermoscopic fi ndings in Basal cell carcinomas, while superfi cial Basal cell carcinomas displayed mainly milky-pink to red areas, and arborizing microvessels. The most common dermoscopic features of pigmented types were islands of pigment (blue-gray globules, blue-gray ovoid nests). In conclusion, dermoscopy can be used as a valuable tool for the diagnosis of Basal cell carcinomas and prediction of their histopathological subtypes. Keywords: Carcinoma, basal cell; Dermoscopy; Neoplasms, basal cellPublication Open Access Dermatoscopic findings of pigmented purpuric dermatosis(2016-09-01) Su, Ozlem; OZKAYA, Dilek Biyik; Emiroglu, NAZAN; Cengiz, FATMA PELİN; Bahali, ANIL GÜLSEL; Yildiz, PELİN; DEMIRKESEN, Cuyan; Onsun, NAHİDE; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; CENGİZ, FATMA PELIN; BAHALI, ANIL GÜLSEL; YILDIZ, PELİN; ONSUN, NAHIDEackground:: Pigmented purpuric dermatosis is a chronic skin disorder of unknown aetiology characterised by symmetrical petechial and pigmented macules, often confined to the lower limbs. The aetiology of pigmented purpuric dermatosis is unknown. Dermatoscopy is a non-invasive diagnostic technique that allows the visualisation of morphological features invisible to the naked eye; it combines a method that renders the corneal layer of the skin translucent with an optical system that magnifies the image projected onto the retina. Objectives:: The aim of this study is to investigate the dermatoscopic findings of pigmented purpuric dermatosis. Methods:: This study enrolled patients diagnosed histopathologically with pigmented purpuric dermatosis who had dermatoscopic records. We reviewed the dermatoscopic images of PPD patients who attended the outpatient clinic in the Istanbul Dermatovenereology Department at the Bezmialem Vakıf University Medical Faculty. Results:: Dermatoscopy showed: coppery-red pigmentation (97%, n = 31) in the background, a brown network (34%, n = 11), linear vessels (22%, n = 7), round to oval red dots, globules, and patches (69%, n = 22; 75%, n = 24; 34%, n = 11; respectively), brown globules (26%, n = 8) and dots (53%, n = 17), linear brown lines (22%, n = 7), and follicular openings (13%, n = 4). Conclusion:: To our knowledge, this is the first study to report the dermatoscopy of pigmented purpuric dermatosis. In our opinion, dermatoscopy can be useful in the diagnosis of pigmented purpuric dermatosis.Publication Open Access Evaluation of mean platelet volume in localized scleroderma(2017-09-01) Bahali, ANIL GÜLSEL; Su, Ozlem; Emiroglu, NAZAN; Cengiz, FATMA PELİN; Kaya, MEHMET ONUR; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; KAYA, MEHMET ONUR; ONSUN, NAHIDEAbstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. Objectives: To evaluate whether there was any relation between localized scleroderma and platelet parameters. Methods: Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. Results: The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01). Study Limitations: The limited number of patients and the retrospective nature of the study were our limitations. Conclusions: This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies. Keywords: Blood platelets; Scleroderma, localized; Transforming growth factor betaPublication Open Access Dermoscopic and clinical features of head and neck melanoma(2015-07-01) Cengiz, FATMA PELİN; CENGIZ, Abdurrahman Bugra; Emiroglu, NAZAN; COMERT, Ela; WELLENHOF, Rainer Hofmann; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANAbstract: BACKGROUND: The dermoscopic criteria of extrafacial melanomas are well-known. OBJECTIVE: To determine the frequency of dermatoscopic fi ndings in head and neck melanomas (HNM) and to assess the distinguishing dermoscopic criteria of facial and extrafacial melanoma. METHODS: This observational study included 108 patients with HNM (63% male, mean age 64 years). Participants underwent individual dermoscopic imaging of clinically melanoma. All lesions were excised, and histopathological examination was performed on all specimens. RESULTS: Drawing on histopathological analysis, lentigo maligna melanoma or lentigo maligna was diagnosed in 60 lesions, superfi cial spreading melanoma in 18, nodular in 10, desmoplastic in 8, superfi cial spreading melanoma in situ in 12. The most frequent location for head and neck melanoma was the cheek (60 patients, 55.6%). Eight prominent dermatoscopic features were observed in facial melanoma: annular-granular pattern (18%); rhomboidal structures (29%); pseudonetwork (29%); asymmetrical, pigmented, follicular openings (51%); obliterated hair follicles (8%); red rhomboidal structures (18%); increased density of the vascular network (32%); scar-like depigmentation (59%). CONCLUSIONS: HNM has specifi c dermoscopic features, and classical extrafacial dermoscopic rules are less useful for diagnosis of facial melanoma. In our study, further characteristic dermatoscopic fi ndings were detected in facial melanoma such as low frequencies of irregular dots, 2 or fewer colors in lesions, the presence of pseudonetwork, increased density of the vascular network, red rhomboidal structures, in addition to dermatoscopic fi ndings of extrafacial melanoma. Thus, it is concluded that the prediction and identifi cation of HNM may be evident with the help of these signsPublication Metadata only Serum IL-17A in Behcet-s disease(2015-01-01T00:00:00Z) Emiroglu, NAZAN; Cengiz, FATMA PELİN; ERDEM, Gul Bahar; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINIntroduction: Behcet-s disease is a chronic multisystem disease with spontaneous remissions and relapses. Several studies show that autoimmune mechanisms play an important role in the development of Behcet-s disease. Activation of T cells and neutrophils is important in the pathogenesis of the disease. Interleukin 17 (IL-17) is a new cytokine that induces several types of cells to secrete proinflammatory cytokines in many inflammatory and autoimmune diseases.