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GÜRSOY, AZIZE ESRA

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AZIZE ESRA
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GÜRSOY
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Type: Article × Start date: 2020 × End date: 2021 ×

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Now showing 1 - 3 of 3
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    Therapeutic plasma exchange in neuroimmunologic disease: 60 patients experience
    (2021-01-01T00:00:00Z) USLU, FERDA; GÜRSOY, AZİZE ESRA; USLU, FERDA; GÜRSOY, AZIZE ESRA
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    CREUTZFELDT-JAKOB DISEASE: A SINGLE CENTER EXPERIENCE AND SYSTEMIC ANALYSIS OF CASES IN TURKEY
    (2020-05-01T00:00:00Z) Uslu, Ferda; Gokcal, Elif; GÜRSOY, Azize Esra; KOLUKISA, MEHMET; Yildiz, Gulsen Babacan; USLU, FERDA; GÖKÇAL, ELİF; GÜRSOY, AZIZE ESRA; KOLUKISA, MEHMET
    Introduction - We aimed to analyze the clinical, laboratory and neuroimaging findings in patients with sporadic Creutzfeldt-Jakob disease (CJD) in a single center as well as to review other published cases in Turkey.
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    Revisiting the complex architecture of ALS in Turkey: Expanding genotypes, shared phenotypes, molecular networks, and a public variant database
    (2020-08-01T00:00:00Z) Tunca, Ceren; Seker, Tuncay; Akcimen, Fulya; Coskun, Cemre; Bayraktar, Elif; Palvadeau, Robin; Zor, Seyit; Kocoglu, Cemile; Kartal, Ece; Sen, Nesli Ece; Hamzeiy, Hamid; Erimis, Aslihan Ozoguz; Norman, Utku; Karakahya, Oguzhan; Olgun, Gulden; Akgun, Tahsin; Durmus, Hacer; Sahin, Erdi; Cakar, Arman; Gursoy, Esra Baar; BABACAN YILDIZ, GÜLSEN; İŞAK, BARIŞ; ULUÇ, KAYIHAN; Hanagasi, Hasmet; Bilgic, Basar; TURGUT, NİLDA; Aysal, Fikret; Ertas, Mustafa; BOZ, CAVİT; Kotan, Dilcan; Idrisoglu, Halil; Soysal, Aysun; UZUN ADATEPE, Nurten; Akalin, Mehmet Ali; Koc, Filiz; Tan, Ersin; Oflazer, Piraye; Deymeer, Feza; Tastan, Oznur; ÇİÇEK, ABDULLAH ERCÜMENT; Kavak, Ersen; Parman, Yesim; Basak, A. Nazli; GÜRSOY, AZIZE ESRA; BABACAN YILDIZ, GÜLSEN
    The last decade has proven that amyotrophic lateral sclerosis (ALS) is clinically and genetically heterogeneous, and that the genetic component in sporadic cases might be stronger than expected. This study investigates 1,200 patients to revisit ALS in the ethnically heterogeneous yet inbred Turkish population. Familial ALS (fALS) accounts for 20% of our cases. The rates of consanguinity are 30% in fALS and 23% in sporadic ALS (sALS). Major ALS genes explained the disease cause in only 35% of fALS, as compared with similar to 70% in Europe and North America. Whole exome sequencing resulted in a discovery rate of 42% (53/127). Whole genome analyses in 623 sALS cases and 142 population controls, sequenced within Project MinE, revealed well-established fALS gene variants, solidifying the concept of incomplete penetrance in ALS. Genome-wide association studies (GWAS) with whole genome sequencing data did not indicate a new risk locus. Coupling GWAS with a coexpression network of disease-associated candidates, points to a significant enrichment for cell cycle- and division-related genes. Within this network, literature text-mining highlightsDECR1, ATL1, HDAC2, GEMIN4, andHNRNPA3as important genes. Finally, information on ALS-related gene variants in the Turkish cohort sequenced within Project MinE was compiled in the GeNDAL variant browser (www.gendal.org).