Sağlık Hizmetleri Meslek Yüksekokulu
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Publication Metadata only A Comparison of Pelvipedal Casting and Titanium Elastic Nailing After Traction in the Treatment of Pediatric Femur Diaphysis Fractures(2013-06-01) POLAT, GÖKHAN; CEYLAN, HASAN HÜSEYİN; ERDİL, MEHMET EMİN; DEMİR, NECDET; BİLSEL, İSMAİL KEREM; TUNCER, NEJAT; UZER, GÖKÇER; BİLSEL, İSMAIL KEREM; UZER, GÖKÇERPublication Metadata only A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis(2017-01-01) Elbay, AHMET; Ozer, Omer Faruk; ALTINISIK, Muhammed; ELBAY, Arif Emre; Sezer, TAHA; Bayraktar, HAVVANUR; OZDEMIR, Hakan; ELBAY, AHMET; ÖZER, ÖMER FARUK; SEZER, TAHA; BAYRAKTAR, HAVVANUR; ÖZDEMİR, MEHMET HAKANWe investigated serum and aqueous humor thiol/disulfide (T-D) homeostasis in patients with cataracts versus healthy controls. In total, 56 patients with cataracts and 49 healthy controls were enrolled in this case-control study. Serum total thiol (TT), native thiol (NT), and disulfide (DS) concentrations were determined using a novel automated measurement method. Additionally, DS/TT, DS/NT and NT/TT percentage ratios were compared between the groups. In comparison with the control group, serum NT levels and aqueous humor TT and NT levels were significantly lower (p<.05, p<.05 and p<.001, respectively), whereas serum and aqueous humor DS levels were significantly higher in cataract patients (p<.01 and p<.001). DS/TT and DS/NT ratios were significantly higher and the NT/TT ratio was lower in cataract patients in serum (p<.005) and aqueous humor samples (p<.001). In conclusion, serum T-D homeostasis may be useful as biochemical markers, indicating the role of oxidative stress in the development of cataracts. Further studies are needed to confirm the pathophysiological role of T-D homeostasis in cataractogenesis.Publication Metadata only A Pilot Study Investigating the Impact of Topical Nasal Steroid Spray in Allergic Rhinitis Patients with Dry Eye.(2018-01-01) YENIGUN, A; Ozturan, ORHAN; OZDEMIR, MEHMET HAKAN; ELBAY, AHMET; DOGAN, REMZİ; YENİGÜN, ALPER; ELBAY, AHMET; DOĞAN, REMZI; ÖZTURAN, ORHAN; ÖZDEMİR, MEHMET HAKANPublication Open Access A Rare Case: Mucous Membrane Plasmacytosis in the Larynx(2014-07-01) BÜYÜKPINARBAŞILI, NUR; ÇOBAN, GANİME; GÜCİN, ZÜHAL; Meriç, Ayşenur; BÜYÜKPINARBAŞILI, NUR; ÇOBAN, GANİME; GÜCİN, ZÜHALMucous membrane plasmacytosis is a rare reactive process characterized by plasma cell infiltration of mucous membranes for unknown reasons. It may be confused with malignancy because of its exophytic structure and pavement appereances. A laryngeal polypoid lesion was sent to the pathology department, clinically called fibroma, and presented to emphasize the diagnostic and differential diagnostic criteria.Publication Metadata only A Rare Complication of Tuberculosis: Acute Paraplegia(2016-07-01) Aydin, TEOMAN; TASPINAR, Ozgur; Keskin, YAŞAR; KEPEKCI, Muge; GUNESER, Meryem; CAMLI, Adil; Seyithanoglu, Hakan; KIZILTAN, Huriye; Eris, ALİ HİKMET; AYDIN, TEOMAN; KESKİN, YAŞAR; ERİŞ, ALİ HİKMETBACKGROUND: Tuberculous radiculomyelitis(TBRM) is one of the complications of neurological tuberculosis and includes cases of arachnoiditis, intradural spinal tuberculoma or granuloma, and spinal cord complications of tuberculous meningitis (TBM). Here, we report a case of TBRM which presented with acute paraplegia.Publication Metadata only A Rare Entity: Bone Marrow Metastasis in a Patient with Wilms Tumour(2016-11-01) KAYGUSUZ, S. B.; CAKIR, F. B.; TUNA, R.; GULER, B.; COBAN, GANİME; Gucin, ZÜHAL; ÇOBAN, GANİME; GÜCİN, ZÜHALPublication Open Access A Six Sigma Trial For Reduction of Error Rates in Pathology