Diş Hekimliğinde Uzmanlık Tezleri
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Browsing Diş Hekimliğinde Uzmanlık Tezleri by Subject "ANXA1"
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Publication Open Access Polikistik over sendromlu kadınlarda cerrahi olmayan periodontal tedavinin ıl-6, ıl-10 ve anxa-1 seviyeleri üzerine etkisinin değerlendirilmesi / Evaluation of the effect of non-surgical periodontal treatment on il-6, il-10 and anxa-1 levels in women with polycystic ovary syndromeCAN YAŞAR, CANSU; GÜNPINAR, ŞADİYEPolycystic ovary syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism, polycystic ovaries, and ovulatory dysfunction, affecting 4-21 % of women worldwide. It has been shown that PCOS has an impact on both local and systemic proinflammatory markers, along with periodontal disease, but the relationship between them remains unclear. The aim of this study is to compare the clinical and biochemical response to periodontal treatment between individuals with PCOS and gingival inflammation and those with systemic health, as well as to investigate the role of annexin-1 (ANXA1) biomarker in gingival inflammation. A total of 80 participants were included, 40 individuals diagnosed with PCOS and 40 systemically healthy volunteers. Following periodontal examinations of all individuals, they were divided into four groups: a) PCOSPS (diagnosed with PCOS and healthy periodontium, n=20), b) PKOSG (diagnosed with PCOS and gingivitis, n=20), c) SG (systemically healthy individuals with gingivitis, n=20), and d) SPS (systemically healthy individuals with healthy periodontium, n=20). After gynecological and ultrasonographic examinations, as well as recording anthropometric measurements of all participants, hormonal tests were analysed. For the evaluation of periodontal status, clinical periodontal measurements were taken at the beginning of the study and at the 6th week after non-surgical periodontal treatment (NSPT) in the gingivitis groups. Gingival crevicular fluid (GCF) and saliva samples were collected at the beginning of the study and repeated at the 6th week after NSPT to assess the levels of interleukin-6 (IL-6), IL-10, and ANXA1. Biochemical analysis of all samples was performed using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis revealed that in the PCOS groups, the modified Ferriman-Gallwey index, LH/FSH ratio, DHEAS, and AS values were higher (p<0.05), while the FSH value was lower (p<0.05) compared to the systemically healthy groups. Improvement in bleeding on probing and plaque index scores, as well as a decrease in GCF volume (p<0.001) were observed after NSPT. The initial concentrations of IL-6, IL-10, and ANXA1 in GCF were higher in periodontally healthy groups (p<0.05). Additionally, an increase in concentration levels was detected in the gingivitis groups after NSPT (p<0.05). Salivary IL-6 concentration decreased (p<0.05) after NSPT in the gingivitis groups, while IL-10 and ANXA1 concentrations remained unchanged (p>0.05). According to the results of ROC analysis, the area under the curve (AUC) value for GCF ANXA1 was 0.974, with a sensitivity of 90% and specificity of 95% (p<0.0001). Within the limitations of this study, it was concluded that the improvement in clinical and biochemical parameters following gingivitis treatment is similar in women with PCOS and systemically healthy. Moreover, it was found that the concentration of GCF ANXA1 has high discriminative ability for gingival inflammation.