Person: İNAN, BEKİR
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Publication Metadata only Regional block anesthesia in a patient with factor V Leiden mutation and axillary artery occlusion.(2011-01-01T00:00:00Z) ERKALP, K; COMLEKCI, M; INAN, BEKİR; Basaranoglu, GÖKÇEN; OZDEMIR, HÜSEYİN; SAIDOGLU, L; İNAN, BEKİR; BAŞARANOĞLU, GÖKÇENPublication Open Access Aortic Dissection In Case with Chronic Kidney Disease(2017-10-01) Buyukaydin, BANU; Alay, Murat; Kazancioglu, RÜMEYZA; UGUR, Aycan; Tunc, MUHAMMED; TEKER, Melike Elif; Inan, BEKİR; ERKOC, Reha; BÜYÜKAYDIN, BANU; KAZANCIOĞLU, RÜMEYZA; TUNÇ, MUHAMMED; İNAN, BEKİRAortic disection is an urgent clinical problem that rapid diagnosis and appropriate treatment is life-saving. Hypertension is one of the major risk factors. In this paper, a 56 years old female patient with hypertension and renal failure was presented. In this case after clinical suspicion aortic dissection was diagnosed with imaging studies. Endovascular aortic repair was performed but after surgery, patient died because of possible hemorrhage complication.Publication Open Access Effects of ischemic preconditioning and iloprost on myocardial ischemia-reperfusion damage in rats(2013-01-01) Ay, YASİN; Kara, Ibrahim; Aydin, CEMALETTİN; TEKER, Melike Elif; Senol, Serkan; Inan, BEKİR; BASEL, Halil; Uysal, Omer; Zeybek, RAHMİ; AY, YASİN; AYDIN, CEMALETTİN; KAHRAMAN AY, NURAY; İNAN, BEKİR; UYSAL, ÖMER; ZEYBEK, RAHMİThis study investigates the effects of cardiac ischemic preconditioning and iloprost on reperfusion damage in rats with myocardial ischemia/reperfusion. 38 male Wistar Albino rats used in this study were divided into 5 groups. The control group (Group 1) (n=6), ischemia/reperfusion (IR) group (Group 2) (n=8), cardiac ischemic preconditioning (CIP) group (Group 3) (n=8), iloprost (ILO) group (Group 4) (n=8), and cardiac ischemic preconditioning + iloprost (CIP+ILO) group (Group 5) (n=8). Pre-ischemia, 15 minutes post-ischemia, 45 minutes post-reperfusion, mean blood pressure (MBP), and heart rates (HR) were recorded. The rate-pressure product (RPP) was calculated. Post-reperfusion plasma creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin (cTn) vlaues, and infarct size/area at risk (IS/AAR) were calculated from myocardial tissue samples. Arrhythmia and ST segment elevations were evaluated during the ischemia and reperfusion stages. Although the MBP, HR, RPP values, biochemical parameters of CK-MB and LDH levels, IS/AAR rates, ST segment elevation values were found to be similar in CIP and CIP+ILO groups and the IR and ILO groups (p>0.05), CIP-containing group values had a positively meaningful difference (p<0.05) compared with the IR and ILO group. While mild-moderate findings of damage were observed in Group 3 and Group 5, severely findings of damage were releaved in Group 2 and Group 4. The arrhythmia score of the ILO group was meaningfully lower (F: 41.4, p<0.001) than the IR group. We can conclude that the effects of myocardial reperfusion damage can be reduced by cardiac ischemic preconditioning, intravenous iloprost reduced the incidence of ventricular arrhythmia associated with reperfusion, and its use with CIP caused no additional changes.Publication Metadata only Effects of Cilostazol and Diltiazem Hydrochloride on Ischemia-Reperfusion Injury in a Rat Hindlimb Model.