Person: GÖREN, AHMET CEYHAN
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Publication Open Access The phenolic contents, antioxidant and anticholinesterase activity of section Amaracus (Gled.) Vogel and Anatolicon Ietsw. of Origanum L. species(2020-04-01T00:00:00Z) Ozer, Zuleyha; GÖREN, AHMET CEYHAN; Kilic, Turgut; Oncu, Merve; Carikci, Sema; Dirmenci, Tuncay; GÖREN, AHMET CEYHANOriganum boissieri Ietsw., O. saccatum P.H.Davis, O. solymicum P.H.Davis and O. ayliniae Dirmenci & T.Yazici belonging to sect. Amaracus (Gled.) Vogel, O. sipyleum L. and O. hypericifolium O.Schwarz & P.H.Davis belonging to sect. Anatolicon Ietsw. were analyzed for their chemical composition of essential oil and phenolic components. The essential oil compositions were analysed by using GC-MS and GC-FID. The phenolic contents of the chloroform, acetone, and methanol extracts were analyzed using LC-MS/MS. Antioxidant activities of the extracts were investigated by using three methods; DPPH free radical scavenging activity, beta-carotene linoleic acid assays and CUPRAC assays. The essential oil compositions of the section Amaracus were found to be as carvacrol type (O. ayliniae, O. boissieri) and p-cymene type (O. saccatum, O. solymicum). In the section of Anatolicon, while O. sipyleum was found as gamma-terpinene type, O. hypericifolium was carvacrol type. In the extracts, the most abundant components were determined as flavonoids, coumaric acids and derivatives. Especially rosmarinic acid and penduletin were detected in high amounts. Among the studied species, extracts of O. ayliniae showed quite good activity for all methods. The extracts from all species showed remarkable antioxidant activity. Inhibition capability of the extracts against acetyl and butyrylcholinesterase enzymes (AChE and BChE) were determined. The extracts were found as inactive against AChE. The moderate inhibition capacity observed against BChE. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.Publication Metadata only Diterpenoid and phenolic contents of Sideritis hololeuca Boiss & Heldr. Apud Bentham with antioxidant and anticholinesterase activity(2020-05-01T00:00:00Z) Carikci, Sema; GÖREN, AHMET CEYHAN; Kilic, Turgut; GÖREN, AHMET CEYHANPublication Metadata only Ent-kaurene Diterpenoids from Sideritis lycia with Antiviral and Cytotoxic Activities(2020-07-01T00:00:00Z) Kilic, Turgut; TOPÇU, GÜLAÇTI; GÖREN, AHMET CEYHAN; AYDOĞMUŞ, Zeynep; KARAGÖZ, Ali; Yildiz, Yasar K.; Aslan, Irfan; TOPÇU, GÜLAÇTI; GÖREN, AHMET CEYHANThe genus Sideritis (Lamiaceae) is represented by 45 species (54 taxa) in Anatolia with high endemism ratio (74%), and Turkey is one of the gene centers of the genus along with Spain. Acetone extract of the aerial parts of Sideritis lycia afforded eight known ent-kaurene diterpenoids, structures of which have been identified as linearol, isolinearol, isosidol, sidol, siderol, sideridiol, 7-epi-candicandiol and foliol through 1H NMR, 13 C NMR and mass spectroscopic analyses. Cytotoxic and antiviral activities of the acetone extract, linearol, sidol and isosidol were investigated together with insecticidal activity of species. The antiviral index of linearol, isosidol and acetone extract of S. lycia were determined as 2.31, 2.01 and 2.58, respectively, except sidol. 7-Epi-candicandiol was found to be the most active diterpene against a series of cancer cell lines with ED50 values; KB (13.3 mu g/mL), COL-2 (11.8 mu g/mL), LU1 (17.9 mu g/mL), LNCaP (14.9 mu g/mL) and A2780 (9.0 mu g/mL). Activity results of this study indicated that ent-kaurane diterpenes have potential to be considered as antiviral and cytotoxic lead compounds.Publication Metadata only Determination of secondary metabolites of Origanum vulgare subsp. hirtum and O. vulgare subsp. vulgare by LC-MS/MS(2020-01-01T00:00:00Z) Ozer, Zuleyha; Carikci, Sema; Yilmaz, Hasibe; Kilic, Turgut; Dirmenci, Tuncay; GÖREN, AHMET