Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Metadata only Prevalence of depressive symptoms in elderly cancer patients receiving chemotherapy and influencing factors.(2018-09-01T00:00:00Z) ATAG, E; MUTLAY, F; Soysal, PINAR; SEMIZ, HS; KAZAZ, SN; KESER, M; ELLIDOKUZ, H; KARAOGLU, A; SOYSAL, PINARPublication Open Access Prospective associations of cardiovascular disease with physical performance and disability : A longitudinal cohort study in the Osteoarthritis Initiative.(2019-11-05) Soysal, PINAR; Veronese, N; Stubbs, B; Koyanagi, A; Noventa, V; Bolzetta, F; Cester, A; Maggi, S; Jackson, SE; Loosemore, M; Demurtas, J; Smith, L; SOYSAL, PINARBackground Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal. Aims This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample. Methods This was an 8-year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements. Results The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8-year follow-up period than those without CVD (p= 0.006). Conclusion In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8-year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of followup. Importantly, no associations were observed when utilizing propensity score matching.Publication Metadata only When should orthostatic blood pressure changes be evaluated in elderly: 1st, 3rd or 5th minute?(2016-07-01T00:00:00Z) Soysal, PINAR; AYDIN, Ali Ekrem; Okudur, Saadet Koc; Isik, Ahmet Turan; SOYSAL, PINARDetection of orthostatic hypotension (OH) is very important in geriatric practice, since OH is associated with mortality, ischemic stroke, falls, cognitive failure and depression. It was aimed to determine the most appropriate time for measuring blood pressure in transition from supine to upright position in order to diagnose OH in elderly. Comprehensive geriatric assessment (CGA) including Head up Tilt Table (HUT) test was performed in 407 geriatric patients. Orthostatic changes were assessed separately for the 1st, 3rd and 5th minutes (HUT1, HUT3 and HUT5, respectively) taking the data in supine position as the basis. The mean age, recurrent falls, presence of dementia and Parkinson-s disease, number of drugs, alpha-blocker and anti-dementia drug use, and fasting blood glucose levels were significantly higher in the patients with versus without OH; whereas, albumin and 25-hydroxy vitamin D levels were significantly lower (p < 0.05). However, different from HUT3 and HUT5, Charlson Comorbidity Index and the prevalence of diabetes mellitus were higher, the use of antidiabetics, antipsychotics, benzodiazepine, opioid and levodopa were more common (p < 0.05). Statistical significance of the number of drugs and fasting blood glucose level was prominent in HUT1 as compared to HUT3 (p < 0.01, p < 0.05). Comparison of the patients that had OH only in HUT1, HUT(3)or HUT5 revealed no difference in terms of CGA parameters. These results suggests that orthostatic blood pressure changes determined at the 1st minute might be more important for geriatric practice. Moreover, 1st minute measurement might be more convenient in the elderly as it requires shorter time in practice. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Publication Metadata only Comment on -Does cognitive decline decrease health utility value in older adult patients with cancer?(2019-02-01) SOYSAL, PINAR; ARIK, Ferhat; SOYSAL, PINARPublication Metadata only Can sitagliptin a GLP-1 inhibitor, improve cognitive function in elderly diabetic patients with Alzheimer s disease(2012-07-19) IŞIK, AHMET TURAN; SOYSAL, PINAR; YAY, ADNAN; BABACAN YILDIZ, GÜLSEN; KISKAC, MUHARREM; KAZANCIOGLU, RÜMEYZA; SOYSAL, PINAR; BABACAN YILDIZ, GÜLSEN; KISKAÇ, MUHARREM; KAZANCIOĞLU, RÜMEYZAPublication Open Access Human Immunodeficiency Virus Infection and Diverse Physical Health Outcomes: An Umbrella Review of Meta-analyses of Observational Studies.(2019-08-11) Grabovac, I; Soysal, PINAR; Veronese, N; Stefanac, S; Haider, S; Koyanagi, A; Meilinger, M; ABBS, AD; Stubbs, B; McDermott, DT; Firth, J; Di, Gennaro; Demurtas, J; Jackson, SE; Yang, L; Smith, L; SOYSAL, PINARPublication Metadata only The effects of sitagliptin, a DPP-4 inhibitor, on cognitive functions in elderly diabetic patients with or without Alzheimer-s disease.