Laboratory(2016-09-01) TURNA, Seval; Tosuner, ZEYNEP; Gucin, ZÜHAL; Kiran, TUĞÇE; Buyukpinarbasili, NUR; TASKIRAN, Olcay; Arici, DİLEK SEMA; TOSUNER, ZEYNEP; GÜCİN, ZÜHAL; KIRAN, TUĞÇE; BÜYÜKPINARBAŞILI, NUR; TURNA, SEVAL; ARICI, DILEK SEMAObjective: The aim of this study is to determine differences of levels of empathy among undergraduates in each year of their four-year programs of physiotherapy. Methods: During the 2014-2015 academic school year, 381 physiotherapy students were enlisted from two universities in Istanbul, one a foundation and the other a government university. The Turkish version of the Jefferson Scale of Physician Empathy was administered. Students were asked to indicate interest in particular physiotherapy specialties as well as their region of origin in Turkey. The Kruskal-Wallis analysis was used to determine differences among the four study years, and also to measure relationships between specialty interest, home-region, and empathy scores of the students. Empathy scores were also compared according to gender. Results: The difference of empathy scores between the students of the two universities was borderline significant (p=0.057). Empathy scores in both universities increased to a significant degree after school entrance and decreased in the final year. Levels of empathy did not change according to gender, specialty interest, or home-region (p=0.722, 0.524, and 0.309, respectively). Conclusions: This study points to the need for physiotherapy curricula that would enhance empathy and give students practice in exhibiting this valuable attribute. Additional studies are needed that would include larger study populations and track the same students year by year as to how and why their empathy levels change during their training.Publication Metadata only A skeletochronological study of age, growth and longevity in two freshwater turtles, Emys orbicularis and Mauremys rivulata from Mediterranean Turkey (Reptilia: Testudines).(2016-02-01) Ayaz, Dinçer; Çiçek, Kerim; KUMAŞ, MELTEM; Tok, Cemal Varol; KUMAŞ, MELTEMWe estimated growth parameters of Emys orbicularis and Mauremys rivulata in Mediterranean Turkey with the skeletochronological method, using specimens drowned in fyke nets. In adult E. orbicularis, the median age was 8 years in males and 10 years in females. The median age of adult M. rivulata was 10 years for both sexes. Both species reach sexual maturity at an age of 5-7 years. No difference was found in age composition between the sexes.Publication Metadata only Akciğer, meme ve kolon kanserli hastalarda oksidatif stres parametrelerinin değişimi(2019-01-01) ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; SELEK, ŞAHBETTİN; ÇOBAN, GANİME; KOÇYİĞİT, ABDÜRRAHİM; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; ÇOBAN, GANİME; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only All-arthroscopic, Guideless Single Suture-button Fixation of Acute Acromioclavicular Joint Dislocation: A Description of the Technique and Early Treatment Results(2017-06-01) ALTINTAŞ, BURAK; YILDIZ, FATİH; UZER, GÖKÇER; KAPICIOĞLU, MEHMET; BİLSEL, İSMAİL KEREM; YILDIZ, FATİH; UZER, GÖKÇER; KAPICIOĞLU, MEHMET; BİLSEL, İSMAIL KEREMPublication Metadata only An incidentally diagnosed uncommon anomalous flexor indicis profundus tendon(2016-01-01) AKMAN, ONUR; KELAHMETOĞLU, OSMAN; DUYGU, Cetin; GÜNEREN, ETHEM; AKMAN, ONUR; KELAHMETOĞLU, OSMAN; GÜNEREN, ETHEMPublication Open Access Analysis of Age as a Possible Prognostic Factor for Transcanalicular Multidiode Laser Dacryocystorhinostomy(2014-01-01) AYINTAP, Emre; BUTTANRI, Ibrahim Bulent; SADIGOV, Fariz; SERIN, Didem; ÖZSÜTÇÜ, Mustafa; Akkan, JÜLİDE CANAN; TUNCER, Kemal; UMURHAN AKKAN, JÜLİDE CANANPurpose. To assess