CEYHAN; GÖREN, AHMET CEYHANSecondary metabolites of solvent extracts of Origanum vulgare subsp. hirtum and O. vulgare subsp. vulgare were determined using liquid chromatography-mass spectrometry (LC-MS/MS). Curcumin was used as an internal standard. Rosmarinic acid was determined as the main compound of studied extracts together with other phenolic acid derivatives. In LC-MS/MS analyses, relative standard deviations (RSD %) ranged between 0.11-9.47. The correlation values were found to be greater than 0.97 for each investigated analyte.Publication Metadata only Phytochemical Screening, Antioxidant and Anticholinesterase Activity of Origanum amanum Post Endemic to Turkey(2020-01-01T00:00:00Z) Carikci, Sema; GÖREN, AHMET CEYHAN; Kilic, Turgut; Dirmenci, Tuncay; GÖREN, AHMET CEYHANThe phenolic and essential oil profiles and, antioxidant and anticholinesterase activities (AChE and BChE inhibitory activities) of Origanum amanum Post endemic to Turkey were investigated. The oil was obtained by applying hydrodistillation method and analyzed by GC-MS/MS. The plant was extracted with chloroform (C), acetone (Ac) and methanol (M). The extracts were analyzed through LC-MS/MS and the phenolic compounds were determined in quantitative amounts. Inhibition of lipid peroxidation, Cu2+ and DPPH scavenging and anticholinesterase activity of the extracts were analyzed. The main compounds of the essential oil of O. amanum were determined as cymene, carvacrol and gamma-terpinene. Rosmarinic, t-ferulic and caffeic acids were determined as the main compounds of the extracts. While the extracts did not inhibit AChE, Ac extract inhibited BChE moderately. Moreover, acetone and methanol extracts of O. amanum showed good antioxidant activity.Publication Metadata only Essential oil composition of twenty-two Stachys species (mountain tea) and their biological activities(2011-12-01T00:00:00Z) Goren, AHMET CEYHAN; PIOZZI, Franco; Akcicek, Ekrem; Kilic, Turgut; Carikci, Sema; MOZIOGLU, Erkan; SETZER, William N.; GÖREN, AHMET CEYHANThe essential oils from twenty-two different Stachys species were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Thirty-nine compounds, which accounted for 70.5-97.8% of the total composition of the oils, have been identified. Germacrene-D (2.9-45.3%), beta-caryophyllene (2.3-62.3%), caryophyllene oxide (trace to 7.8%), spathulenol (trace to 7.8%) and alpha-cadinene (1.4-8.5%) have been identified as the main components of the essential oils. Antimicrobial assessments of the essential oils were evaluated against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Candida albicans by disc diffusion method. Most of the essential oils showed moderate activity against the studied microorganisms. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.Publication Metadata only Quantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activity(2018-07-01) Carikci, Sema; Kilic, Turgut; Ozer, Zuleyha; Dirmenci, Tuncay; ARABACI, TURAN; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHANIn this study, quantities of some phenolics; caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin in the directly methanol (M1), chloroform (C), acetone (Ac) and methanol (M2) extratcs obtained from Origanum laevigatum Boiss. from Turkey were investigated via liquid chromatography and tandem mass spectrometry (LC-MS/MS). Curcumin was used as an internal standard. Caffeic acid, chlorogenic acid, rosmarinic acid and gallic acid were determined as the most abundant phenolic acids in the studied extracts using LC-MS/MS. In LC-MS/MS measurements relative standard deviations (RSD %) for caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin were found to be 8.04, 5.21, 5.45, 3.73, 5.44, 4.85, 5.47 and 6.57 % respectively. For the investigated analytes, the correlation coefficient was found in the range of 