Ozkaya, EMİNNURSOY, Mustafa A.Uzuner, SELÇUKErenberk, UFUKCakir, ERKAN2019-10-052019-10-052012-01-01Ozkaya E., NURSOY M. A. , Uzuner S., Erenberk U., Cakir E., -Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate-, HORMONE RESEARCH IN PAEDIATRICS, cilt.77, ss.351-357, 2012https://hdl.handle.net/20.500.12645/2214https://www.karger.com/Article/FullText/338785Aims: The objective of this study is to determine the effects of the long-term treatment with inhaled fluticasone propionate on osteocalcin, cortisol levels, and bone mineral status in children with asthma. Methods: This cross-sectional study examined 230 prepubertal children with asthma (aged 6–11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 μg (range: 200-350 μg). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were obtained from each participant. The control group consisted of gender- and age-matched children (n = 170) who were newly diagnosed with asthma and who were not being treated with corticosteroid. Results: The average age (± SEM) was 8.9 ± 0.7 years, their mean (± SEM) daily steroid dose was 180.3 ± 55.0 μg, with 236.5 ± 17.2 g total steroid use during treatment. Between the study and the control groups, no significant differences were observed in cortisol, osteocalcin levels, and BMD (p > 0.05). Conclusion: Long-term treatment with inhaled fluticasone propionate (100 μg twice daily) revealed no negative effects on serum osteocalcin, cortisol levels, and BMD in children with asthma.eninfo:eu-repo/semantics/openAccessAsthmaArticleWOS:0003069492000028486433473310.1159/00033878522760032