Kara, Sinem SipahiogluAtes, Mustafa YasinDeveci, GozdeCetinkaya, AhmetKahveci, Muhammet Übeydullah2020-10-292020-10-292019-03-15Kara S. S. , Ates M. Y. , Deveci G., Cetinkaya A., Kahveci M. Ü. , -Direct synthesis of tetrazine functionalities on polymer backbones-, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, cilt.57, ss.673-680, 2019http://hdl.handle.net/20.500.12645/25145Tetrazine mediated inverse Electron Demand Diels-Alder Reaction (IEDDA) is an important modification technique due to its high selectivity and super-fast kinetics. Incorporation of tetrazine moieties on polymer chains requires multistep synthetic pathways and a post-polymerization step leading to functional polymeric materials. Such approaches involve separate syntheses of polymer and the molecule which will be employed in modification. Herein, we introduce a straightforward synthetic approach for direct synthesis of tetrazine groups on polymers as side chains. As model systems, tetrazine functional poly(N-isopropylacrylamide)-and poly(ethylene glycol)-based polymers from corresponding precursor polymers with nitrile moieties as pendant groups are prepared and IEDDA Click Reaction is achieved with trans-cyclooctene derivatives. The click reaction is monitored by both NMR and UV-vis spectroscopies. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 673-680ArticleWOS:0004582699000028505894118310.1002/pola.29308