0.9803 to 0.9981. Furthermore, antioxidant properties of the extracts were determined based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), beta-carotene linoleic acid and cupric (Cu2+) ion reducing power assay (CUPRAC). Acetone (Ac) and methanol (M2) extracts showed high activity in all test assays due to their high concentration of rosmarinic acid, caffeic acid and gallic acid in the extracts. (C) 2018 ACG Publications. All rights reserved.Publication Metadata only Metabolic profile and biological activity of Sideritis brevibracteata P. H. Davis endemic to Turkey(2017-01-01T00:00:00Z) Sagir, Zuleyha Ozer; Carikci, Sema; Kilic, Turgut; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHANEssential oil and phenolic compositions of Sideritis brevibracteata P.H. Davis, which is an endemic species in Turkey and commonly used as a herbal tea for some diseases, were determined by GC-MS and Liquid chromatography-mass spectrometry (LC-MS/MS) techniques. While the main components of the essential oil were determined as caryophyllene, germacrene-D, and -cadinene, the phenolic compounds quercetagetin-3,6-dimethylether and chlorogenic acid were found to be the main compounds in the extracts of the species. The characteristic diterpenoids of Sideritis species such as siderol, linearol, eubotriol, sideridiol, and athonolone were isolated and their structures were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) techniques. Weak inhibitory activity of species against butyryl-cholinesterase was determined. Antioxidant capacity of the acetone and methanol extracts was determined by DPPH free radical scavenging activity, -carotene linoleic acid assays, and CUPRAC assays.Publication Metadata only Screening of Chemical Composition, Antioxidant and Anticholinesterase Activity of Section Brevifilamentum of Origanum (L.) Species(2017-09-01T00:00:00Z) YILMAZ, Hasibe; Carikci, Sema; Kilic, Turgut; Dirmenci, Tuncay; ARABACI, TURAN; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHANSix Origanum species, Origanum acutidens (Hand. -Mazz.) Ietsw. (OA), Origanum brevidens (Bornm.) Dinsm. (OB), Origanum haussknechtii Boiss. (OC), Origanum husnucan-baseri H. Duman, Aytac & A. Duran (OHB), Origanum leptocladum Boiss. (OL), Origanum rotundifolium Boiss. (OR), belonging to sect. Brevifilamentum were analyzed for their essential oil and phenolic components. For the essential oil analyses, GC-MS and GC-FID were used. Phenolic contents of the aerial parts of the chloroform, acetone, and methanol extracts were analyzed using LC-MS/MS. Antioxidant activity of the species was investigated by three methods; DPPH free radical scavenging activity, beta-carotene linoleic acid assays and CUPRAC assays. Also, acetyl and butyrylcholinesterase inhibition of the extracts were investigated. While the essential oil contents of the section Brevifilamentum showed difference in chemotype, the phenolic contents were found to be coumaric acids and derivatives. These groups were the most abundant components of the extracts. Especially rosmarinic acid was detected in high amounts in acetone and methanol extracts. OA had the best activity both in antioxidant and anticholinesterase assays.Publication Metadata only Fatty acid composition and chemotaxonomic evaluation of species of Stachys(2012-01-01T00:00:00Z) Goren, AHMET CEYHAN; Akcicek, Ekrem; Dirmenci, Tuncay; Kilic, Turgut; MOZIOGLU, Erkan; YILMAZ, Hasibe; GÖREN, AHMET CEYHANThe fatty acid composition of the seed oil of 23 Stachys taxa was analysed by GC/MS. The main compounds were found to be linoleic (27.1-64.3%), oleic (20.25-48.1%), palmitic (4.3-9.1%), stearic (trace to 5.2%) and 6-octadecynoic (2.2-34.1%) acids. The latter compound could be used as a chemotaxonomic marker of the genus Stachys. A cluster analysis was performed for comparison and characterisation of the seed oil from Stachys species.