Kilic, UlkanKILIÇ, ERTUĞRULTUZCU, ZEYNEPTUZCU, MEHMETÖZERCAN, İBRAHİM HANİFİYILMAZ, ÖKKEŞŞAHİN, FİKRETTİNŞAHİN, KAZİM2020-10-222020-10-222013-01-01Kilic U., KILIÇ E., TUZCU Z., TUZCU M., ÖZERCAN İ. H. , YILMAZ Ö., ŞAHİN F., ŞAHİN K., -Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway-, NUTRITION & METABOLISM, cilt.10, 2013http://hdl.handle.net/20.500.12645/24744https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-10-7Background: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effects such as nephrotoxicity and ototoxicity. Cisplatin chemotherapy induces a reduction in the antioxidant status, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drugs. Cisplatin-induced oxidative stress in the kidney was partially prevented by antioxidant treatments using superoxide dismutase, glutathione, selenium and flavonoids. Melatonin and its metabolites possess free-radical scavenging activity and it has been shown that they protect against cisplatin toxicity. However, the mechanism of the protective effects of melatonin against cisplatin-induced nephrotoxicity is still essentially unknown. We therefore designed this study to investigate the underlying mechanism of the protective effect of melatonin against cisplatin-induced renal damage in a rat nephrotoxicity model in vivo.NephrotoxicityArticleWOS:0003145416000018487213633710.1186/1743-7075-10-723311701