Person: DAĞ, AYDAN
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Publication Metadata only Synthesis of New Oleanane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines(2019-12-19) Dağ, Aydan; Topçu, Gülaçtı; Atasoy, Sezen; Aktaş, Asude Sena; Şenol, Halil; ŞENOL, HALIL; DAĞ, AYDAN; ATASOY, SEZEN; TOPÇU, GÜLAÇTIPublication Metadata only Sythesis of Glycopeptide Nanoparticles and Investigation of Their Efficacy in Cancer Therapy(2017-10-02) Dağ, Aydan; DAĞ, AYDAN; ATASOY, SEZENPublication Metadata only Targeting cancerous cell lines with glycopolymer micelles(2014-08-10) Dag, AYDAN; BABIUCH, Krzysztof; STENZEL, Martina; DAĞ, AYDANPublication Metadata only Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives(2017-02-15) KURT, Belma Zengin; Gazioglu, IŞIL; Dag, AYDAN; Salmas, Ramin Ekhteiari; Kayik, Gulru; Durdagi, Serdar; Sonmez, Fatih; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; DAĞ, AYDANNew thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was found to be the most potent AChE inhibitor with IC50 values of 2.22 mu M, and 5-isopropyl-2-methylphenyl (4-fluorophenyl)carbamate (30) exhibited the strongest inhibition against BuChE with IC50 value of 0.02 mu M. Additionally, the result of H4IIE hepatoma cell toxicity assay for compounds 18, 20, 29, 30 and 35 showed negligible cell death at 0.07-10 mu M. Moreover in order to better understand the inhibitory profiles of these molecules, molecular modeling studies were applied. Binding poses of studied compounds at the binding pockets of AChE and BuChE targets were determined. Predicted binding energies of these compounds as well as structural and dynamical profiles of molecules at the target sites were estimated using induced fit docking (IFD) algorithms and post-processing molecular dynamics (MD) simulations methods (i.e., Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) approaches). (C) 2016 Elsevier Ltd. All rights reserved.Publication Metadata only Block-Brush Copolymers via ROMP and Sequential Double Click Reaction Strategy(2011-02-15T00:00:00Z) Dag, Aydan; Sahin, Hatice; Durmaz, Hakan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDANWe report an efficient way, sequential double click reactions, for the preparation of brush copolymers with AB black-brush architectures containing polyoxanorbornene (poly (ONB)) backbone and poly(epsilon-caprolactone) (PCL), poly(methyl methacrylate) (PMMA) or poly(tert-butyl acrylate) (PtBA) side poly(ONB-g-PMMA)-b-poly(ONB-g-PCL) and poly(ONB-g-F tBA)-b-poly(ONB-g-PCL). The living ROMP of ONB affords the synthesis of well-defined poly(ONB-anthracene)(20)-b-Poly (ONB-azide)(5) block copolymer with anthryl and azide pendant groups. Subsequently, well-defined linear alkyne end-functionalized PCL (PCL-alkyne), maleimide end-functionalized PMMA (PMMA-MI) and Pt8A-MI were introduced onto the block copolymer via sequential azide-alkyne and Diels-Alder click reactions, thus yielding block-brush copolymers. The molecular weight of block-brush copolymers was measured via triple detection GPC (TD-GPC) introducing the experimentally calculated dn/dc values to the software. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 886-892, 2011Publication Metadata only Graft Copolymers via ROMP and Diels-Alder Click Reaction Strategy(2010-12-15T00:00:00Z) Durmaz, Hakan; Dag, Aydan; Cerit, Nese; Sirkecioğlu, Okan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDANAnthracene functionalized oxanorbornene monomer and oxanorbornenyl polystyrene (PS) with omega anthracene end functionalized macromonomer were first polymerized via ring opening metathesis polymerization using the first generation Grubbs catalyst in dichloromethane at room temperature and then clicked with maleimide end functionalized polymers poly(ethylene glycol) (PEG) MI poly(methyl methacrylate) (PMMA) MI and poly(tert butyl acrylate) (PtBA) MI in a Diels-Alder reaction