Hasan, AdriaHaque, EjazulHameed, RohilMaier, Paul N.Irfan, SafiaKamil, MohdNazir, AamirMir, Snober S.2020-10-222020-10-222020-09-01Hasan A., Haque E., Hameed R., Maier P. N. , Irfan S., Kamil M., Nazir A., Mir S. S. , -Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy-, LIFE SCIENCES, cilt.256, 2020http://hdl.handle.net/20.500.12645/24176Aims: Hsp90 is regarded as an important therapeutic target in cancer treatment. Client proteins of Hsp90 like Beclin-1, PI3K, and AKT, are associated with tumor development, poor prognosis, and resistance to cancer therapies. This study aims to analyze the role of Gedunin, an Hsp-90 inhibitor, in mediation of crosstalk between apoptosis and autophagy by targeting Beclin-1:Bc1-2 interaction, and ER stress.ArticleWOS:0005607685000068508692345410.1016/j.lfs.2020.11800032585246