the prognostic value of age on the outcome of transcanalicular multidiode laser dacryocystorhinostomy (TCL-DCR) in patients with acquired nasolacrimal duct obstruction (NLDO). Methods. The medical records of TCL-DCR performed between March 2009 and September 2013 were reviewed retrospectively. Inclusion criteria include over 20 years of age, similar mean follow-up period, and similar mean duration of stenting. The main outcome is surgical success. The effect of age on success rate is also evaluated. Results. The anatomical success was 52% in Group 1 (20-30 years), 56% in Group 2 (31-40 years), 64% in Group 3 (41-50 years), 76% in Group 4 (51-60 years), and 88% in Group 5 (over 60 years). The statistical difference among Group 1 and Group 5, in terms of surgical success rate, was found to be significant (P = 0.009). Additionally, the 20-30-year-old patients had a failure rate 6.76 times higher than that of the over-60-year-old patients (P = 0.009; 95% CI, 1.605-28.542). Conclusion. TCL-DCR is a surgical treatment option for NLDO for which a skin incision can be avoided. The success rate of TCL-DCR for younger population is lower when compared with elderly population.Publication Open Access Angioid streaks in a case of Camurati-Engelmann disease.(2017-07-01) ÖZDEMIR, HÜSEYİN; Tugcu, BETÜL; SEZER, TAHA; ELBAY, AHMET; TUĞCU, BETÜL; SEZER, TAHA; ELBAY, AHMET; ÖZDEMİR, MEHMET HAKANPublication Metadata only Ankaferd hemostat induces DNA damage, apoptosis and cytotoxic activity by generating reactive oxygen species in melanoma and normal cell lines(2017-01-01) Kocyigit, ABDÜRRAHİM; Guler, ERAY METİN; HAZNEDAROĞLU, İBRAHİM CELALETTİN; Malkan, Umit Yavuz; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNAlthough, Ankaferd hemostat (Ankaferd Blood Stopper, ABS) could be utilized successfully as hemostatic agent, studies demonstrated that it has cytotoxic effects on cells. However, the mechanism(s) of this effect has not been elucidated yet. In this study, cytotoxic, genotoxic, apoptotic and reactive oxygen generating (ROS) activities of ABS were investigated in melanoma and normal cell lines. The cells were incubated with different concentrations of ABS (0.125 to 2%) for 24 h. The cell viability was assessed based on ATP cell viability assay. Intracellular accumulation of reactive oxygen species (ROS) was determined using the fluorescent probes 2-,7--dichloro-dihydrofluoresce-in-diacetate (H2DCF-DA). DNA damage was evaluated by alkaline single cell gel electrophoresis assay (Comet Assay) and, apoptosis induction was detected by Acridine Orange/Ethidium Bromide AO/EB double staining method. Our results demonstrated that ABS increases DNA damage, apoptosis and ROS levels in both melanoma and normal cell lines in a dose dependent manner, and all of these activities were significantly higher in melanoma cells than in normal cells. There was a statistically significant positive correlation between DNA damage, apoptosis and ROS levels in ABS treated cell lines. Our results revealed that although ABS commonly used as hemostatic agent, it causes DNA damage and apoptosis by generating ROS in a dose dependent manner. Therefore, it should be removed the unused ABS by cleaning once the hemostasis is achieved to minimize the postoperative side effects. These results could also contribute to the development of new treatment for cancer.Publication Metadata only Anti-inflammatory and antioxidative properties of honey bee venom on Freund’xxs Complete Adjuvant-induced arthritis model in rats(2019-04-01) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KALELİ, SÜLEYMAN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNThe aim of this study was to assess