Person: UYSAL, HARUN
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Publication Metadata only Comparison of Cytokine Hemadsorption as an Immunomodulator Therapy in COVID-19 Patients with and without Bacterial Sepsis(2022-10-01) Koc S.; Hanikoglu F.; Dokur M.; Polat Y.; Celebi S.; Koc S. G.; Kupeli I.; UYSAL H.; UYSAL, HARUN© 2022 Verlag Klinisches Labor GmbH. All rights reserved.Background: In this retrospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in COVID-19 ICU patients with or without sepsis. Methods: The levels of PCT, CRP, and ferritin were determined as indicators of infection/sepsis; the levels of interleukins (IL-6, IL-8 and IL-10, and TNF-α) were determined as indicators of cytokine storm were compared. APACHE score, SOFA score, and mortality rates were compared for the progression of the disease in 23 COVID-19 patients. Results: The therapy was generally successful in reducing the levels of IL-6, IL-8, IL-10, and TNF-α but the levels measured after the procedure did not differ among the patients with or without sepsis, suggesting that the presence of sepsis did not affect the efficacy and function of the cytokine hemadsorption procedure in COVID-19 patients. All parameters were reduced after the procedure except the levels of PCT and ferritin and mortality rates of patients diagnosed with sepsis. The level of PCT was significantly higher in these patients compared with the patients without sepsis while the ferritin and mortality did not show any significant difference between the two groups, suggesting that the cytokine hemadsorption may be safe in the treatment of critical COVID-19 patients. Conclusions: As a result, the progression of sepsis in COVID-19 may be avoided with cytokine hemadsorption applied as an immunomodulator therapy. However, this therapy should be further explored and validated prior to its introduction to everyday clinical practice when the epidemic conditions end.Publication Metadata only Utility of the gastro-laryngeal tube during transesophageal echocardiography: A prospective randomized clinical trial.(2022-12-16) Calim M.; Uysal H.; Kahraman Ay N.; Karaaslan K.; Daskaya H.; ÇALIM, MUHITTIN; UYSAL, HARUN; DAŞKAYA, HAYRETTİNPublication Metadata only Determining the Length of Stay in the Intensive Care Unit of Patients With Sepsis Who Underwent Hemoadsorption Using the Artificial Neural Networks Model(2022-03-01) Koç S.; Uysal H.; UYSAL, HARUNObjectives: The artificial neural network (ANN) analysis was used to predict the exact staying period of patients with sepsis have undergone hemoadsorption hospitalized in the General Intensive Care Unit (ICU) of X University Hospital. Methods: ANN model was successfully developed having 21 neurons in total (11 neurons at the first level, 9 neurons at the second level, and 1 neuron at the third level) using a computer program. The created network was trained using our real data and the fermi function of the system was determined by the program and then the program was able to predict possible staying time prior to real-time. Main variables of interest: Staying periods (days), ages, number of comorbidities, hemoperfusion periods (days), blood pH, C-Reactive Protein, procalcitonin, and blood lactate levels were inputs. Results: Predicted values were plotted to real data and the determination coefficient was found to be r2= 0.802. This relation was found to be good to predict the possible staying times of patients with sepsis treated using hemoadsorption in the ICU for a better organization and reducing the total cost. Conclusion: The artificial neural network modeling and this prediction were found to be useful for predicting patients staying time at ICUPublication Metadata only General Anesthesia versus Sedation in Multi ParametricMagnetic Resonance Imaging (mpMRI) TransrectalUltrasound Guided (TRUS) Fusion Targeted Prostate Biopsy:A Prospective, Randomized Study(2022-03-01) Uysal H.; Koç S.; UYSAL, HARUNObjectives: Different anesthetic methods have been used in multi-parametric magnetic resonance imaging-guided (mpMRI) transrectal ultrasound guidance (TRUS) fusion-targeted prostate biopsy, but the consensus on the optimal anesthetic approach is not clear. In this study, the anesthesia management, procedural conditions, intraoperative adverse events, complications, discharge criteria, and cancer detection rates of general anesthesia and sedation were compared. Methods: Participants were randomly divided into general anesthesia (GA) and sedation (S) groups. The primary endpoint of the study was the surgical satisfaction score. The incidence of hypoxia, patient satisfaction, cancer detection rate, anesthetic agent consumption, recovery and hospitalization times, and complication rates were all compared as secondary outcomes. Results: There was no significant difference in the incidence of hypoxemia in both groups (Group G:0, Group S:2 patients, p=0.494). While there was no significant difference in surgical satisfaction scores (Group GA: 9.48 vs Group S: 9.23, p=0.353). PC detection rates (p=0.809) and complication rates were similar. Conclusion: With similar surgical conditions, complication incidence, and cancer detection rates, neither anesthesia approach did not provide surgical superiority over the other. The sedation approach, combined with careful monitoring of anesthesia depth, prevented hypoxemia, reduced anesthetic agent consumption, and allowed for faster recovery and discharge, allowing for ambulatory anesthesia.Publication Metadata only Analysis of the effects of ha-330 hemo adsorption column application on mortality andmorbidity of adult patients with sepsis in general intensive care unit(2022-03-01) Koç S.; Dokur M.; Uysal H.; UYSAL, HARUNSepsis is a leading cause of mortality and morbidity in critical care units. The objective of this study is to evaluate if using the HA-330 Sepsis Adsorption Column in the intensive care unit reduces mortality and morbidity in patients with sepsis. This study was designed as a retrospective study evaluating demographic and laboratory parameters in the General Intensive Care Unit. The study involved 200 sepsis patients who were followed in the critical care unit between June 2019- December 2020 and were treated with the HA-330 Sepsis Adsorption Column. The length of hemoperfusion in patients who died was statistically significantly longer than in patients who recovered. The mean lactate and the hemoperfusion time/day value had a weak but significant negative correlation. In the recovery and death observations, the improvements in repeated C-reactive protein and Procalcitonin measurements were statistically significantly different. The differences in repeated pH and lactate measurements in the recovery and mortality observations were statistically identical, according to the observations. Sepsis-related deaths are a severe issue in critical care units. HA-330 Sepsis Adsorption Column, it can be thought that it can be an inexpensive, useful, and effective method that can be used in the prognosis of the patients. In antibiotic-resistant sepsis, hemoperfusion may be recommended.