Person: ZENGİN KURT, BELMA
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Publication Metadata only Synthesis and Cytotoxic Activity of New Sorafenib / Ruthenium Complexes,(2020-02-27T00:00:00Z) Zengin Kurt, Belma; Çakma, Elmas Begüm; Öztürk, Dilek; Dağ, Aydan; Benkli, Kadriye; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK; DAĞ, AYDANPublication Metadata only Novel metal complexes containing 6-methylpyridine-2-carboxylic acid as potent α-glucosidase inhibitor: synthesis, crystal structures, DFT calculations, and molecular docking(2020-01-01T00:00:00Z) Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; ZENGİN KURT, BELMA; Dege, Necmi; ZENGİN KURT, BELMAPublication Metadata only Synthesis and Antibacterial Activity of New Sulfonamide Derivatives Containing Thiazolidine Ring(2020-03-01T00:00:00Z) Dandin, Gülnur; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; ZENGİN KURT, BELMA; GAZİOĞLU, IŞILPublication Metadata only A new series of asymmetric bis-isatin derivatives containing urea/thiourea moiety: Preparation, spectroscopic elucidation, antioxidant properties and theoretical calculations(2021-09-05T00:00:00Z) YAKAN, Hasan; Serdar ÇAVUŞ, M.; KURT, BELMA; MUĞLU, Halit; SÖNMEZ, Fatih; GÜZEL, Emre; ZENGİN KURT, BELMA© 2021 Elsevier B.V.In the present study, design, synthesis, characterization, and investigation of antioxidant properties of novel asymmetric bis-isatin derivatives (1-8) containing urea/thiourea moiety are reported for the first time. FT-IR, 1H-NMR, and 13C-NMR spectroscopic methods and elemental analysis were used to elucidate the structures of the synthesized compounds. Their CUPRAC and ABTS cation radical scavenging abilities were investigated for antioxidant activity. The bis-isatins containing urea moiety (compounds 1-4) did not show ABTS activity, while those containing the thiourea moiety (compounds 5-8) showed moderate ABTS activity. Besides, all bis-isatins were observed to exhibit CUPRAC activity at a low micromolar level The 1-(5-chloro-2-oxoindolin-3-ylidene)-5-(2-oxoindolin-3-ylidene)thiocarbonohydrazide (compound 5) showed the highest ABTS activity with IC50 value of 18.44 µM; on the other hand, the 1-(5-chloro-2-oxoindolin-3-ylidene)-5-(5-methoxy-2-oxoindolin-3-ylidene)carbonohydrazide (compound 2) had the strongest CUPRAC activity with A0.50 value of 0.600 µM. Both spectroscopic and antioxidant properties of the compounds were examined computationally, and the structure-activity relationship was investigated theoretically by comparing with experimental data. The ground state geometries and chemical reactivity parameters of the compounds were calculated using the B3LYP hybrid functional with 6-311++g(2d,2p) and 6-31g(d) basis sets. After determining the local electron affinity of the compounds, the Laplacian bond order and intrinsic bond strength indexes (independent gradient model-δgIGMH and IBSIIGMH descriptors based on Hirshfeld approach) of hydrogen bonds at possible reactive sites were calculated and associated with the antioxidant properties of the compounds.Publication Open Access Biological activities and chemical composition of Turkish sweetgum balsam (Styrax liquidus) essential oil(2022-01-01T00:00:00Z) BÜYÜKKILIÇ ALTINBAŞAK, BETÜL; İSSA, GHASSAN; ZENGİN KURT, BELMA; DEMİRCİ, BETÜL; BÜYÜKKILIÇ ALTINBAŞAK, BETÜL; ZENGİN KURT, BELMAObjective: The purpose of this present study was to make a chemical analysis of the composition of essential oil obtained from sweetgum balsam and to examine its antimicrobial, anticholinesterase, α-glucosidase inhibition, and antioxidant activities. Methods: The essential oil obtained by the hydrodistillation method was analyzed by gas chromatography-mass spectrometry systems. The antimicrobial activities of the essential oil were evaluated by disc diffusion and resazurin microplate methods, the anticholinesterase effect was determined by using in vitro AChE and BChE enzymes inhibition assays, and the antioxidant effect was evaluated by ABTS and CUPRAC methods. Results: The main components of the essential oil were determined as styrene (92.6%) and α-pinene (2.2%). The essential oil showed weak antimicrobial activity against K. pneumoniae, S. epidermidis but strong antimicrobial activity against A. baumannii, C. glabrata. It showed moderate inhibitory activity to AChE and BChE enzymes, and IC50 values were calculated as 36.5 μg/mL and 69.5 μg/mL, respectively. It also showed low inhibition of α-glucosidase (IC50 value was 637.2 μg/mL) and a similar antioxidant effect in the CUPRAC and ABTS method (A0.5 value was 637.2 μg/mL and IC50 value was 632.2 μg/mL, respectively). Conclusion: Styrax Liquidus essential oil can be considered a natural antimicrobial agent due to its strong antimicrobial activity capacity against A. baumannii and C. glabrata strainsPublication Metadata only Concentration effects on optical properties, DFT, crystal characterization and α-glucosidase activity studies: Novel Zn(II) complex(2021-12-05T00:00:00Z) Dege, Necmi; Özge, Özgen; Avcı, Davut; Başoğlu, Adil; Sönmez, Fatih; Yaman, Mavişe; Tamer, Ömer; Atalay, Yusuf; ZENGİN KURT, BELMA; ZENGİN KURT, BELMA© 2021 Elsevier B.V.A novel Zn(II) complex of 6-ClpicH and picH was synthesized and its structure was determined by XRD technique. The detailed experimental optical susceptibility and band gap, refractive index, linear polarizability, optical and electrical conductivity parameters in various concentrations were investigated by means of the UV–Vis spectroscopic data. The optical band gap, refractive index (n), linear optical susceptibility (χ(1)), third-order nonlinear optical susceptibility (χ(3)), second- and third-order nonlinear optical (β and γ) parameters were examined by using DFT/M06-L and ωB97XD/6–311++G(d,p) levels. The IC50 value of Zn(II) complex against α-glucosidase was also obtained at 0.44 mM. The experimental band gap of the Zn(II) complex at 13, 33, 44 and 94 µM concentrations in ethanol were found to be 4.38, 4.37, 4.35 and 4.28 eV, respectively. The third-order NLO susceptibility χ(3) parameter at 94 µM concentration corresponding to the photon energies of 4.6 and 5.7 eV in the UV–Vis region were observed at 206.6 × 10-13 and 294.3 × 10-13 esu, respectively. Besides, the theoretical χ(3) values were obtained at 50.58 × 10−13 and 20.37 × 10−13 esu by using M06-L level. These results indicate that Zn(II) complex could be an effective third-order NLO candidate material. In brief, the detailed theoretical and experimental structural, spectral and optical properties of the Zn(II) complex were presented comparatively.Publication Metadata only Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine(2021-08-01T00:00:00Z) SEVGİ, ECE; DAĞ, AYDAN; Kizilarslan-Hancer, Cagla; ATASOY, SEZEN; ZENGİN KURT, BELMA; Aksakal, Oznur; SEVGİ, ECE; DAĞ, AYDAN; KIZILARSLAN HANÇER, ÇAĞLA; ATASOY, SEZEN; ZENGİN KURT, BELMAEthnopharmacological relevance: Dittrichia viscosa (L.) Greuter (& ldquo;Sari ot, Yapis & cedil;kan andiz otu & rdquo; in Turkish) is a medicinal plant that has been traditionally used in the Mediterranean area. This plant is used by the local population for the treatment of cancer. Investigation of their biological activities is therefore very important to be supported by scientific basis for traditional use.Publication Metadata only The impact of Ir doping on the electrical properties of YbFe1−xIrxO3 perovskite-oxide compounds(2020-01-01T00:00:00Z) Coskun, M.; Polat, O.; Coskun, F.M.; Kurt, BELMA; Durmus, Z.; Caglar, M.; Turut, A.; ZENGİN KURT, BELMAPublication Metadata only Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors(2021-10-01T00:00:00Z) Ozten, Ozge; ZENGİN KURT, BELMA; Sonmez, Fatih; Dogan, Berna; Durdagi, Serdar; ZENGİN KURT, BELMA© 2021 Elsevier Inc.In the present study, new tacrine derivatives containing carbamate group were synthesized and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were evaluated. All synthesized compounds inhibited both cholinesterases at nanomolar level. Among them, ((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl(3-nitrophenyl) carbamate (6k) showed the best inhibitor activity against AChE and BuChE with IC50 value of 22.15 nM and 16.96 nM, respectively. The calculated selectivity index revealed that the synthesized compounds (exclude 6l) have stronger inhibitory activity against BuChE than AChE. The most selective compound was 2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl(4-methoxyphenyl)-carbamate (6b) with the selectivity index of 0.12. Molecular modeling approaches were employed to understand the interaction between the synthesized compounds and proteins. As carbamate derivatives can act as pseudo-irreversible inhibitors of AChE and BuChE, covalent docking approaches was applied to determine the binding modes of novel compounds at binding sites of cholinesterase enzymes.Publication Metadata only Glycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy.(2020-03-25T00:00:00Z) Omurtag Ozgen, Pinar Sinem; Zengin Kurt, Belma; Atasoy, SEZEN; Durmus, Zehra; Yigit, Gülşah; Dağ, Aydan; ATASOY, SEZEN; ZENGİN KURT, BELMA; DAĞ, AYDANCarbon-based nanomaterials (CNMs) have attracted great attention in biomedical applications such as cancer imaging and therapy. CNMs, which are currently used in a wide range of applications, suffer from drawbacks of toxicity and low biocompatibility. Either noncovalent or covalent functionalization of CNMs with hydrophilic and biocompatible polymers which help to block hydrophobic interactivity between CNMs and cells can greatly increase their biocompatibility by eliminating their probable toxicity towards living organisms. In this report, we present a comparison of both noncovalent and covalent functionalization approaches in order to introduce a biocompatible glycoblock copolymer onto multi-walled carbon nanotubes (CNTs) in order to enhance their potential in therapies. An anticancer drug (doxorubicin, Dox) was conjugated with two different end functionalized poly(1-O-methacryloyl-beta-d-fructopyranose-b-(2-methacryloxyethoxy))benzaldehyde glycoblock copolymers, which were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, by either noncovalent or covalent tethering. CNTs were coated separately with the synthesized drug-conjugated glycoblock copolymers and folic acid (FA) to obtain an efficient drug delivery platform for dual-targeting of glucose transporter protein (GLUT5) and folic acid receptors (FR) in breast cancer. A library of synthesized monomers, polymers and prepared glycoblock copolymer coated CNTs (hybrid-CNTs) using both approaches were comprehensively characterized by various techniques. Transmission electron microscopy measurements showed the homogeneous, smooth morphology of the prepared Dox-conjugated glycoblock copolymer coating of CNTs and confocal laser scanning microscopy images displayed successful cellular internalization of hybrid-CNTs in the MCF-7 and MDA-MB-231 human breast cancer cell lines. This research demonstrates the potential of hybrid-CNTs as a biocompatible drug delivery system as well as in vitro use of Dox-conjugated vehicles for dual receptor mediated breast cancer therapy.