ERKOÇ, RÇıKRıKÇıOĞLU, MAAINTAB, ETOPRAK, ALİKILIC, UGOK, OCETIN, AIZORLU, MEHMETKıSKAÇ, MUHARREMCAKIRCA, MUSTAFAKaratoprak, CUMALİERKAL, SNISEN, HC2019-10-052019-10-052015-06-01ERKOÇ R., ÇıKRıKÇıOĞLU M., AINTAB E., TOPRAK A., KILIC U., GOK O., CETIN A., ZORLU M., KıSKAÇ M., CAKIRCA M., et al., -GAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.-, Renal failure, cilt.37, ss.866-70, 2015https://hdl.handle.net/20.500.12645/2268https://www.tandfonline.com/loi/irnf20Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834+7G>A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus. Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834+7G>A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy. Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834+7G>A polymorphism (p = 0.837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p = 0.010). Conclusion: In our study, GAS6 intron 8 c.834+7G>A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.eninfo:eu-repo/semantics/openAccessdiabetic nephropathyArticleWOS:0003613384000218494105407510.3109/0886022x.2015.103460625869052