Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Open Access Can CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?(2014-01-01T00:00:00Z) Sudolmus, Sinem; Koroglu, Nadiye; Yildirim, Gokhan; Ulker, Volkan; Gulkilik, Ahmet; DANSUK, RAMAZAN; DANSUK, RAMAZANObjective. The role of single preoperative serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer has been investigated. Methods. 176 patients diagnosed with epithelial ovarian carcinoma after staging laparotomy between January 2002 and May 2010 were evaluated retrospectively. Results. The mean, geometric mean, and median of preoperative serum CA-125 levels were 632,6, 200,29, and 191,5 U/mL, respectively. The cut-off value predicting lymph node metastases in the ROC curve was 71,92 U/mL, which is significant in logistic regression analysis (P = 0.005). The preoperative log CA-125 levels were also statistically significant in predicting lymph node metastasis in logistic regression analysis (P = 0.008). Conclusions. The tumor marker CA-125, which increases with grade independent of the effect of stage in EOC, is predictive of lymph node metastasis with a high rate of false positivity in Turkish population. The high false positive rate may obscure the predictive value of CA-125.Publication Metadata only Prostatic adenocarcinoma with initial metastatic spread to the mandible(2015-09-01T00:00:00Z) Cakmak, Ozgur; Tarhan, Huseyin; Kucuk, Ulku; Ilbey, YUSUF ÖZLEM; İLBEY, YUSUF ÖZLEMProstate cancer is one of the commonest types of malignancy in males. Although prostate cancer has a propensity to metastasize to the bone, metastasis to the mandible is rare. Because of their uncommon incidence, the diagnosis of mandibular metastasis, especially those originating from the prostate, may represent a challenge both for urologists and dentists. Here we present a case of prostatic adenocarcinoma with initial metastatic spread to the mandible.Publication Metadata only Synthesis of New Oleanane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines(2019-12-19) Dağ, Aydan; Topçu, Gülaçtı; Atasoy, Sezen; Aktaş, Asude Sena; Şenol, Halil; ŞENOL, HALIL; DAĞ, AYDAN; ATASOY, SEZEN; TOPÇU, GÜLAÇTIPublication Open Access Multiple myeloma mimicking metastatic lung cancer(2015-01-01) Furuncuoglu, Yavuz; Cirak, Yalcin; Turk, HACI MEHMET; BASAR, Melih; Ortapamuk, Hulya; KAUR, Ahmet Cemil; TÜRK, HACI MEHMETMultiple myeloma is a hematological malignancy characterized by a clonal proliferation of plasma cells in the bone marrow. Extramedullary dissemination of multiple myeloma is uncommon. Only in rare cases, the malignant plasma cells of multiple myeloma had infiltrated the lung parenchyma. In this case report, we presented a case of multiple myeloma with lung plasmacytoma, in a 42-year-old patient, hospitalized for pain and infiltrative mass in the right lung. The results of his initial evaluation with computed tomography and positron emission tomograpy scanning, resembled lung tumor with bone metastasis. Surprisingly, biopsies from lung tumor and bone metastasis, revealed malignant plasma cells. We found M spike in protein electrophoresis and lambda monoclonal band in immune electrophoresis. A bone marrow biopsy evaluation was done and justified multiple myeloma diagnosis before hematology referral. Multiple myeloma diagnosis at the age of 42 is quite rare.Publication Metadata only Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?(2016-04-01T00:00:00Z) Yakar, Fatih; Yakar, Aysun; BÜYÜKPINARBAŞILI, NUR; Erelel, Mustafa; BÜYÜKPINARBAŞILI, NURBackground: Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cell lung cancer (NSCLC) in a 2-year postoperative follow-up period.Publication Open Access Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia(2011-01-01T00:00:00Z) Sogut, S.; Yonden, Z.; Kaya, H.; Oktar, S.; Tutanc, M.; Yilmaz, H. R.; Yigit, A.; Ozcelik, N.; Gali, E.Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the study. Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV. In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1.4-fold lower and that of Ala/Val was 1.3-fold higher compared to the controls. No significant difference in genotype frequencies was found between patients and controls (chi(2) = 4.561, d.f. = 2, P = 0.101). The Val-9 was the most common allele in patient and healthy subjects. No significant difference in allele frequencies was found between patients and controls (chi(2) = 1.496, d.f. = 1, P = 0.221). We conclude that the Mn-SOD gene polymorphism is not associated with sickle cell anemia.Publication Open Access Fetal exposure to a diabetic intrauterine environment resulted in a failure of cord blood endothelial progenitor cell adaptation against chronic hypoxia(2015-01-01T00:00:00Z) Dincer, U. DenizGestational diabetes mellitus (GDM) has long-term health consequences, and fetal exposure to a diabetic intrauterine environment increases cardiovascular risk for her adult offspring. Some part of this could be related to their endothelial progenitor cells (EPCs). Understanding the vessel-forming ability of human umbilical cord blood (HUCB)-derived endothelial colony-forming cells (ECFCs) against pathological stress such as GDM response to hypoxia could generate new therapeutic strategies. This study aims to investigate the role of chronic hypoxia in EPCs functional and vessel-forming ability in GDM subjects. Each ECFC was expressed in endothelial and pro-angiogenic specific markers, namely endothelial nitric oxide synthase (eNOS), platelet (PECAM-1) endothelial cell adhesion molecule 1, vascular endothelial-cadherin CdH5 (Ca-dependent cell adhesion molecule), vascular endothelial growth factor A, (VEGFA) and insulin-like growth factor 1 (IGF1). Chronic hypoxia did not affect CdH5, but PECAM1 MRNA expressions were increased in control and GDM subjects. Control hypoxic and GDM normoxic VEGFA MRNA expressions and hypoxia-inducible factor 1-alpha (HIF1a) protein expressions were significantly increased in HUCB ECFCs. GDM resulted in most failure of HUCB ECFC adaptation and eNOS protein expressions against chronic hypoxia. Chronic hypoxia resulted in an overall decline in HUCB ECFCs- proliferative ability due to reduction of clonogenic capacity and diminished vessel formation. Furthermore, GDM also resulted in most failure of cord blood ECFC adaptation against chronic hypoxic environment.Publication Open Access Management of Patients with Granulomatous Mastitis: Analysis of 31 Cases(2012-01-01T00:00:00Z) KAYAHAN, Munire; Kadioglu, HÜSEYİN; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİNBackground: Granulomatous mastitis is a benign recurrent disease. Accurate diagnosis is only by histopathology. Patients and Methods: 31 cases with histological diagnosis were retrospectively analyzed. Results: Mean follow-up was 42.4 months for recurrent and 27.8 months for non-recurrent cases. Etiology was tuberculosis in 1 case. 5 cases (16%) relapsed. 6 patients (19.3%) treated with abscess drainage healed completely, but 50% relapsed. Relapses were treated with excision or steroids. Steroid therapy was the initial treatment in 12 cases (38.7%), with 1 relapse (8.3%) which was treated in the same manner. 2 patients had incomplete response necessitating excision, and another 2 developed abscesses which were treated with steroids or excision after drainage. Surgical excision was preferred in 12 cases (38.7%) due to suspicion for carcinoma in 8 patients (25.8%) and/or low probability of poor cosmetic outcome. All healed without complication, and recurrence was observed in 1 case (8.3%) which was treated with re-excision. Conclusion: Both excision and steroid therapy had low and similar relapse rates, but excision was superior to steroid therapy in providing strict diagnosis with much faster healing and fewer complications. In refractory cases, and when deformity is inevitable, steroid therapy should be preferred.Publication Metadata only The Protective Effect of Cinnamomum Zeylanicum in Streptozotocin-Induced Diabetic Rats(2019-03-29) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Open Access Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer(2018-09-01T00:00:00Z) YILMAZ, ERCAN; GÜL, MEHMET; MELEKOĞLU, RAUF; Coskun, Ebru Inci; Sahin, NURHAN; GÜL, SEMİR; BAŞTEMUR, AYŞE GÜLÇİN; Ciplak, Baris; ŞAHİN, NURHANObjectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.