Person: SÜMBÜL, BİLGE
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Publication Open Access Temporal trends and patterns in antimicrobial-resistant Gram-negative bacteria implicated in intensive care unit-acquired infections: A cohort-based surveillance study in Istanbul, Turkey(2018-09-01) GULTEPE, Bilge; Kritsotakis, Evangelos; Lee, Andrew C. K.; Torun, PERİHAN; Hakyemez, Ismail N.; Aslan, Turan; DURDU, BÜLENT; TORUN, PERİHAN; SÜMBÜL, BİLGEObjectives: This study assessed trends and patterns in antimicrobial-resistant intensive care unit (ICU)-acquired infections caused by Gram-negative bacteria (GNB) in Istanbul, Turkey.Publication Metadata only Bezmialem Vakıf üniversitesi Tıp Fakültesi Hastanesi’nde influenza tanısı alan hastaların özellikleri(2016-05-15T00:00:00Z) KASAR, NURAY; DURDU, BÜLENT; SÜMBÜL, BİLGE; BOLUKCU, SİBEL; OKAY, GÜLAY; HAKYEMEZ, İSMAİL NECATİ; ASLAN, TURAN; DURDU, BÜLENT; SÜMBÜL, BİLGEPublication Metadata only Solunum Yolu Enfeksiyonu Etkeni Olarak İzole Edilen Haemophilus influenzae ve Moraxella catarrhalis-in Mevsimlere Göre Dağılımı(2017-03-19) GÜLTEPE, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; OKAY, GÜLAY; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZIYAPublication Metadata only Infective endocarditis case due to streptococcus parasanguinis presented with spondylodiscitis(2016-01-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; Okay, GÜLAY; GULTEPE, Bilge; Bolukcu, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; OKAY, GÜLAY; BOLUKÇU, SİBEL; SÜMBÜL, BİLGEStreptococcus parasanguinis is a natural member of oral flora. It is an opportunistic pathogen, and rarely cause systemic infections due to it-s low virulence. Subacute infective endocarditis may present with various clinical manifestations (eg., spondylodiscitis). A sixty-five years old male patient from Northern Iraq has referred to our emergency service with high fever, weight loss, back pain and inability to walk. The patient was a veterinarian. He was operated three years ago for colonic carcinoma and irradiated. In magnetic resonance imaging, spondylodiscitis was detected localized in lumbar 1-2 region. Transthorasic echocardiography demonstrated aortic valve vegetation. S. parasanguinis was identified in the blood cultures. In conclusion; all in all, it-s remarkable to isolate S. parasanguinis as a causal agent of infective endocarditis in a patient who is a veterinarian with history of colonic carcinoma presented with clinical manifestation of spondylodiscitis.Publication Metadata only <i>Clostridium difficile</i> infection: Is there a change in the underlying factors? Inflammatory bowel disease and <i>Clostridium difficile</i>.(2019-11-01T00:00:00Z) Durdu, B; Bolukcu, S; Okay, G; Hakyemez, IN; Gultepe, BİLGE; Koc, MELİHA; Aslan, T; SÜMBÜL, BİLGE; OKAY, GÜLAY; DURDU, BÜLENT; MERİÇ KOÇ, MELİHAPublication Metadata only Bir Üniversite Hastanesine Ayaktan Başvuran >=65 Yaşındaki Yüz Yetmiş Dört Hastanın Değerlendirmesi(2017-04-04T00:00:00Z) BOLUKÇU, SİBEL; OKAY, GÜLAY; SÜMBÜL, BİLGE; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; ASLAN, TURAN; SÜMBÜL, BİLGE; DURDU, BÜLENT; AKKOYUNLU, YASEMİNPublication Metadata only Nadir bir protez eklem enfeksiyonu etkeni: Salmonella paratyphi b.(2017-03-12T00:00:00Z) OKAY, GÜLAY; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; BOLUKCU, SİBEL; SÜMBÜL, BİLGE; ASLAN, TURAN; OKAY, GÜLAY; DURDU, BÜLENT; SÜMBÜL, BİLGEPublication Metadata only SALMONELLA ENTERİDİS’E BAĞLI NADİR BİR AMPİYEM OLGUSU(2015-04-01) Kurt Çınar, Ayşe Ruhkar; Bolukçu, Sibel; SÜMBÜL, BİLGE; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; ASLAN, TURAN; SÜMBÜL, BİLGE; DURDU, BÜLENTPublication Open Access Risk Factors Affecting Patterns of Antibiotic Resistance and Treatment Efficacy in Extreme Drug Resistance in Intensive Care Unit-Acquired Klebsiella Pneumoniae Infections: A 5-Year Analysis(2019-01-07) KOC, Meliha Meric; Durdu, BÜLENT; HAKYEMEZ, Ismail N.; Akkoyunlu, YASEMİN; Daskaya, HAYRETTİN; Gultepe, BİLGE; ASLAN, Turan; DURDU, BÜLENT; MERİÇ KOÇ, MELİHA; AKKOYUNLU, YASEMİN; DAŞKAYA, HAYRETTİN; SÜMBÜL, BİLGEBACKGROUND: We investigated the factors affecting antibiotic resistance in the intensive care unit (ICU)-related hospital-acquired infections caused by Klebsiella pneumoniae (KP-HAI) and the effects of antibiotics used for high-level antibiotic resistance on patient survival. MATERIAL AND METHODS: This retrospective study was performed at the adult ICU of Bezmialem Vakif University Hospital. Patients who were followed up between 01 January 2012 and 31 May 2017 were evaluated. Each KP strain was categorized according to resistance patterns and analyzed. The efficiency of antibiotic therapy for highly-resistant KP-HAI was determined by patients’ lifespans. RESULTS: We evaluated 208 patients. With the prior use of carbapenem, antibiotics against resistant Gram-positives, and tigecycline, it was observed that the resistance rate of the infectious agents had a significant increase. As the resistance category increases, a significant decrease was seen in the survival time. We observed that if the treatment combination included trimethoprim-sulfamethoxazole, the survival time became significantly longer, and tigecycline-carbapenem-colistin and tigecycline-carbapenem combination patients showed significantly shorter survival times. CONCLUSIONS: When the resistance increases, delays will occur in starting suitable and effective antibiotic treatment, with increased sepsis frequency and higher mortality rates. Trimethoprim-sulfamethoxazole can be an efficient alternative to extend survival time in trimethoprim-sulfamethoxazole-susceptible KP infections that have extensive drug resistance.Publication Metadata only Streptococcus parasanguinis’in neden olduğu spondilodiskit ile ortaya çıkan infektif endokardit olgusu(2016-09-01T00:00:00Z) DURDU, BÜLENT; SÜMBÜL, BİLGE; BOLUKCU, SİBEL; OKAY, GÜLAY; HAKYEMEZ, İSMAİL NECATİ; ASLAN, TURAN; DURDU, BÜLENT; OKAY, GÜLAY; SÜMBÜL, BİLGE