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GÖREN, AHMET CEYHAN

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AHMET CEYHAN
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2017 - 20183
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Author: Goren, AHMET CEYHAN × Author: GÖREN, AHMET CEYHAN × Rights: info:eu-repo/semantics/openAccess ×

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    Antioxidant activity and polyphenol content of Turkish thyme (Thymus vulgaris) monitored by liquid chromatography and tandem mass spectrometry
    (2017-01-01T00:00:00Z) KÖKSAL, EKREM; Bursal, Ercan; GÜLÇİN, İlhami; KORKMAZ, MUSTAFA; Caglayan, Cuneyit; Goren, AHMET CEYHAN; ALWASEL, Saleh H.; GÖREN, AHMET CEYHAN
    Like tea, the leaves of Turkish thyme (Thymus vulgaris) can be boiled in water to produce an extract. This is widely used as syrup for the treatment of coughs and bronchitis at alternative medicine clinics in many parts of the world. In the current study, we assessed the phenolic content and antioxidant activity of thyme. The antioxidant activities of both ethanol and aqueous extracts of thyme were determined using various in vitro methods. The total phenolic and total flavonoid contents were determined to be a gallic acid equivalent and a quercetin equivalent, respectively. Finally, the quantities of the phenolic compounds were detected using high-performance liquid chromatography and tandem mass spectrometry. The total phenolic compounds in the aqueous extract and ethanol extracts of Turkish thyme were 256.0 g gallic acid equivalent/mg dried extract and 158.0 g gallic acid equivalent/mg dried extract, respectively. Conversely, the total flavonoid compounds in both extracts were 44.2 g and 36.6 g quercetin equivalent/mg dried extract, respectively. For the first time, we determined phenolic contents and investigated the antioxidant potential of thyme. The results indicate that Turkish thyme is a good dietary source with phenolic properties.
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    Evaluation of the in vitro Anti-inflammatory Activity of Nerium oleander L. Flower Extracts and Activity-Guided Isolation of the Active Constituents
    (2018-03-01T00:00:00Z) Balkan, Irem Atay; Goren, AHMET CEYHAN; Kirmizibekmez, Hasan; Yesilada, Erdem; GÖREN, AHMET CEYHAN
    The in vitro anti-inflammatory activity profile of the Nerium oleander flower EtOH extract/its subextracts (n-hexane, CH2Cl2, EtOAc, remaining H2O) were evaluated on LPS induced Raw 264.7 macrophages. The effects of the crude EtOH extract and its subextracts on nitric oxide (NO) production and cell viability were determined. The most active subextract was determined to be the EtOAc subextract without exerting any toxicity towards Raw 264.7 macrophages. This subextract significantly inhibited NO production of Raw 264.7 macrophages after LPS induction (62.56 +/- 1.91% at 200 mu g/mL concentration). The levels of iNOS were reduced up to 67.50%. Moreover, this subextract slightly reduced the phosphorylation levels of MAP kinases (p-ERK, p-JNK, p-38). The highest inhibition was observed for ERK phosphorylation, which was inhibited by 20.53% at 200 mu g/mL concentration. Through activity-guided fractionation procedures, kaempferol, kaempferol 3-O-beta-glucopyranoside and chlorogenic acid were isolated as the main active components. The structures of the active compounds were determined by 2D-NMR techniques and HRMS analysis. All compounds significantly inhibited NO productions. Results of the present study supported the traditional use of N. oleander flowers to treat inflammatory complaints.
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    Screening of Chemical Composition, Antioxidant and Anticholinesterase Activity of Section Brevifilamentum of Origanum (L.) Species
    (2017-09-01T00:00:00Z) YILMAZ, Hasibe; Carikci, Sema; Kilic, Turgut; Dirmenci, Tuncay; ARABACI, TURAN; Goren, AHMET CEYHAN; GÖREN, AHMET CEYHAN
    Six Origanum species, Origanum acutidens (Hand. -Mazz.) Ietsw. (OA), Origanum brevidens (Bornm.) Dinsm. (OB), Origanum haussknechtii Boiss. (OC), Origanum husnucan-baseri H. Duman, Aytac & A. Duran (OHB), Origanum leptocladum Boiss. (OL), Origanum rotundifolium Boiss. (OR), belonging to sect. Brevifilamentum were analyzed for their essential oil and phenolic components. For the essential oil analyses, GC-MS and GC-FID were used. Phenolic contents of the aerial parts of the chloroform, acetone, and methanol extracts were analyzed using LC-MS/MS. Antioxidant activity of the species was investigated by three methods; DPPH free radical scavenging activity, beta-carotene linoleic acid assays and CUPRAC assays. Also, acetyl and butyrylcholinesterase inhibition of the extracts were investigated. While the essential oil contents of the section Brevifilamentum showed difference in chemotype, the phenolic contents were found to be coumaric acids and derivatives. These groups were the most abundant components of the extracts. Especially rosmarinic acid was detected in high amounts in acetone and methanol extracts. OA had the best activity both in antioxidant and anticholinesterase assays.