Gumus, ArzuKaradeniz, SerefUgras, Halil IbrahimBulut, MustafaCakir, UmitGoren, AHMET CEYHAN2020-10-292020-10-292010-09-01Gumus A., Karadeniz S., Ugras H. I. , Bulut M., Cakir U., Goren A. C. , -Synthesis, Complexation, and Biological Activity Studies of 4-Aminomethyl-7,8-dihydroxy Coumarines and Their Crown Ether Derivatives-, JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.47, ss.1127-1133, 2010http://hdl.handle.net/20.500.12645/25055The article focuses synthesis of novel 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca(2+), Mg(2+), Fe(2+), Zn(2+), Ni(2+), Cd(2+), Co(2+), and Mn(2+) ions at 25 degrees C +/- 0.1 with the 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma-Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity.ArticleWOS:0002824892000207795691246410.1002/jhet.435