(2017-04-01) ERGÜN, SELMA; İNAN, BEKİR; ERGÜN, SELMA; ZİYADE, SEDATObjective: Free radicals and neutrophils are potent sources of ischemia-reperfusion injury (I/R) and they can be limited by the use of exogenous application of some therapeutic agents. The objective of this study was to compare the effects of cilostazol and diltiazem hydrochloride in a rat hind limb model of I/R injury.Publication Metadata only A giant right atrial villous myxoma with simultaneous pulmonary embolism(2014-01-01T00:00:00Z) AYDIN, CEMALETTİN; Tasal, Abdurrahman; Yasin, Ay; Vatankulu, Mehmet Akif; İNAN, BEKİR; BACAKSIZ, AHMET; AYDIN, CEMALETTİN; İNAN, BEKİR; BACAKSIZ, AHMETINTRODUCTION: Primary cardiac tumors are rare and approximately three quarters of them are benign and up to half of the benign tumors are myxomas. Right atrial villous myxoma with pulmonary embolism is an unusual apparition.Publication Open Access Straight versus S-shaped sternotomy: a histologic study in the sheep model(2014-10-01) KÜÇÜKDURMAZ, FATİH; İNAN, BEKİR; KÜÇÜKDURMAZ, FATİHIntroduction: Straight sternotomy is the most common access for open heart surgery. Techniques have been proposed for maximizing sternal stability in high-risk patients. This trend implies a growing need for newer surgical techniques. The aim of this experimental study in the sheep model is to evaluate median vs. S shaped sternotomy the feasibility of using a special device to accelerate the sternal instability and bone healing. Materials and methods: We enrolled 31 sheep, weighing 18–30 kg. For all animals a midline skin incision was made. In group I (n = 16 animals), straight median sternotomy and in group II (n = 15 animals), S-shaped incision was marked on the periosteum of the sternum by new created device for standard S-shaped sternotomy. Sternum biopsies were performed on second surgery month for all survived animals from the sternum and the surrounding soft tissue. Results: No early superficial wound complications were observed. Overall mortality in the initial approach group was 19.3% (6 sheep). In group I; 3 sheep had died on first surgery day, the reason may be hemorrhage and in group II; 3 sheep developed intractable VF during surgery procedure or immediately afterwards so died. There were statistically significant differences in the scores of bone healing between group 1 and group 2 (4.2 vs.7.3, ANOVA, p < 0.001). Discussion: Our work is based on the use of a standard S-shaped sternotomy procedure on sheep sternum. In our experience with the sternal healing in the sheep model, the process of new bone formation was accelerated with S- shaped cut than straight sternotomy procedurePublication Open Access Surgical treatment of lower limb ischemia in diabetic patients - long-term results(2013-12-01T00:00:00Z) İNAN, BEKİR; Aydin, Unal; Ugurlucan, Murat; AYDIN, CEMALETTİN; Teker, Melike Elif; İNAN, BEKİR; AYDIN, CEMALETTİNIntroduction: Lower limb ischemia may cause nonhealing ulcers, infection, amputation and even mortality in diabetic patients. In this study, we review our data of ischemic lower limb revascularization procedures in diabetic patients and present the early, mid- and long-term results.Publication Metadata only The Effects of Levosimendan Exposure on Oxidant/Antioxidant Status and Trace Element Levels in the Pulmonary Artery of Rats(2013-06-01T00:00:00Z) AY, YASİN; AYDIN, CEMALETTİN; Basel, Halil; Bektaş, Hava; Bulut, Gulay; İNAN, BEKİR; Ay, NURAY; Demir, Ismail; AY, YASİN; AYDIN, CEMALETTİN; İNAN, BEKİR; KAHRAMAN AY, NURAYWe investigated both the effect of levosimendan and the role of oxidant/antioxidant status and trace element levels in the pulmonary artery of rats. Fourteen male Wistar albino rats were randomly divided into two groups of seven animals each. Group 1 was not exposed to levosimendan and served as a control. Levosimendan (12 mu g/kg) diluted in 10 ml 0.9 % NaCl was administered intraperitoneally to group 2. Animals of both groups were killed after 3 days, and their pulmonary arteries were harvested to determine changes in tissue oxidant/antioxidant status and trace element levels. The animals in both groups were killed 72 h after the levosimendan exposure treatment, and pulmonary arteries were harvested to determine levels of the lipid peroxidation product MDA and the antioxidant GSH as well as the decreased activity of antioxidant enzymes such as SOD, GSH-Px and CAT. It was found that MDA