Person: EMİROĞLU, NAZAN
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Publication Metadata only Serum visfatin levels in Behcet-s disease(2015-01-01T00:00:00Z) EMİROĞLU, Nazan; CENGİZ, Fatma Pelin; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINBackground and Design: The genetic predisposition, infectious agents, various antibodies and oxidative stress has been suggested to be among the possible causes of the etiopathogenesis of Behcet-s disease (BD). Recently, a new protein called visfatin, synthesized by adipose tissue has been identified. Visfatin has been found to be associated with many cases like insulin resistance, obesity, atherosclerosis, inflammation, immunity. In this study, we aimed to evaluate the relationship between serum visfatin levels and the activity of Behcet-s disease, and determine the role of visfatin in the inflammatory process of BD.Publication Metadata only Dermoscopic and clinical features of pigmented skin lesions of the genital area.(2015-03-01T00:00:00Z) Cengiz, FATMA PELİN; EMIROGLU, NAZAN; WELLENHOF, RH; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANPublication Open Access Evaluation of Neopterin Level and Disease Severity in Patients with Psoriasis Vulgaris Treated with Narrowband UVB.(2019-11-01T00:00:00Z) Kemeriz, F; Cengiz, FP; Gönül, M; Emiroğlu, Nazan; Cemil, BÇ; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANBackground: Neopterin is a biochemical marker of cellular immunity. It has been reported that serum and urine neopterin levels increase in psoriasis and decrease with treatment. Nevertheless, assessment of a direct link between narrowband ultraviolet B (UVB) therapy and neopterin level in association with Psoriasis Area and Severity Index (PASI) scores has not been performed yet. We aimed to evaluate the serum neopterin level in patients with psoriasis treated with narrowband UVB therapy in association with disease severity. Materials and methods: The study included 35 patients with chronic plaque-type psoriasis who had PASI scores of >10 or below 10 but resistant to topical therapies and 30 healthy individuals. The narrowband UVB therapy was administered to the patient group (n = 35). Serum neopterin analysis was performed with an enzyme-linked immunosorbent assay method before and after treatment. Results: There was statistically significant correlation between neopterin level and PASI score in the patient group (P = 0.011). The serum neopterin level was significantly increased in patients with higher PASI score. Moreover, the serum neopterin level was found to be statistically higher in severe psoriasis group (PASI score ≥10, n = 14) than the mild-moderate group (PASI score <10, n = 21) (P = 0.001). Furthermore, a significant decrease was observed according to serum neopterin level after the narrowband UVB therapy in the remaining 20 patients who were able to comply with the scheduled therapy and follow-up procedure (P = 0.026). Conclusion: Serum neopterin levels were found to be an useful marker for evaluating disease severity and efficacy of narrowband UVB treatment. Thus, our findings may provide a new approach with the management of disease and follow-up strategies in patients with psoriasis.Publication Metadata only A case of lichen aureus treated with tacrolimus Takrolimusla tedavi edilen bir liken aureus olgusu(2014-01-01T00:00:00Z) Emiroǧlu, NAZAN; Cengiz, FATMA PELİN; KEMERIZ, Funda; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINPublication Metadata only Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides(2015-01-01T00:00:00Z) Cengiz, FATMA PELİN; Emiroglu, NAZAN; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANBACKGROUND: Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, is more common in patients aged 45-55.Publication Open Access Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi(2017-02-01) Cengiz, FATMA PELİN; Emiroglu, NAZAN; OZKAYA, Dilek Biyik; Onsun, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEBackground: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Methods: A nonrandomized observational study was performed. A total of 108 melanocytic nevi were analysed by clinical and dermoscopic examination. Results: Of the subjects, 57.4% were aged less than 16 years, 42.6% were aged 16 and more. Of the nevi, 26 had reticular pattern (24.1%), 35 had globular pattern (32.4%), 13 had reticular-globular pattern (12.0%), 16 had homogeneous pattern (14.8%), 6 had reticular-homogeneous pattern (5.6%), 2 had globular-homogeneous pattern (1.9%), 7 