Daskaya-Dikmen, CerenYucetepe, AysunKarbancioglu-Guler, FundaDaşkaya, HayrettinÖzçelik, Beraat2020-10-222020-10-222017-04-01Daskaya-Dikmen C., Yucetepe A., Karbancioglu-Guler F., Daşkaya H., Özçelik B., -Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants-, NUTRIENTS, cilt.9, 2017http://hdl.handle.net/20.500.12645/23547https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409655/Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.info:eu-repo/semantics/openAccessAngiotensin-I-converting enzyme inhibitory activityBioactive peptidesBioavailabilityDiabetesEnzymatic hydrolysisObesityPlant proteinsArticleWOS:0004013556000018501614483710.3390/nu904031628333109