Su, OzlemBEHALI, Anil GulselDEMIR, Aysegul DoganOZKAYA, Dilek BiyikUzuner, SELÇUKDizman, DİDEMOnsun, NAHİDE2019-10-052019-10-052017-01-01Su O., BEHALI A. G. , DEMIR A. D. , OZKAYA D. B. , Uzuner S., Dizman D., Onsun N., -The relationship between severity of disease and vitamin D levels in children with atopic dermatitis-, POSTEPY DERMATOLOGII I ALERGOLOGII, cilt.34, ss.224-227, 2017https://hdl.handle.net/20.500.12645/4865Introduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin. Aim: To assess the serum level of vitamin D in children with AD and determine its relation to AD severity. Material and methods: Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. The control group consisted of 37 healthy subjects. Results: The mean serum concentration of 25(OH)D3 in patients with AD was not statistically different from control subjects (p = 0.065). The vitamin D level was significantly lower in moderate and severe AD compared with mild AD, and this difference was statistically significant (p = 0.001 and p = 0.004). Vitamin D showed a negative correlation with serum total IgE levels (p = 0.007). There was no significant correlation between total IgE levels and SCORAD scores (p = 0.089). Conclusions: This study suggests that a low serum vitamin D level is inversely associated with severity of AD in children. Vitamin D has not been included in the routine treatment of AD because of the conflicting results of various studies. Thus, there is a need for more detailed and prospective studies.eninfo:eu-repo/semantics/openAccessArticleWOS:0004033867000068502000728810.5114/pdia.2017.6605428670250