anti-inflammatory, anti-oxidant, anti-genotoxic and immunomodulatory effects of honey bee venom (HBV) on adjuvant-induced arthritis in rats. Thirty-five rats were equally divided into a negative control (NC), a positive control (PC) and low, moderate and high doses (2, 4 and 20 mg/kg, respectively) of HBV treatment groups. Freund-s Complete Adjuvant (FCA) was given to the rats to form arthritis. The treatment groups were treated with HBV for 3 consecutive weeks. After the treatment, plasma IL-1 beta, IL-6, TNF-alpha, IFN-gamma and TGF-beta 1, total oxidant status (TOS), total antioxidant status (TAS) and myeloperoxidase (MPO) activities and mononuclear leukocyte (MNL) DNA damage levels were measured. Oxidative stress index (OSI) was calculated. IL-beta, IL-6, TNF-alpha, TGF-beta 1, IFN-gamma, TOS, OSI, DNA damage levels and MPO activities were significantly higher and TAS levels were lower in the PC group than the NC. After low-doses of HBV treatment IL-1 beta, IL-6, TNF-alpha, TGF-beta 1, TOS, OSI, MPO and MNL-DNA damage levels significantly decreased according to the PC, while IFN-gamma and TAS levels increased. The differences in moderate and high-dose HBV treatment groups were not as significant as low HBV doses. Low-doses of HBV has been shown to treat RA with anti-inflammatory and antioxidant effects, by preventing DNA damage. However, these effects have not been observed as strong at higher doses of HBV. In summary, HBV may be an effective option to ameliorate RA, but the optimization of the therapeutic dose has a crucial role.Publication Metadata only Are the effects of hemodialysis on ocular parameters similar during and after a hemodialysis session?(2017-09-01) Elbay, AHMET; ALTINISIK, M; DINCYILDIZ, A; KUTLUTÜRK, I; CANAN, J; AKKAN, U; KOYTAK, A; OZDEMIR, HÜSEYİN; ELBAY, AHMET; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİFPublication Metadata only ASSESSMENT OF PARAOXONASE AND ARYLESTERASE ANTIOXIDATIVE PARAMETERS IN RHEUMATIC DISEASES(2016-01-01) Keskin, YAŞAR; Aydin, TEOMAN; TAŞPINAR, ÖZGÜR; KEPEKÇİ, MÜGE; Ozer, O. F.; Selek, S.; Camli, AHMET ADİL; Mutluer, A. S.; KESKİN, YAŞAR; AYDIN, TEOMAN; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN; ÇAMLI, AHMET ADİLThe aim of this study is to evaluate the patient stress markers which has the early stage rheumatoid arthritis (RA). Blood samples were collected from the patients diagnosed with rheumatoid arthritis according to American Rheumatism Association ACR 2010 criteria, but not employed the medication of DMARD (Disease-modifying antirheumatic drugs) in order to examine the stress parameters of total oxidant status, total antioxidant status, paraoxonase, paraoxonase NaCl, arylesterase concentration. Twenty nine patients diagnosed with early stage RA and 61 healthy control group included in the study. Peripheral blood samples were examined for all the assays. The average age of the patients was 39.91 +/- 13.32 and their average BMI was 28.56 +/- 4.15. ESR and CRP values have been found significantly high levels in RA group when we compare with control group. OSI values, which means oxidant parameters, have been found significantly high compared to the control group. When the parameters of arylesterase were compared to the control group, the values of control group were significantly high.Publication Metadata only Association between cerebrovascular reactivity and severity of diabetic retinopathy in patients with diabetes mellitus(2015-04-01) YAMAN, A.; GULTEKIN, T. Ozdemir; DURUYEN, H.; ALTINISIK, M.; DENIZ, C.; Asil, TALİP; DENİZ, ÇİĞDEM; ASİL, TALIPPublication Open Access Association between etiology and lesion site in ischemic brainstem infarcts: a retrospective observational study.