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Publication Open Access A CADASIL Case Presenting with Progressive Bulbar Palsy Caused by Acute Simultaneous Multiple Subcortical Infarcts(2019-04-01T00:00:00Z) GÖKÇAL, ELİF; KOLUKISA, MEHMET; Mustafayev, Nihat; ASİL, Talip; GÖKÇAL, ELİF; KOLUKISA, MEHMET; ASİL, TALIPCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an adult-onset inherited small vessel disease of the brain caused by NOTCH3 mutations. Clinical characteristics of CADASIL include recurrent infarctions, migraine with aura, mood disturbances and cognitive impairment. We report a 35 year-old migraine-free patient with unusual presentation with acute simultaneous multiple subcortical infarctions causing progressive bulbar palsy as the initial manifestation. Hepresented with slurred speech progressing to anarthria and bilateral palsy of lower motor cranial nerves within 24 hour. Initial acute subcortical infarcts enlarged and new infarcts developed in bilateral hemispheres. There was diffuse leukoencephalopathy involving temporal horns and the patient had positive familiy history of migraine and young stroke. CADASIL was diagnosed genetically when NOTCH3 mutationwas shown. The patient improved after treatment with liquid hydration and antiplatelet agent. We experienced with the patient that CADASIL may present with unusual progressive manifestations and bilateral simultaneous infarctions. Irrespective of clinical presentation, patients with leukoencephalopathy and positive familiy history should be tested for NOTCH3 mutation.Publication Open Access A Case of Primary Hypoparathyroidism Presenting with Acute Kidney Injury Secondary to Rhabdomyolysis.(2016-01-01) SUMNU, A; AYDIN, Z; GURSU, MELTEM; UZUN, S; KARADAG, S; CEBECI, E; OZTURK, S; Kazancioglu, RÜMEYZA; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZASymmetric calcification of the basal ganglia identified radiographically occurs in a variety of familial and nonfamilial conditions. Primary Familial Brain Calcifications (PFBC), which were known by many names previously, including Fahr disease and striopallidodentate calcinosis, are a genetic disease characterized by various mutations in four separate genes and autosomal dominant inheritance [1–4]. PFBC may present with various psychiatric and neurological symptoms [5]. On the other hand, many secondary causes, either infectious, toxic, or metabolic, have been described to cause symmetrical basal ganglion calcifications and so are in the differential diagnosis of PFBC [6]. Parathyroid diseases such as hypoparathyroidism, pseudohypoparathyroidism, and pseudo-pseudohypoparathyroidism are in the forefront among the metabolic causes. Idiopathic or postsurgical hypoparathyroidism is the most common cause of symmetric calcification of the basal ganglia [7–9]. Herein, a case of primary hypoparathyroidism with severe tetany, rhabdomyolysis, and acute kidney injury (AKI) is presented.Publication Open Access A Case Report of Tongue Edema due to Laryngeal Mask with Introducer(1.10.2018) Daskaya, Hayrettin; Ciftci, Taner; Idin, Kadir; Gul, Kursat; Topuz, Ufuk; Olculu, HakkiAirway management using a laryngeal mask is an especially preferred noninvasive technique because of its achievement of hemodynamic stability and ease of application in surgeries that have short surgery time and do not require specific positions such as the prone position. Although it is easily performed, serious complications may manifest rarely because of lack of experience and inappropriate choice of instrumentation. In this case report, clinical management and treatment options of tongue edema that developed because of the forgotten introducer in laryngeal mask application are presented.Publication Metadata only A clinical variant in SCN1A inherited from a mosaic father cosegregates with a novel variant to cause Dravet syndrome in a consanguineous family(2015-07-01) Tuncer, FN; Altıokka uzun , G; Gormez, Z; Calik , M; Yuksel, B; Sagiroglu, MS; Iscan, AKIN; Yuceturk , B; Ugur Iseri, SA; Bebek, N; Baykan, B; Ozbek , U; İŞCAN, AKINA consanguineous family from Turkey having two children with intellectual disability exhibiting myoclonic, febrile and other generalized seizures was recruited to identify the genetic origin of these phenotypes. A combined approach of SNP genotyping and exome sequencing was employed both to screen genes associated with