GOKCEN, TanerGÜLÇİN, İlhamiOZTURK, TuranGoren, AHMET CEYHAN2020-10-292020-10-292016-12-01GOKCEN T., GÜLÇİN İ., OZTURK T., Goren A. C. , -A class of sulfonamides as carbonic anhydrase I and II inhibitors-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, ss.180-188, 2016http://hdl.handle.net/20.500.12645/26334Four groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO3-) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62-136.54 and 5.74-210.58nM, respectively.ArticleWOS:0003904108000218497639488010.1080/14756366.2016.1198900