Person: DEMİREL, METİN
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Publication Open Access Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease(2023-06-01) Demirel M.; Köktaşoğlu F.; Özkan E.; Dulun Ağaç H.; Gül A. Z.; Sharifov R.; Sarıkaya U.; Başaranoğlu M.; Selek Ş.; DEMİREL, METİN; KÖKTAŞOĞLU, FATMANUR; DULUN AĞAÇ, HALİME; GÜL, AYŞE ZEHRA; SARIKAYA, UFUK; BAŞARANOĞLU, METİN; SELEK, ŞAHABETTİNObjectives: Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of excessive fat in the liver, which can lead to fibrosis and has an increasing prevalence. NAFLD requires non-invasive diagnostic biomarkers. While typically observed in overweight individuals, it can also occur in non-obese/non-overweight individuals. Comparative studies on non-obese NAFLD patients are scarce. This study aimed to conduct a using liquid chromatography-high resolution mass spectrometry (LC-MS/MS)-based metabolic profiling of non-obese NAFLD patients and healthy controls. Materials and methods: The patient group consisted of 27 individuals with NAFLD, while the healthy control group included 39 individuals. Both groups were between 18 and 40 years old, had a BMI of less than 25 and had alcohol consumption less than 20 g/week for men and 10 g/week for women. Serum samples were collected and analyzed using LC-MS/MS. The data were analyzed using the TidyMass and MetaboAnalyst. Results: The LC-MS/MS analyses detected significant changes in D-amino acid metabolism, vitamin B6 metabolism, apoptosis, mTOR signaling pathway, lysine degradation, and phenylalanine metabolism pathways in non-obese NAFLD patients. Significant changes were also observed in the metabolites D-pantothenic acid, hypoxanthine, citric acid, citramalic acid, L-phenylalanine, glutamine, and histamine-trifluoromethyl-toluidide, β-hydroxymyristic acid, DL-Lactic acid, and 3-methyl-2-oxopentanoic. Overall, the study provides valuable insights into the metabolic changes associated with non-obese NAFLD patients and can contribute to the development of non-invasive diagnostic biomarkers for NAFLD.Publication Metadata only K VİTAMİNİ ÖLÇÜM METODUNUN GELİŞTİRİLMESİ VE REFERANS ARALIĞININ BELİRLENMESİ(2022-10-26) Demirel M.; Selek Ş.; DEMİREL, METİN; SELEK, ŞAHABETTİNPublication Metadata only Measurement of vitamin K and its derivatives in human plasma through enzyme-assisted liquid chromatography-tandem mass spectrometry assay(2023-06-01) Demirel M.; Selek Ş.; DEMİREL, METİN; SELEK, ŞAHABETTİNPublication Metadata only Investigation of Trace Element and Oxidative Stress Parameters in Patients with Oral Glucose Tolerance Test(2018-11-27) Demirel M.; Yılmaz S.; Selek Ş.; DEMİREL, METİN; SELEK, ŞAHABETTİNPublication Metadata only Tip 2 Diyabetli Hastalarda; Antioksidan Mineraller ve Oksidatif Stresin Anksiyete ile İlişkisi(2022-10-26) Değer B.; Çakıcı Ç.; Güngör Z. B.; Tunç T.; Büyükuslu N.; Demirel M.; DEMİREL, METİN