Dravet syndrome and to detect homozygous variants. Analysis of exome data was extended further to identify compound heterozygosity. Herein, we report identification of two paternally inherited genetic variants in SCN1A (rs121917918; p.R101Q and p.I1576T), one of which was previously implicated in Dravet syndrome. Interestingly, the previously reported clinical variant (rs121917918; p.R101Q) displayed mosaicisnn in the blood and saliva of the father. The study supported the genetic diagnosis of affected children as Dravet syndrome possibly due to the combined effect of one clinically associated (rs121917918; p.R101Q) and one novel (p.I1576T) variants in SCN1A gene. This finding is important given that heterozygous variants may be overlooked in standard exome scans of consanguineous families. Thus, we are presenting an interesting example, where the inheritance of the condition may be misinterpreted as recessive and identical by descent due to consanguinity and mosaicism in one of the parents. (C) 2015 Elsevier B.V. All rights reserved.Publication Metadata only A clinically unsuspected nasopharyngeal sarcoidosis.(2016-05-01) TUGRUL, SELHATTİN; GOKTAS, SS; OZUCER, B; SÖNMEZ, FATMA CAVİDE; Özturan, ORHAN; TUĞRUL, SELAHATTİN; SÖNMEZ, FATMA CAVİDE; ÖZTURAN, ORHANPublication Metadata only A Clinico-Pathological Study of Transvaginal Endometrial ThicknessMeasurement in Asymptomatic Postmenopausal Patients and Patientswith Postmenopausal Bleeding(2019-05-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; ATEŞ, SEDA; gürbüz, tuğba; ŞAHİN, NURHAN; takmaz, taha; GÖKMEN KARASU, AYŞE FİLİZ; ATEŞ, SEDA; ŞAHİN, NURHANPublication Metadata only A comparison of extracorporeal shock wave therapy, physiotherapy, and local steroid injection in treatment of lateral epicondylitis(2016-03-01T00:00:00Z) AKKURT, SONER; Yilmaz, Ahmet; SAKA, TOLGA; SAKA, TOLGAObjectives: This study aims to compare the efficacy of extracorporeal shock wave therapy (ESWT), physiotherapy, and local steroid injection in the treatment of lateral epicondylitis.Publication Open Access A Comparison of Pregabalin and Ketamine in Acute Pain Management After Laparoscopic Cholecystectomy(2017-10-01T00:00:00Z) Haliloglu, Murat; BİLGİLİ, BELİZ; ÜLGEN ZENGİN, SENİYYE; Ozdemir, Mehtap; Yildirim, Ahmet; Bakan, Nurten; ÜLGEN ZENGİN, SENİYYEObjective: Pregabalin and ketamine are popular analgesic adjuvants for improving perioperative pain management. We designated this double-blind, placebo controlled study to test and compare the preventive effects of pregabalin and ketamine on postoperative pain management after elective laparoscopic cholecystectomy.Publication Open Access A comparison of the prevalence of orthostatic hypotension between older patients with Alzheimer-s Disease, Lewy body dementia, and without dementia.(2019-09-01) Soysal, PINAR; Aydin, AE; Isik, AT; Smith, L; Kocyigit, SE; SOYSAL, PINARPublication Metadata only A High-Performance Liquid Chromatographic Method for the Determination of Meropenem in Serum.(2019-11-18T00:00:00Z) Dincel, D; Sagirli, O; Topcu, GÜLAÇTI{{abstract}}Publication Open Access A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study(2018-01-01) GÜL AMUK, NİSA; KURT, GÖKMEN; YANDIM KARTAL, MELIS; ADAN, AYSUN; BARAN, YUSUF; KURT, GÖKMENThe aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were used for this preliminary study. MSCs were obtained from bones of two animals and were labeled with green fluorescent protein (GFP). Four animals were randomly selected for MSC injection, while 4 animals served as a control group. Samples were prepared for histological analysis, Cox-2 mRNA expression polymerase chain reaction analysis, and fluorescent microscopy evaluation. The number of total cells, number of osteoclastic cells, and Cox-2 mRNA expression levels of the periodontal tissue of teeth were calculated. The number of total cells was increased with MSC injections in PDL significantly (P < 0.001). The number of osteoclastic cells and Cox-2 mRNA expression were found to be similar for the two groups. GFP-labeled MSCs were observed with an expected luminescence on the smear samples of the PDL with transferred MSCs. The results of this preliminary study demonstrate successful evidence of transferring MSCs to intact PDL in a nonsurgical way and offer a minimally invasive procedure for transfer of MSCs to periodontal tissues.Publication Metadata only