(2018-03-13) BARAN, GÖZDE; GULTEKIN, TO; BARAN, O; DENIZ, C; KATAR, SELAHATTİN; Yildiz, GÜLSEN; ASIL, TALİP; BARAN, GÖZDE; DENİZ, ÇİĞDEM; KATAR, SELAHATTİN; BABACAN YILDIZ, GÜLSEN; ASİL, TALIPBackground and purpose: To assess the anatomical distribution of the ischemic strokes of the brainstem, the effect of anatomical distribution on clinical features and prognosis, and the association between etiology and anatomical involvement. Methods: A retrospective search of the patient database of our institution was performed for a total of 227 patients who were admitted to the Department of Neurology, Medical Faculty of Bezmialem Vakif University between January 2012 and September 2014. Patients with adequate diagnostic data and 3-month follow-up visit were included in the study. Results: Twenty-one (9%), 136 (60%), and 65 (29%) patients had an infarction only at the mesencephalon, pons, and medulla, respectively. However, a single patient (0.5%) had an infarction both at the mesencephalon and pons, 3 (1.5%) at the pons and medulla, and 1 (0.5%) at the mesencephalon, pons, and medulla. While anterior involvement was more common in the mesencephalon and pons, posterior and lateral involvement occurred more frequently in the medulla. Large arterial atherothrombosis was the predominant cause of the strokes in all anatomical sites, particularly in infarcts involving the pons. Cardioembolic events were more common in patients with mesencephalic infarcts. Also, ischemia due to dissection was more common in infarctions involving the medulla, especially the lateral medulla. In subjects with simultaneous infarcts at other sites in addition to the brainstem, there was a significantly higher co-occurrence of medullary infarcts with cerebellar infarcts, mesencephalic infarcts with posterior cerebral artery infarcts, and pons infarcts with anterior circulation and multiple infarcts. Conclusion: Determination of risk factors and infarct localization as well as prediction of etiological parameters may assist in improving survival rates and therapeutic approaches.Publication Metadata only Association between nutritional status and Modic classification in degenerative disc disease(2016-04-01) TASPINAR, Ozgur; Seyithanoglu, Hakan; CAMLI, Adil; KIZILTAN, Huriye; HOCAOGLU, Ilknur Turk; Aydin, TEOMAN; Keskin, YAŞAR; Ozder, ACLAN; Eris, ALİ HİKMET; DENIZLI, Ebru; KEPEKCI, Muge; SEYİTHANOĞLU, MEHMET HAKAN; AYDIN, TEOMAN; ERİŞ, ALİ HİKMET; ÖZDER, ACLAN; KESKİN, YAŞAR[Purpose] This study was conducted to examine the association between Modic classification and the eating habits in patients with degenerative disc disease (DDD) and to determine the influence of nutrition on disease severity. [Subjects and Methods] Sixty patients with DDD visiting a low back pain outpatient clinic were enrolled. Through face-to-face interviews, they completed questionnaires regarding their demographics, disease activity, smoking and alcohol use, concomitant diseases, disease duration, and nutritional status. Exclusion criteria were age 65 years, other comorbidities, missing MRI data, and inability to speak Turkish. [Results] Forty patients were finally included in the study. The frequency with which they consumed water, salt, fast food, eggs, milk, yogurt, cheese, whole wheat bread, white bread, butter, and margarine was recorded. A weak negative correlation was observed between the Modic types and fish and egg consumption. [Conclusion] Modic changes, which indicate the severity of DDD, seem to be correlated to patients- dietary habits. However, studies with comparison groups and larger samples are needed to confirm our promising results before any cause-and-effect relationship can be proposed.