Cemil, BCYilmazer, DAtas, HCengiz, Fatma PelinCanpolat, FAlper, MGonul, M2020-01-202020-01-202017-08-01Cemil B., Yilmazer D., Atas H., Cengiz F. P. , Canpolat F., Alper M., Gonul M., -Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?-, Postepy dermatologii i alergologii, cilt.34, ss.322-327, 2017https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13446Introduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. Material and methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.info:eu-repo/semantics/openAccessArticleWOS:0004082544000068502664498810.5114/ada.2017.6931128951706