Kurt, BELMASonmez, FatihGÖKÇE, BaşakErgun, AdemGencer, NahitDemir, TakiArslan, OktayKucukislamoglu, Mustafa2019-10-052019-10-052016-09-01Kurt B., Sonmez F., GÖKÇE B., Ergun A., Gencer N., Demir T., Arslan O., Kucukislamoglu M., -In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives-, RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, cilt.42, ss.506-511, 2016https://hdl.handle.net/20.500.12645/8919Coumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of carbonic anhydrase I and II with a series of coumarylthiazole derivatives containing urea/thiourea groups. All the investigated compounds exhibited inhibitory activity on both hCA I and hCA II, with 1-(3-chlorophenyl)-3-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)urea being the strongest inhibitor. Structure-activity relationship study showed that most of urea derivatives were more inhibiting for hCA I and hCA II than thiourea derivatives. The electron-withdrawing groups at the phenyl ring increased the inhibitory activity compared to electron-donating groups.enArticleWOS:0003851487000078498869854610.1134/s1068162016050046