Çarıkçı S.Kılıç T.Gören A. C.Dirmenci T.ALİM TORAMAN G. Ö.TOPÇU G.2023-12-202023-12-202023-01-01Çarıkçı S., Kılıç T., Gören A. C., Dirmenci T., ALİM TORAMAN G. Ö., TOPÇU G., "Chemical profile of the Anatolian Sideritis species with bioactivity studies", Pharmaceutical Biology, cilt.61, sa.1, ss.1484-1511, 20231388-0209https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85177695997&origin=inwardhttps://hdl.handle.net/20.500.12645/38850Context: The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia. Objective: In this review article, Sideritis species growing in Turkey have been evaluated for phytochemical constituents and biological activities. Methods: The data for the isolates, components and extracts of the Anatolian Sideritis species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022. Results: In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish Sideritis species were reported. Anatolian Sideritis species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. Sideritis plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC–MS studies. Most of the diterpenoids of Turkish Sideritis species have ent-kaurene skeleton, among them linearol, siderol, 7-epicandicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. Their cytotoxic, enzyme inhibitory, antinociceptive and antistress activities were less frequently studied. Conclusions: Sideritis species should be considered promising therapeutic agents in the treatment of upper respiratory tract and ulcer/inflammatory diseases.info:eu-repo/semantics/openAccessTıpEczacılıkTemel Eczacılık BilimleriYaşam BilimleriBiyoteknolojiMoleküler Biyoloji ve GenetikSitogenetikSağlık BilimleriTemel BilimlerMedicinePharmacology and TherapeuticsBasic Pharmaceutics SciencesLife SciencesBiotechnologyMolecular Biology and GeneticsCytogeneticHealth SciencesNatural SciencesKlinik Tıp (MED)Yaşam Bilimleri (LIFE)Klinik TıpFarmakoloji ve ToksikolojiMikrobiyolojiTROPİKAL TIPENTEGRE VE TAMAMLAYICI TIPFARMAKOLOJİ VE ECZACILIKBİYOKİMYA VE MOLEKÜLER BİYOLOJİBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİClinical Medicine (MED)Life Sciences (LIFE)CLINICAL MEDICINEPHARMACOLOGY & TOXICOLOGYMOLECULAR BIOLOGY & GENETICSMICROBIOLOGYTROPICAL MEDICINEINTEGRATIVE & COMPLEMENTARY MEDICINEPHARMACOLOGY & PHARMACYBIOCHEMISTRY & MOLECULAR BIOLOGYBIOTECHNOLOGY & APPLIED MICROBIOLOGYMoleküler TıpFarmakolojiFarmasötik bilimİlaç KeşfiTamamlayıcı ve Alternatif TıpMolecular MedicinePharmacologyPharmaceutical ScienceDrug DiscoveryComplementary and Alternative Medicinediterpenoidsessential oilsflavonoidsglycosidesiridoidsphenolicsSecondary metabolitesarticle8517769599710.1080/13880209.2023.22802533799088714841511611