A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study(1.02.2018) Tekgunduz, Emre; Yilmaz, Mehmet; Erkurt, Mehmet Ali; Kiki, Ilhami; Kaya, Ali Hakan; Kaynar, Leylagul; Alacacioglu, Inci; Cetin, Guven; Ozarslan, Ibrahim; Kuku, Irfan; Sincan, Gulden; Salim, Ozan; Namdaroglu, Sinem; Karakus, Abdullah; Karakus, Volkan; Altuntas, Fevzi; Sari, Ismail; Ozet, Gulsum; Aydogdu, Ismet; Okan, Vahap; Kaya, Emin; Yildirim, Rahsan; Yildizhan, Esra; Ozgur, Gokhan; Ozcebe, Osman Ilhami; Payzin, Bahriye; Akpinar, Seval; Demirkan, FatihThrombotic microangiopathies (TMAs) are rare, but life-threatening disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia (MAHAT) associated with multiorgan dysfunction as a result of microvascular thrombosis and tissue ischemia. The differentiation of the etiology is of utmost importance as the pathophysiological basis will dictate the choice of appropriate treatment. We retrospectively evaluated 154 (99 females and 55 males) patients who received therapeutic plasma exchange (TPE) due to a presumptive diagnosis of TMA, who had serum ADAMTSI3 activity/antiADAMTS13 antibody analysis at the time of hospital admission. The median age of the study cohort was 36 (14-84). 67 (43.5%), 32 (20.8%), 27 (17.5%) and 28 (18.2%) patients were diagnosed as thrombotic thrombocytopenic purpura (TTP), infection/complement-associated hemolytic uremic syndrome (IA/CAHUS), secondary TMA and TMA-not otherwise specified (TMA-NOS), respectively. Patients received a median of 18 (1-75) plasma volume exchanges for 14 (153) days. 81 (52.6%) patients received concomitant steroid therapy with TPE. Treatment responses could be evaluated in 137 patients. 90 patients (65.7%) achieved clinical remission following TPE, while 47 (34.3%) patients had non-responsive disease. 25 (18.2%) non-responsive patients died during follow-up. Our study present real-life data on the distribution and follow-up of patients with TMAs who were referred to therapeutic apheresis centers for the application of TPE. (C) 2018 Elsevier Ltd. All rights reserved.Publication Metadata only A new alien species record for the flora of Turkey: Proboscidea louisianica (Miller) Thell.(2017-10-01) SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; Yılmaz, Hatice; Akkaya, Muhammed; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLAPublication Open Access A Novel External Fixator Designed for a More Comfortable and Secure Hip Arthroscopy(2022-01-01T00:00:00Z) Pulatkan, Anil; UÇAN, VAHDET; YILDIZ, FATİH; TUNCAY, İBRAHİM; UÇAN, VAHDET; YILDIZ, FATİH; TUNCAY, İBRAHİMObjective: To evaluate the functional results of a novel external fixator (EF) designed for joint distraction and prevention of traction table-related hip arthroscopy complications Methods: After obtaining promising results in a cadaveric study, 21 hips of 20 patients underwent EF-assisted arthroscopic hip surgeries for femoroacetabular impingement (FAI) and/or labral tear treatments. Patients were operated on a standard operating table in the supine position. A novel EF was used to distract the joint for central hip arthroscopy. The time needed for EF application and joint distraction and the amount of joint distraction were recorded. Preoperative functional scores were retrospectively compared to the postoperative 5-year follow-up results using the Harris Hip and Western Ontario and McMaster Universities Index scores. Results: All patients underwent peripheral and central arthroscopy. The mean time for EF application and joint distraction was 19 min (range: 8-21). The mean amount of joint distraction was 13.2 mm (range: 12-18). None of the arthroscopic procedures had to be converted to open surgery. Functional results of all patients were improved at the 5-year follow-up (p<0.01). Only one patient required hip arthroscopy revision due to residual FAI. No other major or minor complication was found that is related to the EF or arthroscopy itself. Conclusion: Mid-term outcomes following EF-assisted hip arthroscopy demonstrate significant improvement in the functional outcomes without traction table-related complications. EF can be used as an alternative to traction table to maintain adequate hip distraction in arthroscopic hip surgery. In addition to the rotation, a novel designed EF allows hip joint flexion during distraction contrary to traction table.Publication Metadata only A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS: AN EXPERIMENTAL ANIMAL STUDY(1.07.2019) Kunduz, Enver; Dincel, Zeyneb Afra; Seker, Busra; Saylak, Hatice Kubra; Demir, Okan; Akbulut, Huseyin; Aysan, ErhanObjective: Bleeding is one of the major complications of surgical procedures. Severe bleeding can be seen after liver injury. Various methods have been described in the literature for stopping liver bleeding such as compression, Pringle maneuver, and other hemostatic agents have been used. In this study, the use of anti-inflammatory, antioxidant, antimicrobial, analgesic, and anticoagulant agents described in the literature were evaluated for hemostatic efficacy following liver injuries. Materials and Methods: In this study 28 Wistar albino female / male rats from out-bred production were used. Animals were divided in 4 groups. After liver damage model creation, various herbal substances were applied to the liver. Hematocrit and platelet counts were measured. In addition, for histopathologic changes in the liver parenchyma, the rats were sacrificed, and the liver was resected. Results: The amount of bleeding (p: 0.001) and the preoperative and postoperative hematocrit changes (p: 0.009) were statistically significant between the groups. There was no significant difference in connective tissue growth (p: 0.065) and necrosis (p: 0.062). There were significant differences in inflammation and without karyorrhexis (p: 0.003). Discussion: Histopathological examinations showed that the groups using active agents had more connective tissue and karyorrhexis. Therefore these tissues could help to stop bleeding.Publication Metadata only A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS:AN EXPERIMENTAL ANIMAL STUDY(2019-03-01) KUNDUZ, ENVER; DİNCEL, Zeyneb Afra; ŞEKER, Büşra; SAYLAK, HATİCE KÜBRA; DEMİR, Okan; Akbulut, HÜSEYİN; Ayşan, MUSTAFA ERHAN; KUNDUZ, ENVER; AKBULUT, HÜSEYİN; AYŞAN, MUSTAFA ERHANPublication Metadata only A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF)(2015-01-01T00:00:00Z) Tunali, MUSTAFA; Özdemir, Hakan; Küçükodaci, Zafer; EZİRGANLI, Şeref; Bariş, Emre; Akman, Serhan; ATAY, Arzu; Firatli, Erhan; TUNALI, MUSTAFAPublication Open Access A Pathological Process Should be Carefully Conducted in the Breast: Mucocele-Like Lesion(2018-04-01) Gucin, ZÜHAL; GÜCİN, ZÜHALMucoccic-like lesion (MLL) of the breast has been firstly described as a benign lesion resembling mucinous carcinoma of the breast. Subsequently, it has also been reported to be associated with ductal hyperplasia or breast carcinoma. The risk of cancer development in the long term is unknown. Therefore, the approach to pure MLL of the breast detected during percutaneous biopsy is controversial. In this report, a mucocele-like breast lesion in a 47-year-old woman was first noticed during a core biopsy and later detected to be associated with ductal carcinoma in-situ focuses in excisional biopsy material is presented. The aim of this paper was to provide an overview of this rare and controversial lesion and its variabilities with regard of the presented case.Publication Open Access A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis(2013-01-01T00:00:00Z) Demir, Saliha Eroglu; Aytekin, Ebru; Ozgonenel, Levent; REZVANİ, AYLİN; Dogan, Yasemin Pekin; Caglar, Nil Sayiner; Ozaras, Nihal; Okur, Sibel Caglar; AYDIN, Teoman; Tutun, Sule; Guler, Mustafa; REZVANİ, AYLİN; AYDIN, TEOMANObjectives: The primary aim of this study was to assess the possible relationship among the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and two Ankylosing Spondylitis Disease Activity Score (ASDAS) including the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) scores in patients with ankylosing spondylitis (AS). The secondary aim was to investigate gender differences in terms of disease activity scores and functional status.Publication Open Access A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel(2022-06-01T00:00:00Z) Gokkaya, Bengisu; Atasoy, Sezen; ÇIRAKOĞLU, AYŞE; ARGÜDEN, YELDA; KURU, RAHİYE DİLHAN; YILMAZ, ŞÜKRİYE; ÖNGÖREN, ŞENİZ; DEVİREN, AYHAN; ATASOY, SEZENObjective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. Fin diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyorype or unsuccessful karyoryping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study. Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenctic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.