OZGURHAN, GDEMIR, ADUzuner, SELÇUKNURSOY, MUSTAFA ATİLLAVEHAPOGLU, ATURKMEN, SKACAN, A2019-10-052019-10-052014-01-01VEHAPOGLU A., OZGURHAN G., DEMIR A., Uzuner S., NURSOY M. A. , TURKMEN S., KACAN A., -Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.-, Anemia, cilt.2014, ss.576738, 2014https://hdl.handle.net/20.500.12645/8954Background. The two most frequent types of microcytic anemia are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and 𝛽-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting 𝛽-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.The Mentzer index provided the highest reliabilities for differentiating 𝛽-TT from IDA.eninfo:eu-repo/semantics/openAccessArticle24818016