levels increased in pulmonary artery tissues of rats after levosimendan administration. The GSH level decreased in the pulmonary artery of rats after levosimendan treatment. Co, Mn, Fe, Cd and Pb levels were significantly higher (P < 0.001) and Mg, Zn and Cu levels significantly lower (P < 0.001) in the levosimendan group compared to the control group. These results suggest that levosimendan treatment caused an increase in free radical production and a decrease in antioxidant enzyme activity in the pulmonary artery of levosimendan-treated rats. It also caused a decrease or increase in the levels of many minerals in the pulmonary artery, which is an undesirable condition for normal pharmacological function.Publication Metadata only Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency(2020-08-01T00:00:00Z) AY, YASİN; Gunes, Esra; TÜRKKOLU, ŞEVKET TUNA; SELÇUK, Emre; ÇALIM, Muhittin; AKAL, Ramazan; AYDIN, CEMALETTİN; İNAN, BEKİR; KÖKSAL, CENGİZ; KAHRAMAN AY, Nuray; AY, YASİN; TÜRKKOLU, ŞEVKET TUNA; SELÇUK, EMRE; ÇALIM, MUHITTIN; AKAL, RAMAZAN; AYDIN, CEMALETTİN; İNAN, BEKİR; KÖKSAL, CENGİZ; KAHRAMAN AY, NURAYObjectives To compare traditional surgery with two minimally invasive endo-venous procedures in terms of their long-term effect on the quality of life in great saphenous vein insufficiency (GSV). Method This prospective observational study included 217 patients that underwent surgical stripping (n = 62), radiofrequency ablation (n = 70), or cyanoacrylate embolization (n = 85) for the treatment of GSV insufficiency. Venous Clinical Severity Score (VCSS) assessments were made, 36-item Short-Form Health Survey (SF-36) questionnaire and Chronic Venous Insufficiency quality of life Questionnaire (CIVIQ-14) were administered, before and 1 year after the treatments. Results Surgical stripping group had significantly higher closure rates than the other groups (p < 0.05). At 12 months, decrease in VCSS scores was less pronounced in the cyanoacrylate embolization group when compared to the other two groups (p < 0.05). Improvement in CIVIQ-14 scores was better in the radiofrequency ablation group when compared to the cyanoacrylate embolization group (p < 0.05). Surgical stripping or radiofrequency ablation groups performed better on several domains of SF-36, when compared to the cyanoacrylate embolization group. Conclusions Surgical stripping and radiofrequency ablation seem to provide a better quality of life results at one year in patients undergoing treatment for GSV insufficiency.Publication Metadata only The Last Option Before the Prosthetic Graft in Arteriovenous Fistula Formation: Brachiobasilic Vein Transposition(2011-04-01T00:00:00Z) İNAN, BEKİR; Aydin, Unal; Basel, Halil; Erkalp, Kerem; Yasar, Tahsin; Keskin, Sıddık; İNAN, BEKİRObjective: Simple arteriovenous fistulas created with cephalic vein provide good vascular access for hemodialysis. Brachiobasilic vein transposition (BBVT) and prosthetic graft (PG) are two alternative methods for vascular access if cephalic vein occlusion have occured. In this study we aimed to compared these two methods and determine the advantages of the procedure. Material and Methods: From June 2006 to April 2009, 83 patients who had undergone BBVT and PG procedures were analyzed retrospectively. The cases were evaluated with their follow up data of 24 months. Trombosis, patency, infection, revision and infection rates were determined with Chi Square and Fischer-s Exact tests. Results: No significiant difference was determined between the groups for demographic data and risk factors. However, trombosis (p=0.021), patency (p=0.040), infection (p=0.001) and revision (p=0.001) rates of BBVT group were superior to PG group. Mortality was similar in both groups (p=0.46). Conclusion: BBVT procedure with high patency and low infection rate is an efficient, safe and preferred method for vascular access.