Person: DAĞ, AYDAN
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Publication Metadata only Synthesis of New Oleanane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines(2019-12-19) Dağ, Aydan; Topçu, Gülaçtı; Atasoy, Sezen; Aktaş, Asude Sena; Şenol, Halil; ŞENOL, HALIL; DAĞ, AYDAN; ATASOY, SEZEN; TOPÇU, GÜLAÇTIPublication Metadata only Sythesis of Glycopeptide Nanoparticles and Investigation of Their Efficacy in Cancer Therapy(2017-10-02) Dağ, Aydan; DAĞ, AYDAN; ATASOY, SEZENPublication Metadata only Targeting cancerous cell lines with glycopolymer micelles(2014-08-10) Dag, AYDAN; BABIUCH, Krzysztof; STENZEL, Martina; DAĞ, AYDANPublication Metadata only Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives(2017-02-15) KURT, Belma Zengin; Gazioglu, IŞIL; Dag, AYDAN; Salmas, Ramin Ekhteiari; Kayik, Gulru; Durdagi, Serdar; Sonmez, Fatih; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; DAĞ, AYDANNew thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was found to be the most potent AChE inhibitor with IC50 values of 2.22 mu M, and 5-isopropyl-2-methylphenyl (4-fluorophenyl)carbamate (30) exhibited the strongest inhibition against BuChE with IC50 value of 0.02 mu M. Additionally, the result of H4IIE hepatoma cell toxicity assay for compounds 18, 20, 29, 30 and 35 showed negligible cell death at 0.07-10 mu M. Moreover in order to better understand the inhibitory profiles of these molecules, molecular modeling studies were applied. Binding poses of studied compounds at the binding pockets of AChE and BuChE targets were determined. Predicted binding energies of these compounds as well as structural and dynamical profiles of molecules at the target sites were estimated using induced fit docking (IFD) algorithms and post-processing molecular dynamics (MD) simulations methods (i.e., Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) approaches). (C) 2016 Elsevier Ltd. All rights reserved.Publication Open Access Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine(2014-01-01T00:00:00Z) Bahadori, Fatemeh; Dag, Aydan; Durmaz, Hakan; Cakir, Nese; ONYUKSEL, Hayat; Tunca, Ümit; Topcu, Gulacti; Hızal, Gürkan; BAHADORİ, FATEMEH; DAĞ, AYDAN; TOPÇU, GÜLAÇTITwo amphiphilic block copolymers using hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)(4) type star polymer [(PCL-b-PEG)(4)] and the other one is a Y-shaped PEG-(PCL)(2). A star-shaped polymer (PCL-b-PEG)(4) was prepared by ring-opening polymerization (ROP) of epsilon-caprolactone continued by click reaction of (PCL-azide)(4) and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL)(2) block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of epsilon-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.Publication Metadata only Block-Brush Copolymers via ROMP and Sequential Double Click Reaction Strategy(2011-02-15T00:00:00Z) Dag, Aydan; Sahin, Hatice; Durmaz, Hakan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDANWe report an efficient way, sequential double click reactions, for the preparation of brush copolymers with AB black-brush architectures containing polyoxanorbornene (poly (ONB)) backbone and poly(epsilon-caprolactone) (PCL), poly(methyl methacrylate) (PMMA) or poly(tert-butyl acrylate) (PtBA) side poly(ONB-g-PMMA)-b-poly(ONB-g-PCL) and poly(ONB-g-F tBA)-b-poly(ONB-g-PCL). The living ROMP of ONB affords the synthesis of well-defined poly(ONB-anthracene)(20)-b-Poly (ONB-azide)(5) block copolymer with anthryl and azide pendant groups. Subsequently, well-defined linear alkyne end-functionalized PCL (PCL-alkyne), maleimide end-functionalized PMMA (PMMA-MI) and Pt8A-MI were introduced onto the block copolymer via sequential azide-alkyne and Diels-Alder click reactions, thus yielding block-brush copolymers. The molecular weight of block-brush copolymers was measured via triple detection GPC (TD-GPC) introducing the experimentally calculated dn/dc values to the software. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 886-892, 2011Publication Metadata only Graft Copolymers via ROMP and Diels-Alder Click Reaction Strategy(2010-12-15T00:00:00Z) Durmaz, Hakan; Dag, Aydan; Cerit, Nese; Sirkecioğlu, Okan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDANAnthracene functionalized oxanorbornene monomer and oxanorbornenyl polystyrene (PS) with omega anthracene end functionalized macromonomer were first polymerized via ring opening metathesis polymerization using the first generation Grubbs catalyst in dichloromethane at room temperature and then clicked with maleimide end functionalized polymers poly(ethylene glycol) (PEG) MI poly(methyl methacrylate) (PMMA) MI and poly(tert butyl acrylate) (PtBA) MI in a Diels-Alder reaction in toluene at 120 degrees C to create corresponding graft copolymers poly(oxanorbornene) g PEG poly(oxanorbor nene) g PMMA and graft block copolymers poly(oxanorbor nene) g (PS b-PEG) poly(oxanorbornene) g (PS b-PMMA) and poly(oxanorbornene) g (PS b-PtBA) respectively Diels-Alder click reaction efficiency for graft copolymerization was moni tored by UV-vis spectroscopy The dn/dc values of graft copolymers and graft block copolymers were experimentally obtained using a triple detection gel permeation chromatogra phy and subsequently introduced to the software so as to give molecular weights intrinsic viscosity ([eta]) and hydrodynamic radius (R-h) values (C) 2010 Wiley Periodicals Inc J Polym Sci Part A Polym Chem 48 5982-5991 2010Publication Metadata only Hedefli Upconversion Lüminesans Biyonanoprobların Hazırlanması ve Teranöstik Uygulamaları(2019-12-10T00:00:00Z) Dağ, Aydan; Yiğit, Gülşah; Omurtag Özgen, Pınar Sinem; Atasoy, Sezen; Gürek, Ayşe Gül; DAĞ, AYDANPublication Metadata only Investıgation Of Cytotoxic Activity of Vinorelbine Loaded Polymeric Micelles(2012-06-29) BAHADORİ, FATEMEH; DAĞ, AYDAN; HIZAL, GURKAN; TOPÇU, GÜLAÇTI; DURMAZ, HAKAN; ONYUKSEL, HAYAT; TUNCA, UMIT; BAHADORİ, FATEMEH; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Open Access Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors(2017-01-01) Sonmez, Fatih; KURT, Belma Zengin; Gazioglu, IŞIL; BASILE, Livia; Dag, AYDAN; CAPPELLO, Valentina; GINEX, Tiziana; Kucukislamoglu, Mustafa; GUCCIONE, Salvatore; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; DAĞ, AYDANNew coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide (6c, IC50 value of 43 nM) was the best AChE inhibitor with a selectivity index of 4151.16 over BuChE. Kinetic study of AChE inhibition revealed that 6c was a mixed-type inhibitor. Moreover, the result of H4IIE hepatoma cell toxicity assay for 6c showed negligible cell death. Molecular docking studies were also carried out to clarify the inhibition mode of the more active compounds. Best pose of compound 6c is positioned into the active site with the coumarin ring wedged between the residues of the CAS and catalytic triad of AChE. In addition, the coumarin ring is anchored into the gorge of the enzyme by H-bond with Tyr130.