had cobblestone pattern (6.5%), 3 had reticular patchy pattern (2.8%). Atypical dots and globules, focal hypopigmentation and perifollicular hypopigmentation are the most common dermoscopic features of CMN. The rarest dermoscopic feature is the blue-whitish veil. Conclusion: Most of the dermoscopic features related with dysplastic nevi up to the present, such as atypical dots and globules, focal hypopigmentation, perifollicular hypopigmentation were observed in CMN, in our study. Congenital nevus and dysplastic nevi may share the same dermoscopic features, therefore it is important to know it is found at birth or not.Publication Metadata only Dermatology residents- opinions: Problems and proposals of their solutions in residency training Deri ve zührevi hastaliklari uzmanlik ögrencilerinin görüsleri: Uzmanlik egitiminde sorunlar ve çözüm önerileri(2014-01-01T00:00:00Z) Cengiz, FATMA PELİN; KEMERIZ, Funda; Emiroǧlu, NAZAN; MEYDAN, Mustafa Caner; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANPublication Open Access Insulin resistance in severe acne vulgaris(2015-01-01T00:00:00Z) Emiroglu, NAZAN; Cengiz, FATMA PELİN; KEMERIZ, Funda; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINIntroduction: Acne vulgaris is a pilosebaceous gland disease that usually affects people from puberty to young adulthood. It is seen especially on the face, neck, trunk and arms. Its severity differs from patient to patient and its pathogenesis is multifactorial. The main pathogenic factors of acne are high sebaceous gland secretion, follicular hyperproliferation, high androgen effects, propionibacterium acnes colonization and inflammation. Diet is always thought a probable reason for acne and many studies are done about acne and diet.Publication Open Access The relation between dermoscopy and histopathology of basal cell carcinoma(2015-05-01) Emiroglu, NAZAN; Cengiz, FATMA PELİN; KEMERIZ, Funda; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN: Basal cell carcinoma is the most frequent cancer in fair-skinned populations and dermoscopy is an important, non-invasive technique that aids in the diagnosis of Basal cell carcinoma. OBJECTIVES: The aim of this study was to evaluate the relationship between histopathological subtypes and dermoscopic features of Basal cell carcinoma. METHODS: This study included 98 patients with clinically and histopathologically confi rmed Basal cell carcinomas. The dermoscopic features of the lesions from each patient were analyzed before the histopathological fi ndings were evaluated. RESULTS: Dermoscopic structures were observed in all 98 patients and irregular vascularity was identifi ed in 78 patients (79.6%). The most common vascular pattern was the presence of arborizing vessels (42 patients, 42.9%) followed by arborizing microvessels (21 patients, 21.4%) and short fi ne telangiectasias (SFTs; 15 patients, 15.3%). White streaks (38 patients, 38.8%), translucency (31 patients, 31.6%), a milky-pink to red background (42 patients, 42.9%), and erosion/ulceration (29 patients, 29.6%) were also observed. Pigmented islands were seen as blue-gray globules (7 patients, 7.1%) and blue-gray ovoid nests (42 patients, 42.9%). The pigment distribution pattern was maple leaf-like areas in 9 patients (9.2 %) and spoke wheel-like areas in 6 patients (6.1%). CONCLUSIONS: Basal cell carcinomas show a wide spectrum of dermoscopic features. Arborizing vessels were the most common dermoscopic fi ndings in Basal cell carcinomas, while superfi cial Basal cell carcinomas displayed mainly milky-pink to red areas, and arborizing microvessels. The most common dermoscopic features of pigmented types were islands of pigment (blue-gray globules, blue-gray ovoid nests). In conclusion, dermoscopy can be used as a valuable tool for the diagnosis of Basal cell carcinomas and prediction of their histopathological subtypes. Keywords: Carcinoma, basal cell; Dermoscopy; Neoplasms, basal cellPublication Open Access Frequency and risk factors for secondary malignancies in patients with mycosis fungoides(2016-08-01) EMIROGLU, NAZAN; CENGIZ, F. P.; BAHALI, A. Gulsel; Su, O.; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEMycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), has an incidence of 6.4 per million people [1]. Patients with CTCL have an increased risk of the development of secondary malignancies, particularly lymphomas [2,3]. We conducted a 20-year population-based cohort study to assess the risk factors of secondary cancers in MF patients from our center.