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GÖREN, AHMET CEYHAN

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Author: Kilic, Turgut × Author: Goren, AHMET CEYHAN ×

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    Essential oil composition of twenty-two Stachys species (mountain tea) and their biological activities
    (2011-12-01T00:00:00Z) Goren, AHMET CEYHAN; PIOZZI, Franco; Akcicek, Ekrem; Kilic, Turgut; Carikci, Sema; MOZIOGLU, Erkan; SETZER, William N.; GÖREN, AHMET CEYHAN
    The essential oils from twenty-two different Stachys species were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Thirty-nine compounds, which accounted for 70.5-97.8% of the total composition of the oils, have been identified. Germacrene-D (2.9-45.3%), beta-caryophyllene (2.3-62.3%), caryophyllene oxide (trace to 7.8%), spathulenol (trace to 7.8%) and alpha-cadinene (1.4-8.5%) have been identified as the main components of the essential oils. Antimicrobial assessments of the essential oils were evaluated against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Candida albicans by disc diffusion method. Most of the essential oils showed moderate activity against the studied microorganisms. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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    Quantitative determination of some phenolics in Origanum laevigatum Boiss. extracts via validated LC-MS/MS method and antioxidant activity
    (2018-07-01) Carikci, Sema; Kilic, Turgut; Ozer, Zuleyha; Dirmenci, Tuncay; ARABACI, TURAN; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHAN
    In this study, quantities of some phenolics; caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin in the directly methanol (M1), chloroform (C), acetone (Ac) and methanol (M2) extratcs obtained from Origanum laevigatum Boiss. from Turkey were investigated via liquid chromatography and tandem mass spectrometry (LC-MS/MS). Curcumin was used as an internal standard. Caffeic acid, chlorogenic acid, rosmarinic acid and gallic acid were determined as the most abundant phenolic acids in the studied extracts using LC-MS/MS. In LC-MS/MS measurements relative standard deviations (RSD %) for caffeic acid, (E)-ferulic acid, rosmarinic acid, chlorogenic acid, fumaric acid, gallic acid, pyrogallol and vanillin were found to be 8.04, 5.21, 5.45, 3.73, 5.44, 4.85, 5.47 and 6.57 % respectively. For the investigated analytes, the correlation coefficient was found in the range of 0.9803 to 0.9981. Furthermore, antioxidant properties of the extracts were determined based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), beta-carotene linoleic acid and cupric (Cu2+) ion reducing power assay (CUPRAC). Acetone (Ac) and methanol (M2) extracts showed high activity in all test assays due to their high concentration of rosmarinic acid, caffeic acid and gallic acid in the extracts. (C) 2018 ACG Publications. All rights reserved.
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    Metabolic profile and biological activity of Sideritis brevibracteata P. H. Davis endemic to Turkey
    (2017-01-01T00:00:00Z) Sagir, Zuleyha Ozer; Carikci, Sema; Kilic, Turgut; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHAN
    Essential oil and phenolic compositions of Sideritis brevibracteata P.H. Davis, which is an endemic species in Turkey and commonly used as a herbal tea for some diseases, were determined by GC-MS and Liquid chromatography-mass spectrometry (LC-MS/MS) techniques. While the main components of the essential oil were determined as caryophyllene, germacrene-D, and -cadinene, the phenolic compounds quercetagetin-3,6-dimethylether and chlorogenic acid were found to be the main compounds in the extracts of the species. The characteristic diterpenoids of Sideritis species such as siderol, linearol, eubotriol, sideridiol, and athonolone were isolated and their structures were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) techniques. Weak inhibitory activity of species against butyryl-cholinesterase was determined. Antioxidant capacity of the acetone and methanol extracts was determined by DPPH free radical scavenging activity, -carotene linoleic acid assays, and CUPRAC assays.
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    Screening of Chemical Composition, Antioxidant and Anticholinesterase Activity of Section Brevifilamentum of Origanum (L.) Species
    (2017-09-01T00:00:00Z) YILMAZ, Hasibe; Carikci, Sema; Kilic, Turgut; Dirmenci, Tuncay; ARABACI, TURAN; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHAN
    Six Origanum species, Origanum acutidens (Hand. -Mazz.) Ietsw. (OA), Origanum brevidens (Bornm.) Dinsm. (OB), Origanum haussknechtii Boiss. (OC), Origanum husnucan-baseri H. Duman, Aytac & A. Duran (OHB), Origanum leptocladum Boiss. (OL), Origanum rotundifolium Boiss. (OR), belonging to sect. Brevifilamentum were analyzed for their essential oil and phenolic components. For the essential oil analyses, GC-MS and GC-FID were used. Phenolic contents of the aerial parts of the chloroform, acetone, and methanol extracts were analyzed using LC-MS/MS. Antioxidant activity of the species was investigated by three methods; DPPH free radical scavenging activity, beta-carotene linoleic acid assays and CUPRAC assays. Also, acetyl and butyrylcholinesterase inhibition of the extracts were investigated. While the essential oil contents of the section Brevifilamentum showed difference in chemotype, the phenolic contents were found to be coumaric acids and derivatives. These groups were the most abundant components of the extracts. Especially rosmarinic acid was detected in high amounts in acetone and methanol extracts. OA had the best activity both in antioxidant and anticholinesterase assays.
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    Fatty acid composition and chemotaxonomic evaluation of species of Stachys
    (2012-01-01T00:00:00Z) Goren, AHMET CEYHAN; Akcicek, Ekrem; Dirmenci, Tuncay; Kilic, Turgut; MOZIOGLU, Erkan; YILMAZ, Hasibe; GÖREN, AHMET CEYHAN
    The fatty acid composition of the seed oil of 23 Stachys taxa was analysed by GC/MS. The main compounds were found to be linoleic (27.1-64.3%), oleic (20.25-48.1%), palmitic (4.3-9.1%), stearic (trace to 5.2%) and 6-octadecynoic (2.2-34.1%) acids. The latter compound could be used as a chemotaxonomic marker of the genus Stachys. A cluster analysis was performed for comparison and characterisation of the seed oil from Stachys species.