(2017-01-01T00:00:00Z) Isık, At; Soysal, Pınar; Yay, A; Usarel, C; SOYSAL, PINARPublication Open Access Association between sarcopenia and diabetes: a systematic review and meta-analysis of observational studies(2019-10-01) Veronese, Nicola; Pizzol, Damiano; Demurtas, Jacopo; Smith, Lee; Sieber, Cornel; Strandberg, Timo; Bourdel-Marchasson, Isabelle; Sinclair, Alan; Petrovic, Mirko; Maggi, Stefania; SOYSAL, PINARAbstract Purpose Sarcopenia and diabetes are two common conditions in older people. Some recent literature has proposed that these two conditions can be associated. However, to date, no attempt has been made to collate this literature. Therefore, we aimed to summarize the prevalence of sarcopenia in diabetes (and vice versa) and the prevalence of sarcopenia in people with diabetes complications, through a systematic review and meta-analysis. Methods Two authors searched major electronic databases from inception until March 2019 for case control/cross-sectional/longitudinal studies investigating sarcopenia and diabetes. The strength of the reciprocal associations between sarcopenia and diabetes was assessed through odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders, where possible. Results From 953 potential eligible articles, 20 were included in the systematic review, with 17 providing data for meta-analysis. Overall, 54,676 participants were included (mean age = 65.4 years). Diabetic participants had an increased prevalence of sarcopenia compared to controls (n = 10; OR = 1.635; 95% CI 1.204-2.220; p = 0.002; I-2 = 67%), whilst, after adjusting for potential confounders, sarcopenia was associated with an increased odds of having diabetes (OR = 2.067; 95% CI 1.396-3.624; p < 0.0001; I-2 = 0%). In 1868 diabetic participants with a complication, there was an increased prevalence of sarcopenia (OR = 2.446; 95% CI 1.839-3.254; p < 0.0001; I-2 = 0%), as compared with those with no complication. Very limited data existed regarding studies with a longitudinal design. Conclusions Our study suggests a bidirectional association between diabetes and sarcopenia, particularly when diabetic complications are present.Publication Open Access Sarcopenia and health-related outcomes: an umbrella review of observational studies(2019-12-01) Veronese, Nicola; Demurtas, Jacopo; SOYSAL, PINAR; Smith, Lee; Torbahn, Gabriel; Schoene, Daniel; Schwingshackl, Lukas; Sieber, Cornel; Bauer, Jurgen; Cesari, Matteo; Bruyere, Oliviere; Reginster, Jean-Yves; Beaudart, Charlotte; Cruz-Jentoft, Alfonso J.; Cooper, Cyrus; Petrovic, Mirko; Maggi, Stefania; SOYSAL, PINARKey summary pointsAimTo investigate associations of sarcopenia with adverse health-related outcomes, through an umbrella review method.FindingsSarcopenia appears to be significantly associated with several adverse outcomes in older people, with a strong evidence for increased risk of mortality, disability, and falls.MessageSarcopenia is associated with several adverse health-related outcomes in older people, indicating the need of assessing this condition in daily practice. AbstractBackgroundThe clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture the scale of outcomes that have been associated with the presence of sarcopenia and systematically assess the quality, strength, and credibility of these associations using an umbrella review methodology.MethodsA systematic review in several databases was carried out, until 20th February 2019. For each association, random-effects summary effect size, 95% confidence intervals (CIs), heterogeneity (I-2), evidence for small-study effect, evidence for excess significance bias, and 95%-prediction intervals were estimated. We used these metrics to categorize the evidence of significant outcomes (p<0.05) from class I (convincing) to class IV (weak), according to pre-established criteria.ResultsFrom 358 abstracts, 6 meta-analyses with 14 associations were included. Sarcopenia was associated with higher risk of other comorbidities and mortality in 11 of 14 outcomes explored. However, only 3 outcomes (i.e., association between sarcopenia and increased risk of death in community-dwelling older people [odds ratio, OR=3.60; 95% CI 2.96-4.37; n=14,305], disability [OR=3.04; 95% CI 1.80-5.12; n=8569], and falls [OR=1.60; 95% CI 1.31-1.97; n=12,261]) presented a highly suggestive evidence (class II). Other association was classified as having only a weak evidence.ConclusionSarcopenia is associated with several adverse health-related outcomes in older people, and its associations with mortality, disability, and falls are supported by a highly suggestive evidence. The effect of interventions on sarcopenia to improve these outcomes needs to be investigated.Publication Metadata only Validity and Reliability of -AM SAD-, a Short Geriatric Depression Screening Tool, in Turkish Elderly People(2016-06-01T00:00:00Z) SOYSAL, PINAR; IŞIK, AHMET TURAN; USAREL, CANSU; KAYA, DERYA; ELLIDOKUZ, HULYA; GROSSBERG, GEORGE T; SOYSAL, PINARObjective: Depression is a serious public health problem among the elderly and screening for depression in the elderly for primary care physicians is essential. The objective of this study was to evaluate the validity and reliability of the AM SAD (Appetite, Mood, Sleep, Activity, and thoughts of Death) and to compare the results with DSM-5 depression criteria in Turkish elderly people.