Person: GÖNCÜ, BEYZA SERVET
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Publication Metadata only Paratiroit Hücre İzolasyonunda Enzimatik ve Mekanik İzolasyon Yöntemlerinin Karşılaştırılması(2018-05-04T00:00:00Z) Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAHPublication Metadata only A comparative study of parathyroid transport solution and university of Wisconsin solution: effect on calcium-sensing receptor and vitamin-D receptor during cold ischemia in parathyroid tissue(2019-09-16T00:00:00Z) Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ; KAZANCIOĞLU, RÜMEYZA; ERSOY, YELIZ EMINEPublication Metadata only Paratiroit Nakli İmmünolojisi(2019-04-01T00:00:00Z) Ayşan, Mustafa Erhan; Göncü, Beyza Servet; Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAHParatiroit nakli, kalıcı hipoparatiroidinin tek tedavi seçeneğidir. Diğer organ nakillerinde olduğu gibi greft fonksiyonunun artırılması için alıcı-verici uyumu paratiroit nakli için de çok önemlidir. Paratiroit nakli (bazı özel vakalar dışında) doğası gereği immünsupresyonsuz olarak gerçekleştirilmek zorunda olduğu için başarılı nakiller yapmak oldukça güçtür. Bu güçlüğü aşabilmek için elimizde güvenilir parametreler olmalıdır. İlk paratiroit naklinin yapılmasından günümüze kadar geçen yaklaşık 100 yıl içinde ne yazık ki A, B, 0 uyumu dışında üzerinde konsensus sağlanan bir kriter yoktur. Literatürde bu konudaki bilgi miktarı yetersiz olduğu gibi üstelik var olan bilgilerin doğruluğu da şüphelidir. Konu üzerinde daha fazla çalışma yapılmalıdır. Bu gerçekleşene kadar paratiroitte immünsüpresyon yapılmaksızın yüksek başarı oranıyla ve uzun greft fonksiyonu gösteren allo-nakiller yapmak zor görünmektedir.Publication Metadata only Kalsiyum ve D Vitamini Metabolizmasında Görevli Transkripsiyon Faktörlerin Kültüre Edilen Paratiroit Dokularındaki Etkinliklerinin Paratiroit Nakil Sürecine Etkisi(2019-11-01T00:00:00Z) Yücesan, Emrah; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVETPublication Metadata only Minor histocompatibility antigen sp110: an evolutionary trace for parathyroid tissue(2019-09-15T00:00:00Z) Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINEPublication Metadata only Paratiroit Hücrelerinin Mikroenkapsülasyonu ve Nakil Yöntemi(2018-11-29T00:00:00Z) Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAHPublication Metadata only Importance of HLA typing, PRA and DSA tests for successful parathyroid allotransplantation.(2019-07-01T00:00:00Z) Yucesan, Emrah; Goncu, B; Ozdemir, B; Idiz, O; Aysan, E; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINEPublication Metadata only Parathyroid Allotransplantation From Cadaveric Donor: Case Study(2017-09-25T00:00:00Z) Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; KAZANCIOĞLU, RÜMEYZAPublication Metadata only Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up(2017-11-01) YUCESAN, Emrah; GONCU, Beyza; Basoglu, HARUN; KANDAS, Nur Ozten; Ersoy, YELİZ EMİNE; Akbas, FAHRİ; Aysan, Erhan; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; BAŞOĞLU, HARUN; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİBackground: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear.Publication Open Access HLA Class I Expression Changes in Different Types of Cultured Parathyroid Cells.(2019-04-17T00:00:00Z) Goncu, B; Kandas, NO; Yucesan, Emrah; Aysan, E; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAHObjectives: Tissue-specific immunogenicity can be characterized by the determination of human leukocyte antigens (HLA). Parathyroid hyperplasia tissue cells are presumed to have the ability to lose HLA class I expression profile during cultivation, whereas healthy parathyroid cells are presumed to already express HLA class I molecules at low levels. However, there are conflicting results about the expression of HLA class I antigens. In this study, our aim was to evaluate different patterns of HLA class I expression in different parathyroid tissue cells. Materials and Methods: Parathyroid tissue cells were isolated enzymatically and cultured in vitro. Expression of HLA class I (HLA-A, HLA-B, HLA-C) mRNA and protein levels were studied in 7 parathyroid adenomas and 9 parathyroid hyperplasia tissue samples by reverse transcriptase-polymerase chain reaction and Western blot analyses. Results: HLA-A protein expression remained stable in parathyroid adenoma and hyperplasia tissue, but HLA-A mRNA expression decreased in adenoma tissue. In parathyroid hyperplasia tissue, HLA-B protein expression remained stable, although mRNA expres sion levels decreased during cultivation. HLA-C mRNA expression was steady in parathyroid adenoma yet significantly decreased in hyperplasia tissue samples. HLA-C protein expression levels were below 30 pg for both types of parathyroid tissue during cultivation. Conclusions: HLA class I expression levels of para thyroid hyperplasia and adenoma tissue were not found to be similar. Parathyroid hyperplasia tissue is the donor tissue for the treatment of permanent hypoparathyroidism. Therefore, expression patterns of HLA class I are directly relevant to the transplant process. In particular, the HLA region is highly polymorphic, and, as a consequence of this, heterogeneous correlations among HLA-A, HLA-B, and HLA-C expression patterns of parathyroid tissue should be evaluated in detail before transplant for future studies.
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