in toluene at 120 degrees C to create corresponding graft copolymers poly(oxanorbornene) g PEG poly(oxanorbor nene) g PMMA and graft block copolymers poly(oxanorbor nene) g (PS b-PEG) poly(oxanorbornene) g (PS b-PMMA) and poly(oxanorbornene) g (PS b-PtBA) respectively Diels-Alder click reaction efficiency for graft copolymerization was moni tored by UV-vis spectroscopy The dn/dc values of graft copolymers and graft block copolymers were experimentally obtained using a triple detection gel permeation chromatogra phy and subsequently introduced to the software so as to give molecular weights intrinsic viscosity ([eta]) and hydrodynamic radius (R-h) values (C) 2010 Wiley Periodicals Inc J Polym Sci Part A Polym Chem 48 5982-5991 2010Publication Metadata only Hedefli Upconversion Lüminesans Biyonanoprobların Hazırlanması ve Teranöstik Uygulamaları(2019-12-10T00:00:00Z) Dağ, Aydan; Yiğit, Gülşah; Omurtag Özgen, Pınar Sinem; Atasoy, Sezen; Gürek, Ayşe Gül; DAĞ, AYDANPublication Metadata only Investıgation Of Cytotoxic Activity of Vinorelbine Loaded Polymeric Micelles(2012-06-29) BAHADORİ, FATEMEH; DAĞ, AYDAN; HIZAL, GURKAN; TOPÇU, GÜLAÇTI; DURMAZ, HAKAN; ONYUKSEL, HAYAT; TUNCA, UMIT; BAHADORİ, FATEMEH; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Cyclic Homo and Block Copolymers Through Sequential Double Click Reactions(2010-11-15T00:00:00Z) Durmaz, Hakan; Dag, Aydan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDANWell-defined linear alpha-anthracene-omega-maleimide functionalized polystyrene (l-Anth-PS-MI) and linear alpha-alkyne-omega-maleimide functionalized poly(tert-butyl acrylate) (l-alkyne-PtBA-MI) homopolymers, and linear alpha-anthracene-omega-maleimide functionalized PS-b-PtBA (l-Anth-PS-b-PtBA-MI) and linear alpha-anthracene-omega-maleimide functionalized PS-b-poly(epsilon-caprolactone) (PCL) (l-Anth-PS-b-PCL-MI) block copolymers were obtained via combination of atom transfer radical polymerization (ATRP)/ring opening polymerization (ROP) and azide-alkyne click reaction strategy. Subsequently, these linear homo and block copolymers were efficiently clicked via Diels-Alder reaction to give their corresponding cyclic homo and block copolymers at reflux temperature of toluene for 48 h under 7-4 x 10(-5) M conditions. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 5083-5091, 2010Publication Metadata only Polymer-Albumin Conjugate for the Facilitated Delivery of Macromolecular Platinum Drugs(2015-05-01) Dag, AYDAN; JIANG, Yanyan; ABD KARIM, Khairil Juhanni; HART-SMITH, Gene; SCARANO, Wei; STENZEL, Martina H.; DAĞ, AYDANThe delivery of macromolecular platinum drugs into cancerous cells is enhanced by conjugating the polymer to albumin. The monomers N-(2-hydroxypropyl)methacrylamide (HPMA) and Boc protected 1,3-diaminopropan-2-yl acrylate (Ac-DAP-Boc) are copolymerized in the presence of a furan protected maleimide functionalized reversible addition-fragmentation chain transfer (RAFT) agent. The resulting polymer with a composition of P(HPMA(14)-co-(Ac-DAP-Boc)(9)) and a molecular weight of M-n = 7600 g mol(-1) (D = 1.24) is used as a macromolecular ligand for the conjugation to the platinum drug. Thermogravimetric analysis reveals full conjugation. After deprotection of the maleimide functionality of the polymer, the reactive polymer is conjugated to albumin using the Cys34 functionality. The conjugation is monitored using size exclusion chromatography, MALDI-TOF (matrix assisted laser desorption ionization time-of-flight), and SDS Page (sodium dodecyl sulphate polyacrylamide gel electrophoresis). The polymer-albumin conjugates self-assemble in water into nanoparticles of sizes of around 80 nm thanks to the hydrophobic nature of the platinum drugs. The albumin coated nanoparticles are readily taken up by ovarian cancer cell lines and they show superior toxicity compared to a control sample without protein coating.