Karaman, Ecem FatmaÇELİK, BURAKOzdemir, SametTekkeli, Evrim KepekciDemirkoz, Asli BarlaGonullu, UmitUner, Melike2020-10-222020-10-222020-07-01Karaman E. F. , ÇELİK B., Ozdemir S., Tekkeli E. K. , Demirkoz A. B. , Gonullu U., Uner M., -INFLUENCE OF VEHICLES AND PENETRATION ENHANCERS ON ANTI-INFLAMMATORY EFFECT OF 18-beta GLYCYRRHETINIC ACID: KINETIC MODELLING OF DRUG RELEASE, IN VIVO AND EX VIVO EXPERIMENTS-, FARMACIA, cilt.68, ss.646-655, 2020http://hdl.handle.net/20.500.12645/24542Topical formulations of 18-beta glycyrrhetinic acid (18-beta GA) were designed for use in relieving inflammatory and painful conditions of the skin. Formulations were containing penetration enhancers that differ in penetration enhancing mechanisms. Anti-inflammatory effects of formulations and effects of penetration enhancers on penetration and permeation of the drug through rat skin were investigated. The total amount of 18-beta GA permeated from the base oil/water emulsion (53.19 +/- 22.25 mcg/cm(2) ) was approximately twice higher than the base oleaginous cream (29.17 +/- 3.85 mcg/cm(2)) while there was no 18-beta GA permeation from the base hydrogel formulation to the skin (p < 0.05). Incorporation of propylene glycol was generally found to increase 18-beta GA permeation to the skin. The highest oedema inhibiting activity was achieved in the oil/water emulsion containing propylene glycol followed by the base oil/water emulsion without a penetration enhancer (p < 0.05). This result was consistent with the ex vivo study. Limonene and oleic acid were found to be insufficient in 18-beta GA permeation to the skin.ArticleWOS:0005577869000108508911970010.31925/farmacia.2020.4.9